Aa
Maintenance Therapy
Scott (revenire) had said that he was considering "maintenance therapy" when he relapsed after 88 weeks of tx. The following trials are underway for maintenance therapy to reduce or slow the progression of HCV disease:HALT-C, EPIC-3, COPILOT, PROI-C, AEGIS. The data that I'm finding is early. Does anyone have any data about the effectiveness of maintenance therapy?
Both of you are absolute Loons!! Chev, we know you are a sex deprived nympho, but do you have to swing off Rev's pathetic little *****?
Who the hell is jumping on magic beans? I'm on tx. I'm killing my dragon.
Who is intimidated to speak up, many because of the childish bullshit both of you just demonstarted.
Mother issues, is that your reasoning? Nothing else to try and rub my face in. I am strong, and moved on. I love my mom, but she can not have any part in my life, where done. I don't need a tissue, or an excuse, I move forward. Can you?
As far as your study, read only what you want. You are lingering on one study. Blaming your relapse on it. Well we can both pull together 10 or more other studies to contradict it.
Enemy? Who was one of the first to offer their support to you Rev? When I heard the news, I WAS devastated. Nobody deserves that. You always need some excuse or finger pointing when you can't win an argument. Don't give me this **** about trying to be amusing, you are acting like the little b*tch you have proven so many times to be. No one needs to argue or debate with you, nobody can. Your mental retardation, or brain under development has denied you from any further education. You are trapped in a world of self delusion. Rev, you are not a leader. I tried to fill you with some confidence, cause you are obviously just overwhelmed and depressed, it shows.
Your response and immaturity prove the exact point I have always stated, your a pathetic little angry looser. Your probably some little guy who sits by himself, a loaner with no friends. You speak out on the computer because in real life you can't. Rev, if we are enemies, I pity you more. The falling down and division in America that you speak about is never been so evident. Despite our diferences, I have extended my hand numerous times, and offered encouragement and friendship. I am infected with HCV, so are you. We ARE brothers, not enemies.
When you remember that,you can start focusing back on the TRUE enemy, HCV..
Who the hell is jumping on magic beans? I'm on tx. I'm killing my dragon.
Who is intimidated to speak up, many because of the childish bullshit both of you just demonstarted.
Mother issues, is that your reasoning? Nothing else to try and rub my face in. I am strong, and moved on. I love my mom, but she can not have any part in my life, where done. I don't need a tissue, or an excuse, I move forward. Can you?
As far as your study, read only what you want. You are lingering on one study. Blaming your relapse on it. Well we can both pull together 10 or more other studies to contradict it.
Enemy? Who was one of the first to offer their support to you Rev? When I heard the news, I WAS devastated. Nobody deserves that. You always need some excuse or finger pointing when you can't win an argument. Don't give me this **** about trying to be amusing, you are acting like the little b*tch you have proven so many times to be. No one needs to argue or debate with you, nobody can. Your mental retardation, or brain under development has denied you from any further education. You are trapped in a world of self delusion. Rev, you are not a leader. I tried to fill you with some confidence, cause you are obviously just overwhelmed and depressed, it shows.
Your response and immaturity prove the exact point I have always stated, your a pathetic little angry looser. Your probably some little guy who sits by himself, a loaner with no friends. You speak out on the computer because in real life you can't. Rev, if we are enemies, I pity you more. The falling down and division in America that you speak about is never been so evident. Despite our diferences, I have extended my hand numerous times, and offered encouragement and friendship. I am infected with HCV, so are you. We ARE brothers, not enemies.
When you remember that,you can start focusing back on the TRUE enemy, HCV..
Rev, I am not the only person on this forum that is disturbed by what you are trying to lay out. Many just are afraid or too intimidated to speak up. Go back up and read what you posted. What it came across as, was that if a person has moderate or severe fibrosis even after SVR, the virus lays dormait or hides in the livers scar tissue. A false PCR.. Is this not what you stated? Why the hell are any of us doing tx if the virus just hides and there is no cure? Do you realize what you are saying?
Many memebers here have ESLD or chirrosis, and obtained SVR. These memebers remained SVR, and continue to live HCV free. Just because you relasped for whatever reason your Dr has milked your prostate with, don't try to bullshit us. If that was correct, why do any of us treat? Why don't all of us just follow your Dr's advice, and maintain? If we have damage, and there is no hope such as you stated, why go through it right? Please, now is your chance to correct yourself, and try to MAINTAIN a little bit of credibility.
I understand your frustration of relaspe. None of us deserve such a hardship, even you. Anyone who fought as long as you should have reached SVR, and freed themselves from HCV for good. But life has away of playing hardball. All we can do is keep fighting, or crawl into a whole like a rat!
I do ALOT of research myself.. I have read ever study that is posted above, and probably more. I am on every weekly HCV news letter, and I get every update on HCV related bills that go to Congress. What happened to you, is a fluke. Your Dr is scratching his head and wondering himself what happened. Unfortunately he has to give you an answer, so he attempted to give you his best explanation. What we all know about this disease, is there is absolutely NO rythme or reason. NONE!! Every case is different, EVERY person reacts different.
