Aa
If the Hemopurifier being tested by AEMD in India is able to reduce viral loads in blood of HCV ?
If the Hemopurifier being tested by AEMD in India is able to reduce viral loads in blood of HCV infected subjects, then how could this not be anything but helpful?
I am sure that it is not cure because not every copy of the virus is in the blood.
There are likely only a small percentage that in the blood.
But from the virus''s point of view , is it not a numbers game.
Because the reason that a person's own immune system can not rid the body of the virus is because the virus keeps mutating? The only way it can mutate is by making lose copies of it self in high numbers until one copy figures out how to defeat the immune system. Right? And then natural selection will of coarse favor that copy of that virus and it will survive and multiply until the immune system figures out how to defeat it and then the virus will have another mutant copy that natural selection will favor. And the war goes on.
At least that is how I think it works. So if a person could even reduce their viral load in there blood by 1% then
would that not decrease the odds of one of the losely made copies of the virus becoming the new mutant strain?
Of coarse if that is true then Blood letting would likely reduce the viral load in the blood by 1%.
I am not advocating the return to middle evil medicine .
But it makes so much sense to me that if the Hemopurifier does being down the load then it would definately be of great help before starting any treatment.
Unless I got it all wrong and virus's really do their thing though the aide of some sort of divine intelligence for the outside that guides their mutation.
I have no knowledge or training in medicine of any kind, so I can only look at the problem of HCV
in the way a statistic would, or a game theorist.
Can someone please straighten me out and tell me where I am wrong?
I am sure that it is not cure because not every copy of the virus is in the blood.
There are likely only a small percentage that in the blood.
But from the virus''s point of view , is it not a numbers game.
Because the reason that a person's own immune system can not rid the body of the virus is because the virus keeps mutating? The only way it can mutate is by making lose copies of it self in high numbers until one copy figures out how to defeat the immune system. Right? And then natural selection will of coarse favor that copy of that virus and it will survive and multiply until the immune system figures out how to defeat it and then the virus will have another mutant copy that natural selection will favor. And the war goes on.
At least that is how I think it works. So if a person could even reduce their viral load in there blood by 1% then
would that not decrease the odds of one of the losely made copies of the virus becoming the new mutant strain?
Of coarse if that is true then Blood letting would likely reduce the viral load in the blood by 1%.
I am not advocating the return to middle evil medicine .
But it makes so much sense to me that if the Hemopurifier does being down the load then it would definately be of great help before starting any treatment.
Unless I got it all wrong and virus's really do their thing though the aide of some sort of divine intelligence for the outside that guides their mutation.
I have no knowledge or training in medicine of any kind, so I can only look at the problem of HCV
in the way a statistic would, or a game theorist.
Can someone please straighten me out and tell me where I am wrong?
Hi marcia I think thats exactly what Aethlon are recommending it for-an adjunctive treatment supporting anti viral therapy. I suppose doing say 10 sessions on the filter then clobbering the virus with STAT C regimen would be effective.
I'm actually quite interested in anything that might give me a better chance of achieving SVR. Theres nothing wrong with thinking outside the box, I would like to see their data in the future.
I'm actually quite interested in anything that might give me a better chance of achieving SVR. Theres nothing wrong with thinking outside the box, I would like to see their data in the future.
The thing is, all the information about the thing is generated in-house. I'd like to see independent analsysis. All the experts seem to be assocaiated with the company.
My intuition is that AEMD might on to something.
Everybody has told me that HCV virus does not replicate in the Blood so the hepa filter would not help by removing the virus from the blood.
To counter that argument I would suggest that they first figure out exactly how Interferon works. I bet it ONLY works in the liver, with the T-cells ect.
But it does not help kill any of the viruses in the blood steam. So the liver is constantly getting reinfected by the ones own blood. Those people that did get a sustand response only did so because they were able to kill all the viruses in the liver for a long enough time that those in the blood stream died of old age and were not there to re-infect the liver.
If that were the case then it really would be helpful to physically filter the viruses out of the blood.
