Fulminant central nervous system demyelination associated with interferon- therapy and hepatitis C virus infection

[Myown]

I remember making a comment to someone on forum saying "isn't it odd that we seem to see so many people being dx with MS. I personally know several people. At that time, I said I wonder if this could somehow be related to HCV, since hardly any doctor checks people for HCV unless the patient themselves asks. Now here in this study it says that the person developed MS AFTER the interferon theraphy,,,but what IF the HCV did in fact cause the MS and the interferon only brought it out - as it seems to do with other diseases/autoimmune after tx. Notice it says "neuropathological confirmation of MS associated with IFN- therapy and HCV infection is lacking." I hope they start to research in this area soon. My brain scan did show change in white matter - now whether I had it before tx or after - I'll never know...BUT the only way doctors will know if the interferon is causing brain abnormalities (or if the abnormalities are there already from the HCV) is to INCLUDE a brain MRI as part of the HCV exam. Because really, we have a deadly disease that affects all of our organs and all we get for an exam prior to tx is a few pushes on our stomach and some blood tests - maybe an eye exam. Since we DO KNOW this disease affects our entire body/brain, there needs to be more tests prior and post tx - IMO.

I found this interesting and wanted to pass it on to those who may also find it interesting.


http://intl-msj.sagepub.com/cgi/content/abstract/13/9/1100

Hepatitis C virus (HCV) infection is common in the general population and may coincide with disease in the central and peripheral nervous system. Interferon- (IFN-) is used as treatment for HCV infection. The therapeutic benefit is assumed to result from activation of natural killer cells and CD8+ T cells. Despite its beneficial effects, it has been associated with a number of autoimmune disorders, such as chronic inflammatory demyelinating polyneuropathy and multiple sclerosis. Several clinical reports including magnetic resonance imaging exist, but neuropathological confirmation of MS associated with IFN- therapy and HCV infection is lacking. We report a case of a female patient with chronic HCV infection who developed `acute MS'-like demyelinating disease after IFN- administration, with extensive lesions throughout brain and thoracic spinal cord. The patient died after a disease duration of 6 months. Brain autopsy revealed Baló-like demyelinating plaques with positive HCV sequences within florid lesions. The development of fulminant demyelinating disease after administration of IFN- suggests that autoimmune mechanisms such as T cell mediated tissue damage might be initiated or aggravated by IFN- therapy. Additionally, the presence of HCV RNA within the demyelinated lesion indicates a possible role in triggering or propagating disease. Multiple Sclerosis 2007; 13: 1100—1106. http://msj.sagepub.com


Key Words: CD8+ T cells • concentric sclerosis (Baló) • hepatitis C virus • interferon- • multiple sclerosis (MS)

[cjacks]

Hi

I just posted here for the first time a couple of min. ago . Was checking out this forum a little more and there this was .   WOW. This was what I was asking about ...  I'm on my way out .. but will check in as soon as I get back .     Thanks

Jo

[Myown]

wow is right! I can't believe I posted this and here you are asking about it - I just saw your thread.

Maybe you can print out the study and bring it to your doctor.

Talk to ya later - gotta run.
MO

[mikesimon]

Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2a therapy for chronic hepatitis C virus infection.
Khiani V, Kelly T, Shibli A, Jensen D, Mohanty SR.

Department of Medicine, Section of Gastroenterology, Center for Liver Diseases, The University of Chicago, 5841 S. Maryland Avenue, MC 7120, Chicago, IL 60637-1463, United States. ***@****.

The combination of pegylated interferon (Peg-IFN) and ribavirin is the standard of care for chronic hepatitis C virus (HCV) infection treatment. In general, common side effects related to this combination therapy are mild and are very well tolerated. However, peripheral neuropathy including demyelinating polyneuropathy related to Peg-IFN is extremely rare. We present the first case of an acute inflammatory demyelinating polyneuropathy (AIDP) associated with Peg-IFN-alpha 2a (Pegasys) after 16 wk of a combination therapy with Pegasys and ribavirin in a 65-year-old woman with chronic HCV infection. She developed tingling, numbness, and weakness of her upper and lower extremities and was hospitalized for acute neurological deficits. Her clinical course, neurological findings, an electromyogram (EMG), nerve conductions studies (NCS), muscle biopsy, and a sural nerve biopsy were all consistent with AIDP likely related to Pegasys use. The patient recovered completely with the use of intravenous immunoglobulin (IVIG) including physical therapy and neurological rehabilitation. It is very important that gastroenterologists and/or hepatologists recognize this rare neurological complication related to Peg-IFN treatment very early, since it requires a prompt discontinuation of therapy including an immediate referral to a neurologist for the confirmation of diagnosis, management, and the prevention of long-term neurological deficits.