What we also know from many of the EXACT same sites you reference above, is supplementation does help HALT progression. Milk thistle has a protective agent that works so well to protect the liver, the new studies suggest many not to take it if on certain medications as it does not let the meds to filter properly through the liver. That is why many Dr's tell you not to take it while on TX. Vitamin E, and C, have shown to halt and Reverse fibrosis in lab rats. NAC, has shown to stimulate interferon and actually HELP it regenerate liver tissue in patients on pegylated interferon/riba tx. Many studies on that. Many studies on patients who took just vitamin C and E along with tx, and achieved SVR with greater % than people who did not. You can hide your head in a hole and blame everything in the world, but truth is you responded.. Treatment did what it was supposed to by all standards. You had drop in VL, went undetectable, and stayed undetectable. You just relaspsed. Now you gotta see where your liver stands, probably alot better, and either go at it again, or give in to a Dr that is in the business to TREAT, not cure.
Question you gotta ask yourself, is do you wanna be free? Do you wanna kill this DRAGON? You once said to me, that the worst fear you have is passing it to your wife or children possibly in a car accident or from some other accident. Do you remember? What has changed?
Find out the condition of your liver, whether or not you reversed some damage, get your fighting face back on, and kill that f##ker. Don't give us this sh*t about if there is fibrosis, we are all doomed. I'm not falling for it. Studies and other memebers here, have proved that wrong, LIFE has proved that wrong.
Open your eyes my man, and show us that confidence you use to have. Not this my Dr knows eyerything, and I'll follow him too the moon. I know your not a follower, we all know your not a follower, prove to us again that you can lead.
Many memebers here have ESLD or chirrosis, and obtained SVR. These memebers remained SVR, and continue to live HCV free. Just because you relasped for whatever reason your Dr has milked your prostate with, don't try to bullshit us. If that was correct, why do any of us treat? Why don't all of us just follow your Dr's advice, and maintain? If we have damage, and there is no hope such as you stated, why go through it right? Please, now is your chance to correct yourself, and try to MAINTAIN a little bit of credibility.
I understand your frustration of relaspe. None of us deserve such a hardship, even you. Anyone who fought as long as you should have reached SVR, and freed themselves from HCV for good. But life has away of playing hardball. All we can do is keep fighting, or crawl into a whole like a rat!
I do ALOT of research myself.. I have read ever study that is posted above, and probably more. I am on every weekly HCV news letter, and I get every update on HCV related bills that go to Congress. What happened to you, is a fluke. Your Dr is scratching his head and wondering himself what happened. Unfortunately he has to give you an answer, so he attempted to give you his best explanation. What we all know about this disease, is there is absolutely NO rythme or reason. NONE!! Every case is different, EVERY person reacts different.
What we also know from many of the EXACT same sites you reference above, is supplementation does help HALT progression. Milk thistle has a protective agent that works so well to protect the liver, the new studies suggest many not to take it if on certain medications as it does not let the meds to filter properly through the liver. That is why many Dr's tell you not to take it while on TX. Vitamin E, and C, have shown to halt and Reverse fibrosis in lab rats. NAC, has shown to stimulate interferon and actually HELP it regenerate liver tissue in patients on pegylated interferon/riba tx. Many studies on that. Many studies on patients who took just vitamin C and E along with tx, and achieved SVR with greater % than people who did not. You can hide your head in a hole and blame everything in the world, but truth is you responded.. Treatment did what it was supposed to by all standards. You had drop in VL, went undetectable, and stayed undetectable. You just relaspsed. Now you gotta see where your liver stands, probably alot better, and either go at it again, or give in to a Dr that is in the business to TREAT, not cure.
Question you gotta ask yourself, is do you wanna be free? Do you wanna kill this DRAGON? You once said to me, that the worst fear you have is passing it to your wife or children possibly in a car accident or from some other accident. Do you remember? What has changed?
Find out the condition of your liver, whether or not you reversed some damage, get your fighting face back on, and kill that f##ker. Don't give us this sh*t about if there is fibrosis, we are all doomed. I'm not falling for it. Studies and other memebers here, have proved that wrong, LIFE has proved that wrong.
Open your eyes my man, and show us that confidence you use to have. Not this my Dr knows eyerything, and I'll follow him too the moon. I know your not a follower, we all know your not a follower, prove to us again that you can lead.
thanks Mike for that one, any one knows what interferon was used?
I was wondering if pegylation makes any difference.
Why aren't more people's hcv replicating after their SVR, then? Is this "leftover" hcv even a functional virus?
I just don't see many studies showing positive hcv in the serum after years of SVR, so makes you wonder if these findings in the 17 subjects is even significant. I guess that is why they always ask for reproduction of results in these studies by a separate source.