Now I just made that all up. I am not a doctor or a researcher.
But if HCV were easy to cure then it would be cured by now.
It will require somebody like AEMD to think out of the box and try something different . And the fact that almost all of the researchers say that ''It can not work because the virus replicates in the liver not the blood"" makes me think that AEMD really needs to continue their research. Remember that all the researchers read the same medical books and probably think much in the same way. After all they all decided to get into Medical research. Right? They might all be suffering a bad case of group think? I would love to have a few really smart people that are not medical researchers think about the problem just to see what their suggestions would be in the attempt to try something different. This war will be won by someone thinking out of the box.
Maybe the virus has some kind of life cycle that requires it to be the blood or have the presence of blood in order to replicate? IDNK.
But I do know that those that put 100% of their faith in those that have failed to come up with a 99% cure to this thing are stupid to discourage
real research that does not follow the excepted path.
I believe that Louis Pastures''s suggestion that Doctors wash their hands before operating was considered un- scientific and NOT based on research or even common sense.
What do think?
Everybody has told me that HCV virus does not replicate in the Blood so the hepa filter would not help by removing the virus from the blood.
To counter that argument I would suggest that they first figure out exactly how Interferon works. I bet it ONLY works in the liver, with the T-cells ect.
But it does not help kill any of the viruses in the blood steam. So the liver is constantly getting reinfected by the ones own blood. Those people that did get a sustand response only did so because they were able to kill all the viruses in the liver for a long enough time that those in the blood stream died of old age and were not there to re-infect the liver.
If that were the case then it really would be helpful to physically filter the viruses out of the blood.
Now I just made that all up. I am not a doctor or a researcher.
But if HCV were easy to cure then it would be cured by now.
It will require somebody like AEMD to think out of the box and try something different . And the fact that almost all of the researchers say that ''It can not work because the virus replicates in the liver not the blood"" makes me think that AEMD really needs to continue their research. Remember that all the researchers read the same medical books and probably think much in the same way. After all they all decided to get into Medical research. Right? They might all be suffering a bad case of group think? I would love to have a few really smart people that are not medical researchers think about the problem just to see what their suggestions would be in the attempt to try something different. This war will be won by someone thinking out of the box.
Maybe the virus has some kind of life cycle that requires it to be the blood or have the presence of blood in order to replicate? IDNK.
But I do know that those that put 100% of their faith in those that have failed to come up with a 99% cure to this thing are stupid to discourage
real research that does not follow the excepted path.
I believe that Louis Pastures''s suggestion that Doctors wash their hands before operating was considered un- scientific and NOT based on research or even common sense.
What do think?
I got HCV
I have been through two treatments with INT / PEG and am a non responder.
I own 1000 shares of AEMD and have owned it for over 6 years.
I bought 500 shares at $.26 and 500 shares at $.41. and I own the shares with my Roth IRA. account with Ameritrade
I bought them because I think their research is worth doing.
I could have given $500.00 to the liver foundation but I think that buying this stock was a better use of my money.
If the filter works, then I will make some money and that is good because then I will likely live longer and need more money.
If it does not, then I figure ***** it. The research was worth trying anyway.
This company is very small and very broke. They can not make a profit until their devise is brought to market. They are very effient with their cash available. This I know.
AT Least THEY must believe in their chances of it working or they would have pissed away all their cash on a company Christmas party and filed bankruptcy like other fly by night research companies.
I think this company does have enough cash on their balance sheet to see this thing through. So I think that at least then we will know. But it will be close.
If you would like to help make sure that this company stays solvent long enough to see if this thing really works then please consider buying 1000 shares of it yourself. If it works then you could easily get a 10 fold return on your money, if not, then at least we will all know what does NOT work. The current stock price is $.18 a share.
1000 shares will only cost you $180.00.
It would be a shame if they run out of capital before they get the data they need to know
if their crazy idea has any merit. Most of the company shares are own by its employees so they are all just as hopeful as I am.
Bruce
I have been through two treatments with INT / PEG and am a non responder.
