Question for Copyman

[toxy]

Congratulations with your HCV RNA Not Detected!!!!!!!!!!!!!!!!!!!!!!!
I am so happy for you
Please, tell us everything about your treatment
How long you were being treated?
Which Genotype you had?
Did you take Telepravir alone or with Interferon and Riba????
What side effects does it have????
My husband has Hep C genotype 3a and his liver is not damaged yet, do you think we better wait for Telepravir??
When will it come out approximately????

[Bill1954]

Here is the ’09 EASL (European Association for the Study of the Liver) data that JennyPenny is referring to, I believe; you might print this and use it as a discussion guide with your doctor—

http://www.natap.org/2009/EASL/EASL_13.htm

Bill

[JennyPenny2009]

I don't understand the reason why either. But here are is conclusion from the lastest geno 2 & 3 telaprevir studies.

"Conclusions: TVR demonstrated substantial antiviral activity against HCV G2, while its activity against G3 was limited. These findings support additional investigation of TVR for the treatment of G2 HCV infection. "

[toxy]

Is it really true, I do not understand if Telepravis works for Genotype 1 why it should not help Genotype 3???????

[jusjames]

2011 if no problems are found

[banarep]

am not copyman, but was on telaprevir as well.  According to Vertex, they are going to submit to the FDA in mid 2010.  I am in the Realize trial and we are just finishing up.  This trial was for nonresponders/relapsers/viral breakthroughs and Vertex wants/needs the information from out trial to submit to the FDA.  I was one of the last to get into the trial, and I finished last week - so the 24 week data will be availabe in about 7 months. then they will submit.  Time frame after that is about 1 year, so Telaprevir should come out on the market in mid 2011.  

Sides:  Biggest side for Telaprevir is therash.  But they have found ways to manage it, so my trial has had fewer dropouts.  

Time for treatment depends on genotype, viral response and if you have treated before.


First times genotype 1, if VL goes down (RVR) 24 weeks, if not 48 weeks.

retreaters genotype 1:  48 weeks.

do not know about the other genotypes.

telaprever does not work by itself, needs SOC as well.

[JennyPenny2009]

Telaprevir does not work on genotype 3 patients so there is no reason to wait. Interferon and ribavirin do very well all by themselves with geno 3's.

[newleaf09]

There was a recent post where a physician chimed in (a little red caduceus [snake on a staff...symbol of medicine] appeared by his name) and he thought the protease inhibitors like teleprevir and boceprevir would be available about this time next year.  Hard to say, since they are both jumping through FDA hoops now.  

There is a really good website called clinical care options that is written by physicians involved with HCV treatment.  It has great information and links to guidelines for doctors to use when treating patients with HCV.  It looks like a member-only site but isn't.  They just ask that you register and sign in when you use it.  Lots of other good info on the net, too at Janis & freinds and HCV advocacy sites.