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I relapsed on SOVALDI and Ribavirin
I have Hep-C G2.
Started SOVALDI and Ribavirin 12 week treatment Dec 23, 2013 (viral load at 2.5 million),
within 4 weeks into treatment my Hep C virus was undetectable.
12 weeks end of treatment my Hep C virus was undetectable.
4 weeks after treatment my Hep C virus was undetected.
12 weeks after of treatment my Hep C virus was detected at 83,000 viral load. It relapsed.
What are my chances of a cure now?
Started SOVALDI and Ribavirin 12 week treatment Dec 23, 2013 (viral load at 2.5 million),
within 4 weeks into treatment my Hep C virus was undetectable.
12 weeks end of treatment my Hep C virus was undetectable.
4 weeks after treatment my Hep C virus was undetected.
12 weeks after of treatment my Hep C virus was detected at 83,000 viral load. It relapsed.
What are my chances of a cure now?
I saw this info awhile back concerning relapsing, as part of a post on another forum. The poster appears to be VERY knowledgeable but the info is not substantiated (because the info comes from a subscription which is not available publically) so please consider that fact when reading. You can easily google part of the text below and find the original post and comments.
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"So why can Sovaldi patients relapse or fail treatment? A very small percentage stop treatment due to side effects. The Prescribing Information has listed various drugs that interfere with Sovaldi absorption and/or action. Other drugs may be added in time. Resistant mutations are the obvious answer. Up to recently, the only resistant mutation discovered was called S282T. Gilead steadfastly said this was only found in one patient who relapsed. This mutation is a change in the 282 protein, and evidently the variant with the S,T variation, interferes with action of the Sovaldi tri-phosphate. It rapidly mutates back to S282S which is not a problem. It has been shown that this S282T mutation can only occur in Genotypes 1b, 2a & b, and 3a. So, if you don't have those Genotypes, you would assume you were safe. Now, new RAV's have been found. M289L in Geno 2a, L159F in Geno 1a, 2b and C316N in Geno 1b. These are said to 'interfere' with the action of Sovaldi and lessen it's effectiveness. Post-transplant patients treated with Sovaldi developed a RAV called V321A but only those with Geno 3a. So it seems that Sovaldi has a very high barrier to resistance, but resistant mutations can indeed develop. This is why the second antiviral is required as backup. Although Ribavirin is a good antiviral, we still don't know exactly how it works, and it has side effects. The addition of another new DAA will give the best results, so Olysio has been given it's chance. When Ledispavir or Daclatasvir are approved, this will be the combo of choice, and we should be approaching the 100% SVR goal..Thanks for listening!"
-------------
"So why can Sovaldi patients relapse or fail treatment? A very small percentage stop treatment due to side effects. The Prescribing Information has listed various drugs that interfere with Sovaldi absorption and/or action. Other drugs may be added in time. Resistant mutations are the obvious answer. Up to recently, the only resistant mutation discovered was called S282T. Gilead steadfastly said this was only found in one patient who relapsed. This mutation is a change in the 282 protein, and evidently the variant with the S,T variation, interferes with action of the Sovaldi tri-phosphate. It rapidly mutates back to S282S which is not a problem. It has been shown that this S282T mutation can only occur in Genotypes 1b, 2a & b, and 3a. So, if you don't have those Genotypes, you would assume you were safe. Now, new RAV's have been found. M289L in Geno 2a, L159F in Geno 1a, 2b and C316N in Geno 1b. These are said to 'interfere' with the action of Sovaldi and lessen it's effectiveness. Post-transplant patients treated with Sovaldi developed a RAV called V321A but only those with Geno 3a. So it seems that Sovaldi has a very high barrier to resistance, but resistant mutations can indeed develop. This is why the second antiviral is required as backup. Although Ribavirin is a good antiviral, we still don't know exactly how it works, and it has side effects. The addition of another new DAA will give the best results, so Olysio has been given it's chance. When Ledispavir or Daclatasvir are approved, this will be the combo of choice, and we should be approaching the 100% SVR goal..Thanks for listening!"
Main reason I switched dr was first guy I was seeing was swamped. If I had appt at 1300 wouldn't see doc until 1530 or later. Peace
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