METROPOLOl VS NADOLOL ok with Cirrhosis?

[FRED220]

I currently take half of 25mg of Metropolol in the mornings for arrythmias and have noticed that my ALT and AST levels where higher in my last blood work since I started taking Metropolol. Now my Doctor wants to change me to Nadolol but could not answer me if the meds do increase the liver enzymes. Like to know if anyone had this happen to them or heard about it.  

[FRED220]

My AST went from 48 to 118  and AST from 88 to 184.

[AWorriedMom]

Mild elevations can come with almost any drug that is metabolized in the liver.,I wouldnt think this would be a problem unless the elevations were severe and then your doctor would take you off. Just how high were these elevations?

[FRED220]

I failed  to mention it was my cardio doc that prescribed me the meds. I did some research this afternoon and Metropolol does elevate ALT and AST levels but they come down when you stop  I have appt with  EP this coming week since I am having some arrythmia problems and I am trying to find out whats going on.Maybe is all the stress with this crazy meds approval etc.  Wishing you both a great New Year and SVR soon:)  

[flyinlynn]

I did find this about Nadolol

Long-term effect of nadolol on quantitative liver function tests in patients with cirrhosis

Summary

Nadolol, a non-cardioselective beta adrenoreceptor blocking agent, has been reported to decrease portal pressure without affecting liver function in cirrhotic patients treated for 1 month. There were no data about the long-term effects of nadolol on liver function.

In 11 patients with cirrhosis and portal hypertension galactose eliminating capacity, aminopyrine metabolic capacity, ICG clearance and IGC intrinsic hepatic clearance according to the “parallel tube” model were measured before and after 6 months of treatment with nadolol at a dose reducing resting heart rate by approximately 25%. No significant variation in any of these parameters was found.

Thus 6 months of continuous oral administration of nadolol did not further impair liver function in cirrhotics.

[AWorriedMom]

I have cirrhosis and have been on much higher doses of metoprolol for at least 10 years. It never bothered my liver enzymes. A hallmark of hepatitis C is fluctuating levels of AST and ALT. I would doubt it is your bp meds unless the elevations were very big after you started the drug.

[flyinlynn]

Hi Fred

Is your doctor a liver specialist? If he is and he is prescribing you a med and he does not know if the med will affect your liver that is kinda scary.