Cell to Cell transfer of hec-c

[Upbeat]

I am really surprised that know one responed to my earlier post.  This research paper explains more about why some people handle the virus and others don't and most important why viral load means nothen. With cell to cell transfer there is no way that TX is going to work.  I suggest you all read this. It explains why the virus moves so slow in most and can replicate so fast in others. As I always thought and the numbers bear me out,  you are more likely to die with the virus than because of it.  Sure its causing damage slowly but for the most part if you don't have cell to cell transference your bodies own imune system will keep it at bay.  There is a lot we still don't know about this virus and it bothers me some to see the fear factor so high that some jump into treatment with the chance of doing more harm than good.  
                                                                                                                                        Ron

[Whrose]

clarification of above.

it is the proteins on the lipid envelope that attach to circulating lipids. as there are only 2 main envelope proteins on the hcv- E1 and E2. i wonder if both or one has this ability?

[Whrose]

as usual as i reread HR comments i find a new gems to explore

your question stimulated this re read. although your inquiry was about PPC in relationship to circulating lipids i found something more remakable from his explanation.

i would guess that PPC has no effect to increase the development of the secondary lipid envelope coat of hcv because 1- PCC composed primarily of polyunsaturated fats actually decrease plasma triglycerides and cholesterol. 2- the addition of polyunsaturated fats in circulating plasma would not have any effect in the ability of the lipid envelope layer of hcv binding to plasma circulating lipids.
will be nice if HR comes in to elaborate! would be nice to clarify if the virus binds circulating HDL's or LDL's in plasma?

but even more remarkable in his explanation was the statement that hcv envelope proteins  bind to circulating lipids thus giving it that soft coat that interferes with antibody attachment to the viral epitope. in effect preventing the ability of the antibody from processing the viral epitope and neutralizing it.

wow! i thought antibodies were ineffective because of the envelope proteins E1E2 especially E2(envelope proteins) are hypervariable thus preventing effective antibodies forming due to the constant development of variable epitopes. (the genetic drift causing mutation and development of quasi species cause the hypervariability that are capable of neutralizing antibodies).

i never considered that the lipid layer on the envelope would also prevent antibodies from forming a strong bond to the viral epitope!  wow wow. this is the firist time i considered this aspect.

also i never understood the lipid coat to be able to attach more lipids when circulating in plasma. i always thought the bi layer lipid coat was formed from intracellular lipids during the virion maturation inside the cell and by the process of exocytosis. interesting now to realize the viron has the ability to attach circulating lipids in its defense system.

now my coggs are spinning lol!
i came across an interesting article about an emerging science in viral immunotherapy whose focus is to develop agents that will remove the lipid viral coat (delipidation) thus increase viral antigen presentation and processing.  
site     http://sec.edgar-online.com/2006/03/15/0001047469-06-003438/section2.asp
would love HR to comment on delipidation as a prospect to aid the development of an effective vaccine.

also one of my fav sites on hcv viral biology is
www.natap-org/2001/jun/MoleBio.PDF
i have lots more of such if you are interested

another insight in to the way the virus evades the adaptive (humoral) branch of the immune system!
thanks merry....i enjoy your comments and posts! our understanding is alike a baby compared to HR but perhaps together we babies can reach better understandings of chronic hcv
hugs

[CockSparrow]

All I have to say about your rants is to repost why HepC is called the Dragon.
The liver is represented by a dragon and is said to store anger.

Certainly applies to you
Have a Nice Day
CS

[merryBe]

sorry this is going to take me a long time to read through,

but a dumb question, regarding thick protein shells you said

>>>>>>>>>>>>>>>The virus manages this extremely critical  “escape from neutralizing antibody” feature by having evolved such a surface coat of proteins that it has enough lipophilic amino acid residues placed at strategic points as to bind circulating lipids, that give it a secondary, soft coat, that prevents the antibodies to reach the epitopes and hence effective, strong binding.

ok so help me understand, if more lipid protects the HCV from the antibodies being reached by the eritopes, then why would adding PPC to the health.meds regime not aide the virus as well by giving it extra protection?

I may be misunderstanding something here, granted, but with my limited knowledge of your lingo, it's kinda hard to be sure if this new info does damage to the PPC equation.
thanks

[lanier]

In the big picutre HCV is not getting it's fair share of dollars.  the statement you qoute is out of context.  Mr liver and I have been debating this.  I never said there was NO research, but I can tell you in the past ten years there were more dollars that is what I am talking about spent of erectile dysfunction than HCV.  and since I have no penis I feel like I got the "shaft"  

I don't want to argue the point anymore you guys are sold that HCv is just the cats meow when it comes to research so dream on.

I did not mean to offend you, but if I did life goes on for us both it really is no big deal, this is a BLOG
I thought people were "allowed" to share there knowledge and not have to fight for a different idea?  I am not right about anything heck I am wrong all the time I am human, I don't want a blue ribbon.  I just know what I know from where I have been.

have a nice day go Packers and crown 24 king

Lanier

[moahunter]

"on just about as much as your ridiculous statement of hundreds of pharmacutical companies beating down the doors to research this virus".
I don't understand most of this thread, and probably be no better off if I did. But this comment is unfair. We are very very lucky to have a disease that is common. There is money in this disease, so there is research occuring. If we had some uncommon, as many people do, there is just often not the money to commercialize potential drugs.