WOW! Quite a ride you have had for a 41 yr old. Feels like I know more then I should about you :-) I did not read it all because I felt it was a little to personal for me to read with the woman stuff, etc. Anyway I hope HR sees it and is able to read it all. he is the guy that should be able to give you some answers. Hope you feel better soon.
You sweetie - you can read it -- I wouldn't have posted it otherwise.
I think in sharing - we all help each other become more aware of the hidden possibilities of problems, reactions and outcomes of medications, lack of medications and treatments...
In every action - there is a reaction.
Chaos theory 101. LOL!
I put it up to share - as well as to glean some serious information. I'm a mild case ---- People like DebNev and Alagirl --- wow - they make me look like a sissy. LOL! They're amazing people to have taken such a hard ride.
Meki
ok i have read it all and now know you even more :-)
Wanna get married? LMAO - I could always use a couple extra hubbys...
Thanks copyman - you're a doll.
Meki
Had a healthly life havent Ya.
Paying for all them teenage sins i bet -lol
Sheesh. I would have gone spare ages ago.
CS
Wow, you've been through the mill, girl! I'm sorry you're still suffering, 'cause this should not happen to nice people like you. Anyway, I think the referral to a rheumatologist is definitely in order, because they are the specialists who deal with AI issues.
Since joining this group, I've noticed scads of people who have various connective tissue or AI problems - before, during and/or after tx for hcv. I'm sure you've done your homework googling this, hence the inquiry to HR. But in the meantime, can't you appeal to your doctor's scientific curiosity? At one point in their lives, I figure, most of these doctors were good students or they wouldn't have been admitted to med school - and if you can pique their interest, you can sometimes get them off their fat ***** and into research mode.
Be well,
pigeon
"and if you can pique their interest, you can sometimes get them off their fat ***** and into research mode. "
OMG --- ROFLMAO! I just spit my Dr. Pepper onto the screen... LMAO!
That was precious.
Wow! I admire you for your strength and positivity after all you have been through and still are. I pray that your suffering will end very very soon.
I send you a little sun and warmth from Europe.
Marcia
There have been some articles suggesting that celiac disease can be triggered by interferon. This could cause IBS symptoms and joint problems too. All you'd have to do to test it would be to found out all the source's of gluten and avoid them for a couple weeks and see if there is an improvement. just and idea I had ...don't know if it's worth anything. One article lately stated that gluten sensitivity is very prevelant in people taking interferon and causes some of the symptoms they experience. Most people go back to normal but it remains afterwards in others. This might be something to check in to. I have also read that it is a very underdiagnosed problem.
I
Meki, I’m sorry that you have all of those problems. I also find it amazing that you are always so upbeat. This link touches on some of your questions:
http://www.hcvadvocate.org/hcsp/articles/Bonkovsky -2.html
Extrahepatic Manifestations of Chronic Hepatitis C
Roderick Remoroza, MD, and Herbert Bonkovsky, MD
(To see the figures and illustrations in this article, please download the pdf version.)
Although most patients with chronic hepatitis C are asymptomatic, an appreciable number will experience symptoms that are due to the liver disease and/or extrahepatic manifestations of HCV infection. Recognition of these symptoms will lead to early diagnosis and treatment of hepatitis C. Fatigue is the most common symptom of chronic hepatitis C and is most often mild. Intermittent right upper quadrant pain, anorexia and nausea occur less commonly.
Chronic hepatitis C infection predisposes patients to the development of diseases involving other organ systems including the kidneys, the skin, eyes, joints, immune system, and the nervous system. There are many extrahepatic manifestations of hepatitis C: some are relatively common (e.g., cryoglobulinemia), whereas others are infrequent and their association with hepatitis C has not been clearly defined. Only the common extrahepatic manifestations with clear association with hepatitis C will be discussed in this review.