PMID: 18186575 [PubMed - in process]

[Myown]

neuropathy and all that we have heard, but what struck me was the possible MS connection and I say this only because I have been seeing so many people dx over the last few years AND just wondering IF they have an underlying Hep c infection that the doctors aren't aware of because  they never check anyone for hep c it seems - unless you're toothless and and IV user -sad but true.

[mikesimon]

There seems to be a connection between the two diseases.

"Chronic inflammatory demyelinating polyneuropathy (CIDP)
As in Multiple Sclerosis, a similar demylenating condition, it is not possible to predict with certainty how CIDP is going to affect an individual in the future. The pattern of relapses and remissions varies greatly with each patient. A period of relapse can be very disturbing, but many patients make significant recoveries."
http://en.wikipedia.org/wiki/Chronic_inflammatory_demyelinating_polyneuropathy

Multiple sclerosis: Reports describe CNS white matter changes in patients with CIDP. Whether a true association exists between CIDP and multiple sclerosis remains unclear.
http://www.emedicine.com/neuro/topic467.htm

[Myown]

what I find interesting in what you posted is that the person got PN AFTER the 16 weeks tx - yet they say prompt discontinuation of theraphy if a person has certain symptoms - well she was already done. Just like me - all that tingles with my lips, tongue hands didn't start until AFTER tx at time of relapse - so I really wonder if they can recognize whats what. There are so many things that have similiar symptoms with diseases - that I feel like the doctors guess as much as I do And I am a big "guesser," at symptoms, as you know:)

[cjacks]

MO,

Thanks ,    You're right, giving this to my dr. might be helpful , He needs help figuring this all out . I just printed it and will give it to all my docs..

On the MS forum it is said that  a cold or flu or stress can bring on an episode /exacerbation .  So it would make sense that hep c could do the same. Or the stress from the interferon tx.  or ???

The treatment for MS is interferon .... YIKES !!   There is one that is not . ??  I don't know if I want to put another drug in my body.    There's much to think about.

I still don't have an answer to the question , does interferon cause mitochondrial DNA damage??  anyone have a guess??

Jo

[Bobby1952]

The treatment for MS is interferon .... YIKES !!  

Are you telling me that Interferon is suspected of causing or bringing on a episode of MS and the tx is Interferon?? How could this be? Did I understand this correctly.

Bobby

[cjacks]

Bobby;

I don't know if interferon has anything to do with MS . We were discussing the article above . Its interesting and compelling.

I had hep  c   was tx.d with two courses of interferon's.  During tx. I did have some neuro problems..  Now seven yrs later am sick again ( 4yrs.) probably MS , so I am asking questions.

Jo

[sldb]

I have a friend who is taking interferon injections for MS.

[Myown]

Its very confusing - here it says it can cause MS, yet people do take interferon shots for MS treatment.

I still wonder though if the virus itself can cause MS?

" Additionally, the presence of HCV RNA within the demyelinated lesion indicates a possible role in triggering or propagating disease."

[Myown]

http://www.mult-sclerosis.org/demyelination.html

So this looks like it can all tie into the title of the thread.....

"Demyelination is the major underlying factor responsible for the symptoms of multiple sclerosis (MS). Demyelination is the destructive removal of myelin, an insulating and protective fatty protein which sheaths nerve cells (neurons). More specifically, the myelin is wrapped around the long extensions of neurons called axons. During MS relapses, patches of white matter in the central nervous system that normally contain tracts of myelinated neurons become inflamed and lose their myelin. These patches of demyelination are known as lesions.

The cause and precise mechanism of demyelination is not clearly understood but there is good evidence that the body's own immune system is at least partially responsible. Acquired immune system cells called T-cells are known to be present at the site of lesions. Other immune system cells called macrophages (and possibly mast cells as well) also contribute to the damage.

Myelin is produced by special "glial cells" in the central nervous system called oligodendrocytes. Oligodendrocytes and axons have a many to many relationship - that is one oligodendrocyte produces myelin for several axons and one axon has several oligodendrocytes producing its myelin. In MS, it is not just the myelin that is destroyed but also these oligodendrocytes and occasionally even the axons themselves.

Axons use an electrochemical mechanism to transmit nerve impulses - the action potential. This requires sodium and potassium ions to pass through a semi-permeable membrane around the nerve. It is believed that the myelin not only insulates and encases this electrochemical process but also actively assists it. When axons become demyelinated, they transmit the nerve impulses 10 times slower than normal myelinated ones.

