HCV TREATMENT

[nina_9783]

which is better peginterferon alfa-2a or 2b?

[willbb]

Probably more important than changing the INF. type would be the addition of one of the new DAA's available(that is if you have Gen type 1)
If you have G 2 or 3  then  sometimes changing the type of INF. as well as possibly increasing Riba amt has been tried with some success..

There have been some trials that have experimented with  Inci and other DAA's on patients with Geno type 2 ..you may want to look into that or possibly waut until there are more efficacious treatments avail.

Hopefully your doctor has discussed this with you and let you now the options as a  prev. treated patient..

Best ..
Will

[nina_9783]

thanks for your reply
i havre HCV, and i'd been treated with pegasys (alfa 2a) but it failed, so my doctor will start treating me with pegintron 150mcg (alfa 2b)

[Sentinel13]

I've taken both 2a & 2b. For me, 2a had less side effects. I've been told that 2a has a smaller peg than 2b and that's why it has less side effects. I'm not a chemist so I can't confirm that information. Just know that 2a was better for me. Best, Sentinel

[willbb]

Do you have HCV?

While they have slightly different mechanisms of action ,there are conflicting reports which one may be better
Most knowledgeable doctors treating HCV concur that overall there is very little difference in the rates of success.
Will

http://www.hepatitis-central.com/mt/archives/2008/08/hep_c_treatment.html

While logic might lead one to assume that a dosage customized for each individual would deliver safer and more effective results, the data does not completely support this view. The conflicting evidence already in existence clearly indicates that more adequately funded, large, impartial, well-designed studies comparing the two pegylated interferons are needed. Since the differences between Pegasys and PegIntron appear to be negligible, those doing combination therapy for the first time have little reason to be concerned about which pegylated interferon their physician has prescribed.