I own 1000 shares of AEMD and have owned it for over 6 years.
I bought 500 shares at $.26 and 500 shares at $.41. and I own the shares with my Roth IRA. account with Ameritrade
I bought them because I think their research is worth doing.
I could have given $500.00 to the liver foundation but I think that buying this stock was a better use of my money.
If the filter works, then I will make some money and that is good because then I will likely live longer and need more money.
If it does not, then I figure ***** it. The research was worth trying anyway.
This company is very small and very broke. They can not make a profit until their devise is brought to market. They are very effient with their cash available. This I know.
AT Least THEY must believe in their chances of it working or they would have pissed away all their cash on a company Christmas party and filed bankruptcy like other fly by night research companies.
I think this company does have enough cash on their balance sheet to see this thing through. So I think that at least then we will know. But it will be close.
If you would like to help make sure that this company stays solvent long enough to see if this thing really works then please consider buying 1000 shares of it yourself. If it works then you could easily get a 10 fold return on your money, if not, then at least we will all know what does NOT work. The current stock price is $.18 a share.
1000 shares will only cost you $180.00.
It would be a shame if they run out of capital before they get the data they need to know
if their crazy idea has any merit. Most of the company shares are own by its employees so they are all just as hopeful as I am.
Bruce
I brought up this subject last Dec & wow what a discussion, negativity, name calling until some posts deleted ... emotions ran high is some folks. There was also some good input.
I was just trying to collect information & opened the proverbial "can of worms".
Here's the link to that discussion for those of you who have some time and want to read how emotional folks can get ...
http://www.medhelp.org/posts/Hepatitis-C/Hemopurifier-or-VRAD/show/1118968
For those of you that don't yet know , DFPP is very similar to Hemopurification .. Double Plasmapheresis Filtration , it has been researched with Trials in Japan and found to be helpful enough in HCV Tx that the Japanese Govt . supports it and helps to pay the bills for their citizens.
Nobody says it is a cure , only that the filtration approach helps in clearing and achieving SVR in conjunction with SOC Tx , anyone opposed to that .. must have a personal problem. Attitude problem's do not help anyone here , we are all in this together. Constructive criticism is ok , normal, however anything more than that is destructive and non productive.
For the non biased clinical information Flguy and others are asking for ... link to the following webpage. The information is available ... you just have to look ...
Links to : Scholarly review's: Use of Double Filtration Plasmapheresis in HCV treatment :
http://scholar.google.com/scholar?q=DFPP+hcv+treatment+japan&hl=en&as_sdt=0&as_vis=1&oi=scholart
Another review : from 2007
http://onlinelibrary.wiley.com/doi/10.1111/j.1872-034X.2007.00117.x/abstract
Aim: The efficacy and safety of double filtration plasmapheresis (DFPP) plus interferon (IFN) combination therapy were compared with those of IFN therapy alone in 193 chronic hepatitis C patients having a high hepatitis C virus ribonucleic acid load of difficult-to-treat genotype 1b.
Methods: All patients received either interferon alpha-2b (IFN-α-2b) monotherapy or combination therapies with ribavirin and IFN-α-2b or pegylated interferon alpha-2b (PEG-IFN-α-2b). Each patient individually decided whether to receive concomitant DFPP. DFPP was immediately followed by IFN treatment, and up to five sessions were given during the first week.
Results: Sixty patients decided to receive DFPP. In the DFPP plus PEG-IFN-α-2b therapy group (n = 30), viral load reduction at 4 weeks after the start of treatment was greater than innon-DFPP (n = 74) (2.47 vs 1.52, log, P = 0.010), and the sustained virus response was also higher (77.8% vs 50.0%), even in cases of re-treated patients (relapsers or non-responders to previous IFN therapies). Adverse events, mild and transient, were observed in 38.3% of all DFPP-treated patients.
Conclusion: DFPP plus IFN combination therapy produced a great reduction of viral load during the early stage of treatment and achieved a high sustained virus response, suggesting that this combination therapy may be a new modality for chronic hepatitis C patients at difficult-to-treat states.