CRYOGLOBULINEMIA
Cryoglobulins are antibody complexes that precipitate as serum is cooled and that dissolve on rewarming (1). These complexes contain hepatitis C virus (HCV) particles and can precipitate in the walls of small and medium sized vessels. There are three types (I, II, III) of cryoglobulinemia .Type II or “mixed” cryoglobulinemia (MC) is the one most commonly associated with chronic hepatitis C infection. This type is called “mixed” because the antibodies that are found are of two kinds. One antibody is a polyclonal (i.e., from more than one group of cells) antibody (IgG), and the other antibody is a monoclonal (IgM) directed against the IgG. The frequency with which cryoglobulins are detectable in serum of patients with CHC depends on how carefully samples are handled and upon the methods used for detection of cryoglobulins. Because these proteins precipitate from serum as it is cooled, the blood must be kept at body temperature after it has been obtained until it has clotted and the serum has been drawn off. Then the serum is tested for the abnormal proteins. If this precaution is not observed, the test may be spuriously negative.
The skin, kidney, nerves and joints can be affected by cryoglobulins. Cutaneous leukocytoclastic vasculitis is a skin lesion that appears as palpable purpura (hemorrhages in the skin that result in the appearance of purplish spots or patches) that usually affects the lower extremities over the shins (Fig 1). These lesions are caused by plugging of the dermal capillaries (very small blood vessels in the skin). Successful treatment of the hepatitis C infection with interferon (+ ribavirin) usually results in resolution of the skin lesions.
Cryoglobulins also affect the nervous system in some HCV infected patients. The most frequent symptoms and signs are those of chronic sensory polyneuropathy, although acute or subacute encephalopathy has been reported as well (2,3). “Restless leg syndrome” and Guillain-Barré syndrome have also been reported (4). The mechanism of nerve involvement is thought to be MC-well-established related vasculitis of the small blood vessels that supply the nerves. There is no well-established treatment. Treatment with interferon, corticosteroids, or cyclophosphamide (cytoxan) has not shown any consistent results although some patients appear to respond to one or a combination of these drugs (5).
KIDNEY MANIFESTATIONS
The kidneys are also affected in some patients with hepatitis C. The most common kidney disease related to hepatitis C infection is membranoproliferative glomerulonephritis (MPGN) (6). The prevalence of MPGN varies with geographical location. It is more common in Japan and is less frequently seen in France. Patients with MPGN usually complain of weakness, edema and have systemic arterial hypertension. Urine of such patients contains a lot of protein (>3.5 g/day), a condition called nephritic syndrome. Other abnormalities include low serum albumin (due to losses in the urine), decreased complement levels, and the presence of rheumatoid factor and cryoglobulins. MPGN may sometimes occur in the absence of cryoglobulinemia. Another kidney disease called membranous nephropathy (MN) is less common in HCV infected patients and is not associated with cryoglobulinemia or rheumatoid factor but is associated with heavy proteinuria (7). The mechanism of the disease is still unclear, but some studies suggest that it is caused by circulating complexes of antibodies and HCV particles directly causing damage to the kidneys as they are deposited in the glomerulus and tubules of the kidneys. Some authors recommend treatment of patients with HCV-related kidney disease even in the absence of active liver disease. The current treatment of choice for HCV infection is interferon and ribavirin. However, in patients with severe renal failure, only interferon monotherapy is recommended because ribavirin cannot be removed by dialysis. Thus, it accumulates and causes severe breakdown of red blood cells (hemolysis) and anemia.
SKIN LESIONS
Porphyria cutanea tarda (PCT) is the most common form of the porphyrias, a group of diseases characterized by defects in one or more of the enzymes involved in the production of heme. This results in the overproduction of porphyrins or its precursors. Patients with PCT often present with blisters and vesicles on the dorsal aspects of the hands, forearms, back of the neck and face. These lesions develop in areas that are exposed to the sun and that sustain minor trauma. Increased facial hair and pigmentation changes are also noted. In some patients, as the injury becomes chronic, scarring, alopecia and thickening of the skin may occur. The skin lesions may be further complicated by deposition of calcium and formation of non-healing ulcers. See Figure 2. Patients with PCT who are of northern European origin were also found to have increased prevalence of HFE gene mutation, the gene found to be responsible in most cases of hereditary hemochromatosis. In addition to iron, heavy alcohol use and use of estrogens are also major risk factors for the development of PCT. The treatment of PCT involves dietary restriction of foods rich in iron, and avoidance of alcohol and estrogen use. Phlebotomy to remove iron is the first treatment for most patients with PCT. In patients with PCT, we recommend iron depletion by phlebotomy before initiating antiviral therapy with interferon and ribavirin. Antimalarial drugs like chloroquine have been used in the treatment of PCT as well (8).