During periods of MS remission, the oligodendrocytes repair the damaged axons in a process called remyelination. However, very often the oligodendrocytes are also destroyed which delays or prevents remyelination from happening. Additionally, another kind of glial cell, called astrocytes, cause scar tissue to form in place of the myelin. Scar tissue does not perform the same function as the myelin. As the disease reaches its more advanced phases, the axons themselves are often destroyed as well."

Demyelination links:
Multiple Sclerosis:

[Myown]

I would say IMO IF interferon injections can cause MS,,,THEN so can an overly-stimulated immune system (without any artificial interferon) cause the body is ramped up - pumped up trying to get rid of a virus (hepc in this case I am talking about, but IMO doesn't necessarily have to be that specific virus) so with all this interferon being charged up - this could possibly cause this demyelination,,,,but as I stated before,,UNLESS the doctor gives brain MRI's PRIOR to hep c treatment, we will never know if the 'change in white matter' was PRIOR to tx (from our bodies own interferon possibly) OR was it from the tx itself ?

[cjacks]

OMG..     Thanks so much for all the info .  I have many questions for the docs. These sites will certainly  give them something to think about .  

I have major cog fog at the moment , I feel my responses to you are woefully inadequate . I do send my sincerest thanks and hope to get some brain power back so I can discuss this in greater depth with you or anyone who is interested .  

I would love to find more individuals who are having this experience .  I've tried going through the search , but didn't find much . I'm running out of steam already . I'll try more later

Jo

[Myown]

I have major cog fog at the moment , I feel my responses to you are woefully inadequate . I do send my sincerest thanks and hope to get some brain power back so I can discuss this in greater depth with you or anyone who is interested .
---------------------------------------------------------------------------------------------------------------------
Your welcome.
You're doing fine. There are big brains on this forum and I am not one of them. We all try to provide information for one another to bring to our doctors. Always feel free to post and ask questions. Someone will always try to help.

Keep in touch with us all. I will most likely be going underground (only private messaging) once I start treatment and just come on when I need to ask questions,,,(and you can private message me whenever you like also.)

Good luck!

[DoubleDose]

I think that it may boil down to a situation where either and both of the above may be responsible for creating these problems and diseases.  I think we have seen evidence that HCV alone can and does often cause a range of other serious diseases, in some people, aside from liver disease.  We also see clear evidence that the interferon can at times generate very serious syndromes, or actual disease processes on its own, and not only within previously HCV infected patients.  The last part of the equation is that HCV may also create the underlying mechanisms for various diseases to manifest, but it may be a long slow process.  The interferon, combined with the underlying HCV processes at work, may both together push serious diseases or syndromes into active mode in some people.  Ultimately there may never be a clear 'either/ or' answer to what is the real cause, because it may be that both the interferon and the HCV  act synergistically in many cases to cause these problems.  It could range from being totally due to the HCV in certain cases, to being any combination of the two, or at the other extreme, may be entirely due to reactions to the interferon, in others.

Now, the question of whether MS might be possibly caused by interferon, or HCV in some people seems to me to be very likely, and I would think that maybe this is because the interferon and the HCV really provoke similar responses by the body.  Maybe the HCV just does it in a less intense way, over longer, more gradual periods of time.  Probably in both cases we are looking at fallout and illnesses generated by immune system responses, and internal self-attack within various systems.   Maybe some people develop diabetes, or thyroid disease, and others develop EMC, vascular disease, or MS, Lupus, etc.  Most of it would be generated in similar ways, whether by the HCV or the Interferon.  That's my take on it anyway.

DoubleDose

[Myown]

Yup,I was hoping you saw this thread. I was going to PM you if you didn't. But it really hit me cause I think it was to you that I had just recently said - maybe in one of the "occult" threads - that doesn't it seem odd we are seeing so many people getting MS.

Now whether its the bodies own interferon in high gear trying to rid the HCV virus or maybe some other virus,,,but to me it seems plain as day that since the "artificial interferon" can cause MS - so would someones own interferon if over stimulated cause it.

But I do think everyone with MS should be tested for HCV and if neg, they should be checked for other viruses or anything that would cause their body to produce excess amounts of interferon.

Just as it seems that those that know they had hep c for many years,as non A non B, many times these people will have autoimune diseases - psoriasis etc.

And many of us have borderline ANA. I remember you said you do and so do I. Now if pushed over the border - who knows what will manifest. This I believe is why so many people come out ot tx with post tx sx......before tx their own interferon was in high gear causing borderline- but unable to identify - autoimmune diseases,,,but then add mucho interferon once tx starts and it pushes you over the hill into more symptoms of the underlying autoimmune disease or some even get full blown autoimmune disease.