I was wondering if pegylation makes any difference.
Why aren't more people's hcv replicating after their SVR, then? Is this "leftover" hcv even a functional virus?
I just don't see many studies showing positive hcv in the serum after years of SVR, so makes you wonder if these findings in the 17 subjects is even significant. I guess that is why they always ask for reproduction of results in these studies by a separate source.
PERSISTENCE OF HEPATITIS C VIRUS IN PATIENTS SUCCESSFULLY TREATED FOR CHRONIC HEPATITIS C
Marek Radkowski, Mayo Clinic Scottsdale, Scottsdale, AZ; Joanna Jablonska, Warsaw Medical Academy, Warsaw, Poland; Jeffrey Wilkinson, Thomas V. Colby, Mayo Clinic Scottsdale, Scottsdale, AZ; Bozena Walewska-Zielecka, National Institute of Hygiene, Warsaw, Poland; Debra M. Adair, Jorge Rakela, Tomasz Laskus, Mayo Clinic Scottsdale, Scottsdale, AZ.
Introduction:
It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV) infection results in complete elimination of the virus.
Methods:
We studied 17 patients with chronic hepatitis C who had sustained virological response (SVR) after IFN/Ribavirin treatment (HCV RNA negative in serum 6 months after treatment by Amplicor HCV ver. 2.0; sensitivity limit 100 viral copies/mL). Serum and peripheral blood mononuclear cells (PBMC) were collected 2-3 times at 3-6 month intervals starting 40-109 months (mean 64.2
Marek Radkowski, Mayo Clinic Scottsdale, Scottsdale, AZ; Joanna Jablonska, Warsaw Medical Academy, Warsaw, Poland; Jeffrey Wilkinson, Thomas V. Colby, Mayo Clinic Scottsdale, Scottsdale, AZ; Bozena Walewska-Zielecka, National Institute of Hygiene, Warsaw, Poland; Debra M. Adair, Jorge Rakela, Tomasz Laskus, Mayo Clinic Scottsdale, Scottsdale, AZ.
Introduction:
It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV) infection results in complete elimination of the virus.
Methods:
We studied 17 patients with chronic hepatitis C who had sustained virological response (SVR) after IFN/Ribavirin treatment (HCV RNA negative in serum 6 months after treatment by Amplicor HCV ver. 2.0; sensitivity limit 100 viral copies/mL). Serum and peripheral blood mononuclear cells (PBMC) were collected 2-3 times at 3-6 month intervals starting 40-109 months (mean 64.2
Poor Rev.. I guess we couldn't expect anything more from you. You didn't have enough insight to research your candidate, and you still overlook the facts of research on HCV.
Are you that ingnorant, or just scared? You have to be kidding right? Ok, we'll wipe the slate, and you can correct yourself right now.
Do you understand the consept of what ALT's measure? If you can stabilize ALT levels, liver cell destruction is not happening. The vitamin protocol I took for 6 months, stabilzed my ALT's, lowered my VL, and raised my platelets and CBC's. My mother took the same, and her VL went from 4.1 million, to 2.3 million. ALT's also dropped.
No magic bean, as you seem to linger on, just supplements PROVEN to reduce inflamation and free radical damage.The VL drops, I can not say whether they where just fluctuations, or dou to supplements, just that they happened.
If you ever open your eyes, wanna make a decision based on RESEARCH like you claim to always go by, email me and I'll point you to some links. Hey, you are waiting six months to restart anyway, take the supplements and see what happens till then. Get your head outta that Dr's arse, it's effecting your judgement.
Are you that ingnorant, or just scared? You have to be kidding right? Ok, we'll wipe the slate, and you can correct yourself right now.
Do you understand the consept of what ALT's measure? If you can stabilize ALT levels, liver cell destruction is not happening. The vitamin protocol I took for 6 months, stabilzed my ALT's, lowered my VL, and raised my platelets and CBC's. My mother took the same, and her VL went from 4.1 million, to 2.3 million. ALT's also dropped.
No magic bean, as you seem to linger on, just supplements PROVEN to reduce inflamation and free radical damage.The VL drops, I can not say whether they where just fluctuations, or dou to supplements, just that they happened.
If you ever open your eyes, wanna make a decision based on RESEARCH like you claim to always go by, email me and I'll point you to some links. Hey, you are waiting six months to restart anyway, take the supplements and see what happens till then. Get your head outta that Dr's arse, it's effecting your judgement.
Thanks for that article, in ALL tests we take OUR "normal" might not be the same as the average normal for most,
It would seem that to determine mine, I would need records from many years ago and compare to post dx range, and then post tx ones.
So when people comment that they halt their liver damage with alternatives, do you think it is accurate to decide that based on the enzymes readings?
It would seem that to determine mine, I would need records from many years ago and compare to post dx range, and then post tx ones.
So when people comment that they halt their liver damage with alternatives, do you think it is accurate to decide that based on the enzymes readings?
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