In a large case–control study of 34,204 veterans, lichen planus, vitiligo and PCT are the skin disorders that have been found to have significant association with HCV infection (9). Lichen planus is a disease of the skin and mucous membranes that appears as violaceous, scaling papules usually located on the limbs and white reticular lesions on the mucous membranes (See Fig 3). It is suggested that this is an autoimmune response to an antigen shared by HCV particles and the basal cell layer of the skin. Vitiligo is an acquired loss of pigmentation of the skin. The loss of pigmentation is usually found around body orifices like the mouth, eyes and nose and on the extensor surfaces of the elbows and knees as well as the wrists. Interferon has not been found to be uniformly effective in the treatment of lichen planus.
Part 2
RHEUMATOLOGIC and AUTOIMMUNE MANIFESTATIONS
Myalgia (muscle pains), fatigue and arthralgias (joint pains) are common manifestations of HCV infection. HCV-related arthritis commonly presents as symmetrical inflammatory arthritis involving small joints. The joints involved in HCV-related arthritis are similar to rheumatoid arthritis (RA). This sometimes makes it difficult to differentiate true RA from HCV patients with positive rheumatoid factor but without RA. HCV-related arthritis is usually non-deforming and there are no bony erosions in the joints. A marker called anti-keratin antibodies has been studied to differentiate true RA from HCV related arthritis. In a recent study, 71 patients who were rheumatoid factor positive were tested for anti-keratin antibodies. Anti-keratin antibodies were detected in 20/33 (60.6%) patients with true RA and only 2/25 (8%) patients with HCV-related arthritis (10). Patients with HCV-related arthritis seldom respond to anti-inflammatory medications, and although there are no controlled trials to address this issue, it has been recommended to treat these patients with combination antiviral therapy of interferon and ribavirin (11).
Sjogren’s syndrome (SS), an autoimmune disease characterized by dry eyes and dry mouth has been found in some studies to be more common in HCV infected patients. They differ from primary SS in that they do not have lung and kidney involvment. Thus it is recommended to test for HCV infection in patients with SS or primary SS. A study by El-Serag of 34,000 veterans failed to show a significant association between HCV infection and diabetes, SS, or autoimmune thyroid disease (9).
Interferon therapy of HCV infection may also trigger the development of autoimmune diseases, the most frequent of which is autoimmune thyroiditis (Hashimoto’s thyroiditis). This may lead transiently to hyperthyroidism, but eventually to hypothyroidism (underactive thyroid) and to the need for life-long thyroid replacement therapy (Bonkovsky & Mehta).
LYMPHOMA
B-cell non-Hodgkin’s lymphoma (NHL) has been linked to HCV infection. This is probably due to the long-standing stimulation of B cells caused by chronic HCV infection, although other factors must be important because most patients with CHC do not develop such lymphomas. A high prevalence of HCV was found in patients with immunocytomas, a low-grade type of lymphoma, which was associated with cryoglobulinemia. Another study linked HCV infection and splenic B-cell lymphomas. Seven of nine patients with splenic lymphoma were treated with interferon monotherapy. Two patients who had detectable HCV RNA after treatment received combination therapy of interferon and ribavirin. All nine patients had sustained virological responses and had remission of their lymphoma, as well. On the other hand, six control patients with splenic lymphoma without HCV infection did not respond to interferon treatment at all (12). It is therefore reasonable to screen for HCV infection in patients with splenic lymphoma as well as other low grade NHL.
EYE MANIFESTATIONS
HCV infection has been associated with several eye disorders. Keratoconjunctivitis sicca (dry eyes) is part of SS. Mooren’s ulcer is a rapidly progressive, painful ulceration of the cornea. The diagnosis is made by exclusion of other causes of corneal ulcer. A few cases of Mooren’s ulcer and HCV infection have been reported. In at least two of these patients, the ulcers did not respond to steroid and cyclosporine drops but did respond to interferon alfa-2b (13). Damage to the retina of the eye (retinopathy, which includes cotton-wool spot formation, hemorrhages and arteriolar occlusion) is a frequent complication of interferon therapy. Fortunately, the retinopathy is usually reversible once treatment is stopped and sometimes even improves despite continuation of therapy. However, patients receiving interferon who experience visual symptoms should hold treatment and undergo careful eye examinations by eye specialists.