[alagirl]

I was previously well prior to gettiing hcv, except for the anemia, which was under control.  The day I began treatment, before I took my first shot, my doc did think to send me for an entire MRI series.  Now I had only had hepc for three months, but that MRI - which I just got my hands on - is horrible.  I'm pretty scared about it.  I'm going to go talk to my hematologist, since he happens to be an oncologist.  

Prior to this, all of my MRI's have been normal save for three small benign tumors in my liver.  Now I have a huge tumor on my ovary, a swollen inguinal lymph node, and this huge portion of bilateral gluteal fat stranding, more prominent on the left side.  the left side of my lower lung is scarred (I've NEVER had a serious cold or illness involving the lung), and I now have a splenule (that's new too).  I'm going to have them run my entire body through the PET scan.  That fat stranding can happen adjacent to cancerous tumors, and it also can happen due to infection.  I'm going to go pick up my other MRI's from Birmingham and see what the hell is going on.  Surely to God this couldn't be from just my three months of hepc, even though I got so sick from it?

[beamishboy]

excellent,enlightening & disturbing thread.  

[Myown]

Alot of times these scans can freak us out until the doctor reads them and shrugs and says "that's nothing."  That happened to me when I saw "reactive Lymph nodes" on mine and the doctor in Boston said don't worry about it. I hope he's right though :)
But I guess I did stop worrying about it cause I forgot about it until I just mentioned it to you. Now because I reminded myself, I will think about my "reactive lymph nodes" the rest of the day. lol

[njrpo842]

I hope you are doing well.
I am new at the forum and been reading your postings, it kind of freak me out a little since I was diagnosed with HVC and told by my Dr. to start treatment as soon as possible. He refered me to Duke( since I live in N.C.) I am 65 years old, diabetic and hypertensive, to top it off I smoke and very nervous person, I am very afraid of the so called side effects and what I have read here today, I am seriously considering to try some herbal or holistic remedies and pray for the best, I have heard a lot about Maximum Milk Thistle. What do you think?  Will appreciate your coment.

[merryBe]

more I read the more apparent mandatory testing should be.
yes, a whole body MRI and IFG-1 should be standard before tx if HCV is found, not just a biopsy.

we call the other disease like this ne "Accquired immune deficiency syndrome (AIDS) for a reason.

the reason is equally valid for HCV.
It is actually a disservice to call it this. It is a virus that breaks down multiple systems, as does the tx.
It effects the immune system respnses and can therefore manifest as myriad other disease. Once we dicover the root disease, we may be able to halt the progression of the other damages being done, but this will depend upon whether we get good diagnosis and tx of our immune systems and endocrine systems as well both prior and post HCV tx.  That includes making sure the tx does not permanently comprmises our  lymph or endocrine systems. there  are ways t halt and reverse demylination caught in time....much of this is dependant on restoring underlying health and or eradiacation of what has begun the cycle of degeneration.

[cjacks]

njrpo842,

I'm sorry you've gotten this dx.  I can't tell you whether or not to treat.   When I got sick , I was very disabled.  For the first two yrs. I was in bed, only getting up for the bathroom or dr. I slowly got to were I could move around , in the house a little .

So when a dx. was made in 90  of course I was thrilled with any tx. I was young-ish ( forty) and very ill.   Didn't know I should weigh anything . I only wanted to be better and this is what dr. said to,( Columbia Presbyterian, N.Y.)  The first tx. was interferon, without success.

  It took nine more yrs of not being well to find ITF/ Reba combo .  I was forty -nine and wanted to try to have some kind of life( Which had been on hold since I was thirty six). So I did tx again . ( with all the side effects - there are meds now for side efects , In the olden days   :)     we were not offered anything other than OTC , I had no idea I could ASK for them,  sooo naive)  

I would do it again , even knowing that I may develope MS down the road , ( the MS may have been there anyway )   I needed to try ...    

Now finally getting to my point..  I don't know your history    but if I were sixty-five and not feeling too bad, I'd go the herbal route .  Go to Duke and tell the docs your concerns , I think the medical profession is coming around to the possibility of a more conservative approach to tx.  and holistics.     PLEASE stop smoking  , that would so improve your health greatly

I hope I helped ..  I did not mean to scare any one away from tx.   I get result back from LP soon , will have more answers for myself .If you want to PM that would be fine , love to hear what's up

MO    Thank you so much for making me feel comfortable here ..  I would absoluely love to be in touch while you do your tx  .

Take care           Jo

[Myown]

just read something and I wanted to pop this back up to the top for that reason