Addtional New Data on SSRI evaluations:
: J Clin Psychiatry. 2004 Aug;65(8):1064-1068. Related Articles, Links
"Dopamine-Dependent" Side Effects of Selective Serotonin Reuptake Inhibitors: A Clinical Review.
Damsa C, Bumb A, Bianchi-Demicheli F, Vidailhet P, Sterck R, Andreoli A, Beyenburg S.
Department of Psychiatry, University of Geneva, Geneva, Switzerland (Drs. Damsa, Bianchi-Demicheli, and Andreoli); the Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg (Drs. Bumb and Beyenburg); the Federation des Services de Psychiatrie d'Adultes, Hopital Civil 1, Strasbourg Cedex, France (Dr. Vidailhet); and the Department of Psychiatry, Jolimont Hospital, La Louviere, Belgium (Dr. Sterck).
OBJECTIVE: Neurophysiologic findings indicate an inhibition of dopaminergic neurotransmission by selective serotonin reuptake inhibitors (SSRIs). This article highlights the relationships between changes in dopaminergic neurotrans-mission induced by SSRIs and the occurrence of certain side effects such as hyperprolactinemia, extrapyramidal symptoms, sexual and cognitive dysfunction, galactorrhea, mammary hypertrophy, and, more rarely, gynecomastia. DATA SOURCES AND SELECTION: A systematic search of the literature in English, French, and German from 1980 to 2004 was performed in MEDLINE, EMBASE, and the Cochrane Library using the keywords SSRI, dopamine, serotonin, side effects, antidepressants, citalopram, escitalopram, sertraline, paroxetine, fluoxetine, fluvoxamine, and nefazodone. References cited in all trials were searched iteratively to identify missing studies. All studies concerning inhibition of dopaminergic neurotransmission by SSRIs and SSRI-related side effects were considered. We retained 62 significant articles debating the subject. DATA EXTRACTION AND SYNTHESIS: We critically reviewed the studies, depending on the methodologies (case reports, clinical reports, randomized studies), and assessed the pertinence of "dopamine-dependent" SSRI-related side effects. The analytic review of these articles suggests that some specific SSRI-related side effects be classified as dopamine-dependent. CONCLUSIONS: At a clinical level, it could be useful to underline dopamine-dependent characteristics of some SSRI-related side effects. This approach would allow clinicians the opportunity to search other dopamine-dependent side effects systematically. At a pharmacologic level, this approach could stimulate the development of molecules with a "corrective" function on dopamine-dependent side effects of SSRIs by facilitating dopaminergic neurotransmission.
PMID: 15323590 [PubMed - as supplied by publisher]
Hello,
The following items have been recently posted to www.hcvadvocate.org
September 2004 HCV Advocate newsletter - This month
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15332269">Role of beauty treatment in the spread of parenterally transmitted hepatitis viruses in Italy</a>
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15330905">Interferon Alpha-2b and Ribavirin for Patients with Chronic Hepatitis C and Normal ALT</a>
<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15330906">Chronic Hepatitis C and Normal ALT: Considerations for Treatment</a>
<a href="http://www.natap.org/2004/HCV/090204_01.htm">Can You Have Multiple Genotypes?</a>
TnHepGuy
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15332269
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15330905
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15330906
http://www.natap.org/2004/HCV/090204_01.htm
<a href="http://janis7hepc.com/">The Janis Web Site.</a>
<a href="http://www.hepcsurvivalguide.org/comboguide.htm">The A-Z Combo Survival Guide.</a>
<a href="http://www.hepatitisneighborhood.com/">The Hepatitis neighorhood- worth the time to register.</a>
<a href="http://www.omega3profile.com/services_testsexplained.htm">Blood Tests results explained.</a>
Just a few good links to some very good information.
TonyZ
Jumping to the front of the line for an organ transplant is unfair.
By Arthur Caplan, Sheldon Zink and Stacey Wertlieb. Arthur Caplan is director of the Center for Bioethics at the University of Pennsylvania. Sheldon Zink is a senior fellow and Stacey Wertlieb Published September 1, 2004
An article about organ donation and how those who can aford to mount a media campaign byebasses the system and the person closest to death may not get an organ they need in time.
http://www.chicagotribune.com/news/opinion/oped/chi-0409010047sep01,1,7634300.story?coll=chi-newsopinioncommentary-hed
Good haul of data this morning--thank you all. Regarding the "Dopamine-Dependent" Side Effects of Selective Serotonin Reuptake Inhibitors," this might suggest that anyone taking SSRI's while on teatment might also want to be supplementing with SAME-e, in order to maintain adequate dopamine levels.