SUMMARY
In summary, extrahepatic manifestations of chronic hepatitis C are varied and involve a number of organ systems. Physicians and patients should be aware of these signs and symptoms, and testing for HCV should be done in patients who manifest these. This may lead to early diagnosis and successful treatment of chronic hepatitis C infection.
REFERENCES:
1) Ferri C, Zignego AL, Pileri SA. Cryoglobulins. J Clin Pathol. 2002; 55:4-13.
2) Authier FJ, Pawlotsky JM, Viard JP, Guillevin L, Degos JD, Gherardi RK. High incidence of hepatitis C virus infection in patients with cryoglobulinemic neuropathy. Ann Neurol 1993;34:749–750 (Abstract).
3) D. H. McKee, A. C. Young, A. Alonso-Dominguez, J. I. Tembl, J. M. Ferrer, M. T. Sevilla, A. Lago, J. J. Vilchez, and F. Mayodomo Neurologic complications associated with hepatitis C virus infection Neurology2000; 55: 459 - 459.
4) Lacaille F, Zylberberg H, Hagege H,et al,. Hepatitis C associated with Guillain-Barre syndrome. Liver 1998 ;18:49(Abstract)
5) John M. Levey, Bjorn Bjornsson, Barbara Banner, Mary Kuhns, Rajwant Malhotra, Nancy Whitman, Paul L. Romain, Thomas G. Cropley, and Herbert L. Bonkovsky, Cryoglobulinemia in chronic hepatitis C infection: A clinico-pathological analysis of 10 cases and review of recent literature. Medicine (Baltimore) 73: 53-67, 1994.
6) Johnson RJ, Gretch DR, Yamabe H, et al. Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med 1993; 328: 465-470
7) Stehman-Breen C, Alpers CE, Couser WG, Willson R, Johnson RJ. Hepatitis C virus associated membranous glomerulonephritis. Clin Nephrol 1995; 44:141-7 .
8) Herbert L. Bonkovsky and Savant Mehta. Hepatitis C: a review and update. Journal of the American Academy of Dermatology 44: 159-179, 2001
9) El-Serag HB, Hampel H, Yeh C, Rabeneck L. Extrahepatic manifestations of hepatitis C among United States male veterans. Hepatology 2002;36:1439-45.
10) Kessel A, Rosner I, Zuckerman E, et al., Use of antikeratin antibodies to distinguish between rheumatoid arthritis and polyarthritis associated with hepatitis C infection. J Rheumatol 2000;27:610-2.
11) Zuckerman E, Yeshurun D, Rosner I. Management of hepatitis C virus-related arthritis. BioDrugs 2001; 15:573-84.
12) Hermine O, Lefrere F, Bronowicki JP,et al., Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection.
N Engl J Med 2002; 347:89-94.
13) Wilson SE, Lee WM, Murakami C et al., Mooren type hepatitis C virus associated corneal ulceration. Ophthalmology 1994, 101: 736-745. (Abstract)
Bless you Bill. Guys - it ain't all that bad... LOL! I mean - take a look at some of you folks - life has been really hard for you. I'm just lucky to have a great family and loving friends.
you sound like me, the golf ball clots are a tip ff to too much progesterne, the joint pain to inflammation possibly genetic...(grandma and ma did not have HCv so their arch to artritis would be later.
the plycystic ovary suggest the pituitary could be low, as that will cause ovarian cysts, AND inflammation and not enough thyroid or adrenal response to inflammation.
since many HCV people are extremely low on HGH you should get your IGF-1 tested as well as a full RA panel/Elisa etc. done.
JUst because you are done with treatment desn't mean your autoimmune system returns to normal, if it ever was.
Just because they may detect RA or Lupus will not mean the pituitary dysfunction....AKA now repair signal to joints and tissue each night, could not be at the root of it.
You could also have high iron which cause joint and muscle pain...did they monitor you for this during or since tx.??
maryB
oooooooooooooooooooooo sorry...my o key kept sticking, hpoe yu can read that..darn
OK - I'm going to put out my Quest Diagnostics Results...
Anyone - feel free to comment on these --- I'd like some opinons - or ideas...
