Aa
Any data for sofosbuvir+interferon+ribavirin response rates on Geno 1?
is there any formal data about tx which FDA approved on dec 6th 2013 for genotype I (a or b).
and anyone knows IL28 B genotype is significiant in this tx?
and anyone knows IL28 B genotype is significiant in this tx?
Here is a list of sofosbuvir trials Read the description of each trial look for the ones that include sofosbuvir+interferon+ribavirin GT1 some may include other GTs but don't look at ones that are GT2/GT3 exclusive.
For the appropriate trials look at the slide show presentation for more details.
http://hepatitisc.uw.edu/page/treatment/drugs/sofosbuvir-drug
If you are still looking for more info Google search by the specific trial name.
I don't know about "is IL28 B genotype is significant in this tx". Other members may be better able to answer your question or provide direct links to more specific information regarding your question.
hepatitisc.uw.edu - Hepatitis C Online
Hepatitis C Online is a free educational, web-based service that functions as a comprehensive resource for diagnosing, monitoring and managing the Hepatitis C virus infection.
and hcvguidelines.org are two of my top go to sources as a starting point for information about HCV and treatment.
Best of luck for you getting the right treatment and achieving SVR
For the appropriate trials look at the slide show presentation for more details.
http://hepatitisc.uw.edu/page/treatment/drugs/sofosbuvir-drug
If you are still looking for more info Google search by the specific trial name.
I don't know about "is IL28 B genotype is significant in this tx". Other members may be better able to answer your question or provide direct links to more specific information regarding your question.
hepatitisc.uw.edu - Hepatitis C Online
Hepatitis C Online is a free educational, web-based service that functions as a comprehensive resource for diagnosing, monitoring and managing the Hepatitis C virus infection.
and hcvguidelines.org are two of my top go to sources as a starting point for information about HCV and treatment.
Best of luck for you getting the right treatment and achieving SVR
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http://www.drugs.com/pro/sovaldi.html#S12.3
In a single-group study of sofosbuvir combined with peginterferon–ribavirin, patients with predominantly genotype 1 or 4 HCV infection had a rate of sustained virologic response of 90% at 12 weeks. Neutrino study
Sovaldi + Peg-IFN alfa + RBV 12 weeks
N=327*
Genotype 1† 89% (261/292)
Genotype 1a 92% (206/225)
Genotype 1b 82% (54/66)
Genotype 4 96% (27/28)
Outcome for subjects without SVR
On-treatment virologic failure 0/327
Relapse‡ 9% (28/326)
Other§ 1% (4/327)
SVR rates were 98% (93/95) in subjects with baseline IL28B C/C allele and 87% (202/232) in subjects with baseline IL28B non-C/C alleles
Good luck to you.
Nan