treatment of hep c

[tehmina]

hi ,

can any body tell me that  treatment for hep c genotype one b  telaperavir arrived in market or not.if yes then from where i can get it and how much it is effective.
tehmina

[buggs1]

thnx for checking spec

[spectda]

from the vertex web site:

http://investors.vrtx.com/releasedetail.cfm?ReleaseID=580154

"The approval of INCIVEK was based on data from three Phase 3 studies, which showed that people who received INCIVEK combination treatment achieved significantly higher rates of sustained viral response (SVR, or viral cure) compared to those who received pegylated-interferon and ribavirin alone, regardless of their prior treatment experience:

  
People new to treatment:
79 percent vs. 46 percent

People who were treated previously but did not achieve a viral cure:
-- Relapsers:
86 percent vs. 22 percent
-- Partial responders:
59 percent vs. 15 percent
-- Null responders:
32 percent vs. 5 percent"

"Prior Relapsers: Defined as people whose hepatitis C virus was undetectable after a full course of previous treatment, but whose virus became detectable during the follow-up period;
Prior Partial Responders: Defined as people who achieved at least a 2 log10 reduction in hepatitis C virus at week 12, but whose hepatitis C virus never became undetectable by week 24 of a prior course of therapy; and
Prior Null Responders: Defined as people who achieved a less than 2 log10 reduction in hepatitis C virus at week 12 of a prior course of therapy."

[buggs1]

without referencing  relapsers around  60%  nonresponders around 40%  theres also null responders partial responders and breakthrough

[tehmina]

then what is the response for repeaters.like my mom took peg theapy before.

[buggs1]

boceprevir is in pharmacies now  telaprevir should be by the end of the month  they both have the same mechanism of action ( protease inhibitors ) and are comparable in efficacy

mimi that 70% is for first timers only  

[Resilient_Mimi]

I have read that the company "Vertex" will be giving FDA's decision of approval status is expected by May 23, 2011. I hear that this med in combination with the pegylated interferon and ribavirin could boost the sustained response rate above 70%..