I'll note those items that are OUT OF RANGE with *** and ALL CAPS
Lipid Panel Triglycerides 130
Cholesterol, Total 178
HDL CHOLESTEROL 38L****
LDL Cholesterol 114
Chol/DHLC Ratio 4.7
Comprehensive Metabolic panel w/ efgr glucose 96
UREA Nitorgen (Bun) 16
Creatinine 0.72
eGFR Non-Afr American >60
eGFR African American >60
Bun Creatinine ratio 22
Sodium 141
Potassium 4.8
Chloride 106
Carbon Dioxide 24
Calcium 9.3
Protein Total 7.3
Albumin 4.4
Globulin 2.9
Albumin / Globulin ratio 1.5
Bilirubin, Total 0.6
Alkaline Phosphatase 71
AST 17
ALT 22
HEPATIC FUNCTION PANEL
Protein, Total 7.3
Albumin 4.4
Globulin 2.9
Albumin/Globulin Ratio 1.5
Bilirubin Total 0.6
Bilirubin, Direct 0.1
Bilirubin, Indirect 0.5
Alkaline Phosphatase 71
AST 17
ALT 22
CBC (Include Diff/PLT)
White Blood Cell Count 6.8
RED BLOOD CELL COUNT 5.15 H******
HEMOGLOBIN 15.6 H*****
HEMATOCRIT 45.3 H*****
Mcv 88.1
Mch 30.3
Mchc 34.4
Rdw 13.8
Platelet Count 199
Absolute Neutrophils 4964
Abs. Lymphocytes 1265
Abs. Monocytes 408
Abs. Eosinophils 150
Absolute Basophils 14
Neutrophils 73.0
Lymphocytes 18.6
Monocytes 6.0
Eosinophils 2.2
Basophils 0.2
Anachoice (TM) Screen w/ REFL to TITER IFA ANACHOICE --- NEGATIVE
RHEUMATOID FACTOR 92 H *********************
C-Reactive Protein 0.17
Hemoglobin A1c 2ith MPG Hemoglobin Alc 5.5
Mean Plasma Glucose 119
________________________________________________________
Ok - so I know that I'm VERY happy with my Hepatic stuff... Dunno about the Blood cells and stuff --- but they aren't that far off from high range normal.
But I'm concerned about the Rheumatoid Factor.
I do understand that chronic Hep can cause some raise --- but that's pretty freaking high --- isn't it?
Ideas --- Am I right on the money with poss RA... Or some sort of muscular skeletal issues?
Doc hasn't discussed this with me yet - they just came in...
What other tests might you guys suggest?
Thanks - in advance for your help - thoughts and opinions.
Meki
I don't have any experience with the Rheumatoid factor, but I do have experience of post treatment soreness (worse during the winter than during our 9 mon. of the year warm FL weather). So, I'm thinking you live in Alaska, correct? Not that where you live would have any bearing on it, just curious about the cold coming into play. Also, I had a hysterectomy at 30 (but ovaries were left in) then, at approximately age 39, they had to go back in and take the ovaries and tubes. Prior to the 2nd surgery, my ovaries had shut down (treatment related??) I do not know. By the time, I'd had a couple of treatments under my belt already. I take Estrogen only (a plant based gel) and it does help to a certain degree. I tried to stop taking it for awhile and I had a lot more pain. So, with the blessing of both my Gastroenterologist and my Gynecologist, I am continuing on with the Estrogen only gel until I hit age 50 (a normal menopausal age), at which time, I will try to go to some type of natural hormone replacement that is a prescription that the doctor's office can prescribe. Anyway, I just wanted to share my story with you. I have no idea if it will help any or not. Susan
Thank you Susan... Sigh... I wish I could say this was just common soreness... But honestly - I feel like I'm 100 already and I'm only 41. I attributed it to HCV and just the INF and then my hysterectomy... But it's May... and it's getting progressively worse on a weekly basis.
But thank you so much for letting me know - I'll sincerely keep it in mind.
The doctor just called. They're going to try and get me set up with the Rheumatologist as soon as possible.
He said he has NEVER seen an Rheumatoid Factor so high --- and with the Ana-Choice, C-Reactive not representing he has concerns for other issues.
Greeeeeeeeeeeeeeeaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaat.
Now this means he hasn't seen a lot of Rheumatoid Factors or My count is off the freaking charts.
LOL! Go figure.
OK - I'm going to sit here and just freak out a little bit... Sigh.