I wish all the best success to the U.S. equivalent AEMD !
I was just trying to collect information & opened the proverbial "can of worms".
Here's the link to that discussion for those of you who have some time and want to read how emotional folks can get ...
http://www.medhelp.org/posts/Hepatitis-C/Hemopurifier-or-VRAD/show/1118968
For those of you that don't yet know , DFPP is very similar to Hemopurification .. Double Plasmapheresis Filtration , it has been researched with Trials in Japan and found to be helpful enough in HCV Tx that the Japanese Govt . supports it and helps to pay the bills for their citizens.
Nobody says it is a cure , only that the filtration approach helps in clearing and achieving SVR in conjunction with SOC Tx , anyone opposed to that .. must have a personal problem. Attitude problem's do not help anyone here , we are all in this together. Constructive criticism is ok , normal, however anything more than that is destructive and non productive.
For the non biased clinical information Flguy and others are asking for ... link to the following webpage. The information is available ... you just have to look ...
Links to : Scholarly review's: Use of Double Filtration Plasmapheresis in HCV treatment :
http://scholar.google.com/scholar?q=DFPP+hcv+treatment+japan&hl=en&as_sdt=0&as_vis=1&oi=scholart
Another review : from 2007
http://onlinelibrary.wiley.com/doi/10.1111/j.1872-034X.2007.00117.x/abstract
Aim: The efficacy and safety of double filtration plasmapheresis (DFPP) plus interferon (IFN) combination therapy were compared with those of IFN therapy alone in 193 chronic hepatitis C patients having a high hepatitis C virus ribonucleic acid load of difficult-to-treat genotype 1b.
Methods: All patients received either interferon alpha-2b (IFN-α-2b) monotherapy or combination therapies with ribavirin and IFN-α-2b or pegylated interferon alpha-2b (PEG-IFN-α-2b). Each patient individually decided whether to receive concomitant DFPP. DFPP was immediately followed by IFN treatment, and up to five sessions were given during the first week.
Results: Sixty patients decided to receive DFPP. In the DFPP plus PEG-IFN-α-2b therapy group (n = 30), viral load reduction at 4 weeks after the start of treatment was greater than innon-DFPP (n = 74) (2.47 vs 1.52, log, P = 0.010), and the sustained virus response was also higher (77.8% vs 50.0%), even in cases of re-treated patients (relapsers or non-responders to previous IFN therapies). Adverse events, mild and transient, were observed in 38.3% of all DFPP-treated patients.
Conclusion: DFPP plus IFN combination therapy produced a great reduction of viral load during the early stage of treatment and achieved a high sustained virus response, suggesting that this combination therapy may be a new modality for chronic hepatitis C patients at difficult-to-treat states.
I wish all the best success to the U.S. equivalent AEMD !
One thing is for sure, Americans tend to take a pill for everything. So, given that Japan's DFPP and Aethlon's Hemopurifier are not pills, it has met and will continue to meet significant resistance here and elsewhere.
But, for the sake of those who need it, hopefully the treatments about to start at Medanta will show that the Hemopurifier does significantly improve response to the current drug therapy. This would be great news for all who have Hep C, given how toxic current drug therapies are, and great news particularly for those who have not responded to the drug therapy.
The next 12 months should reveal quite a bit on this front.
But, for the sake of those who need it, hopefully the treatments about to start at Medanta will show that the Hemopurifier does significantly improve response to the current drug therapy. This would be great news for all who have Hep C, given how toxic current drug therapies are, and great news particularly for those who have not responded to the drug therapy.
The next 12 months should reveal quite a bit on this front.
Have an Answer?
You are reading content posted in the Hepatitis C Community
Learn about this treatable virus.
Getting tested for this viral infection.
3 key steps to getting on treatment.
4 steps to getting on therapy.
What you need to know about Hep C drugs.
How the drugs might affect you.
These tips may up your chances of a cure.
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.