Anyone?
I'm so sorry that you're in pain. Really. I also take Ultram (Tramadol) when I need to for pain. I can't take NSAIDS, so if it's too much soreness for Tylenol that I take the Ultram.
I hope you feel better soon and that they're able to get to the bottom of it for you.
Susan
Geez girl,
That is a lot for one person top have had to go through. I would definitely go see someone else about this if possible. It is tough when you deal with a doctor who is just not knowledgeable, even if he or she is a great person. I guess it is probably tough to find a good hep doctor in Alaska. But it sure must be beautiful up there!
I have to hand it to you as I read your posts often, despite it all you sure do manage to stay positive. My hat is off to you. I have always been the eternal optimist but lately i am getting cynical in my old age LOL.
I don't know about the RA stuff but that sure is a lot of *'s there!
OK - Flying over to Anchorage May 21st thru 23rd.
Guess I'm gonna be going through a Gamut of testing.
I'm developing an allergy to doctors.
I really have no idea on what the heck this will mean - but life is what it is....
LOL --- hey at least the HEP stuff came out AWESOME!
I'm VERY pleased with that...
Meki
Hey gal - sorry I've been out of touch - bad body week - guess you are experiencing a bit of my life eh?
My RA started 14 yrs ago with fever - body pain - then localized pain in the larger joints - shoulders, elbows etc. At several points could not walk - took 4 months to dx with regular docs - you need a GOOD Rumy - and make sure they are agressive - no wosey advil - you need to stop this in it's tracks (if you have it) or you could end up like I did 15 sugeries later.
RA is not a death sentence - these days the biogenetics like I'm on (Enbrel) are fabulous, very little sides and hardly any degeneration - but it is kind of like hearing you have HCV...a real blow.
But before we go there let me paste this for you about the RA factor (mine is 80+ usually)
Rheumatoid factors are antibodies directed against the Fc portion of immunoglobulin G (IgG). A positive test for rheumatoid factor is by no means pathognomonic of rheumatoid arthritis, but is present in 70 to 90% of patients with the disease. The titer does not correlate with the activity of disease, but patients with a high titer rheumatoid factor are more likely to have erosive joint disease, extra-articular manifestations, and greater functional disability. In contrast, generally, rheumatoid factor negative patients exhibit a milder disease course. Rheumatoid factors are also detectable in non-rheumatoid patients who have chronic antigenic stimulation, such as prolonged infection (bacterial endocarditis, tuberculosis, cytomegalovirus, human immunodeficiency virus (HIV), collagen vascular disease, or dysproteinemia).
They will also get sed rate. This is a good link for you to get general ifno and if you are dx with it let me know and we can chat.
http://www.hopkins-arthritis.org/arthritis-info/rheumatoid-arthritis/rheum_clin_pres.html#labo
Sorry you feel bad - (our bios are vey sililar - did you see mine on my profile?)
hugs...mikki
Thank You Mikki --- I'll know more in a couple of weeks... The hurry up and wait game again. LOL!
Mikki - do you think that you had HCV prior to RA?
Yep - I got it during a complete blood transfusion when I was 16. Been sick my whole life - one thing after another - constantly in the hospital with things they couldn't explain (they thought lupus, meningitis, graves, limes, etc), I've had all kinds of rashes, shingles, autoimmune problems, RA, Ostio, IBS, Scoliosis, Migrains, lost 1/3 of my large intestine - Ischimic Colitis, got autoimune bladder disease (Interstitial cystitis) Have sorjens (sp) hyatal hernia, mega cysts on ovaries and uterous (still on the pill to ease the cramps), Have major TMJ, very bad tinnitis, Colitis, mega cardiac problems and various metalic parts evenly distributed throughout my body - titanium rods in neck and feet - screws, bolts, wire...I'm real fun at the airport - ha...but hey up until this darn tx I was still riding and jumping my horses...(after 15 surgeries...but whose counting...actually it's 16 - just got one on my index finger - very apropriate for tx - looks like I'm flipping people off.)
Funny thing - my liver levels have been elevated for years and they always blammed it on the RA meds - didn't find out about HCV until this Jan when they had to test me for a new med. You'd think the fact that I was so sick that I had to stop work a year ago would of been a good indication something was up...They have been practicing medicine on me for a long time..