Does Anyone else out there have Multiple Genotypes?

[QWC]

I was diagnosed with hep C 6 years ago.  I recently found out through a new blood test via a new Hep G.I.  doc that I (although they told me six years ago I was just Genotype 1, when I had my biopsy)  have not only Genotype 1a, BUT.... ALSO Genotype 2.  I am trying to find ANYONE else who has 'this' or any "Multiple Genotypes" as the test results said it is "a very rare condition" and "somewhat unusual" .  There is no way I could have been reinfected because I caught it from my then boyfriend, now fiancee, don't do drugs, and have not been around anyone else with hep C.  I am going to have my fiancee get the same test to see, because the only evidence or barely just one sentence of literature that I've been able to find said that Genotypes do not change.  So I am presuming that the test six years ago was not as good, or the other genotype not as prevalent.  I just really want to "find" and "Talk" to another soul who has this as well.  Anyone?????   Q

[QWC]

Thank You all, for your prompt great info, I don't feel so lost now.  I cannot take interferon OR ribaviron, so, I will wait as my doc said to do.  Hopefully, the treatment will only get better.  

[flyinlynn]

Hi

I have the link for Sovaldi prescribing information.

http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/sovaldi/sovaldi_pi.pdf

and also the AASLD hep c treatment guidelines

http://www.hcvguidelines.org/sites/default/files/full_report.pdf

I tend to agree with Bluemetal that the medicine will get both varients at the same time. And I as a lay person don't believe it would necessarily mean a longer treatment. Also hair loss is mostly associated with interferon so no worries there.

I haven't seen if you have said what treatment you will be using but for GT 2 the treatment is Sovaldi + Ribavirin for 12 weeks with overall results of 95% depending on which trial results you are looking at.

For GT 1 either Sovaldi + interferon/ribavirin overall results at 89%  or Sovaldi Olysio +/- ribavirin for 12 weeks overall results between 86-100% based on multiple factors. So my best guess would be Sovaldi + Olysio + ribavirin for 12 weeks should get them both.

On the Daclatasvir Sovaldi combo looks like about 98% for GT1 and 92% for GT 2 and is also in for FDA approval hopefully this fall.

Good Luck
Lynn

[QWC]

I know you are also right , Idyllic.  I have stopped my initial "freak-out" and accepted it, but won't stop my search to even get to "talk" to someone else who has had this.  Many of the doctors I have come across seem to know less about this disease than we do--I guess when you want to be cured so badly, it becomes a full-time job.  I know that the fact that there is (2) probably means a longer treatment, and I am so afraid of treatment, especially losing my hair--that would be so psychologically traumatizing to me--it is just a thing with me.  (My dad went bald in his thirties, and when my Mom lost all her hair from chemo, it never grew back.)  --I know it would increase my depression horribly.  The doctors I have come across do not care about this and I presume they also do not know how long to treat a "multiple", (that it will be a guessing game)--especially since in my frantic searching in the past couple weeks, have not been able to find "any" SVR statistics on people being cured who have Multiple Gts, except to read that it usually makes the virus all that much more resistant.  That is why I would Love to be able to find and talk to another human patient who has or has had this case of multiple gts to get an idea of how much more resistant we are talking about.  

[Idyllic]

I know this isn't easy to hear but to be honest I would not worry about the multiple Genotypes. It sounds like you are doing what you can which is learn about Hepatitis C and how to treat it.

You are right until you clear the virus no alcohol.

I say as long as you are feeling OK and having no extrahepatic manifestations then you probably are in a position to wait for a tolerable, less harsh treatment. The more you learn, the more you will be able to determine how to proceed :)

http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Extrahepatic.pdf

[QWC]

My liver biopsy revealed (6 years ago) that the fibrosis was a 2-3, but 3 different doctors I have spoken to have told me to wait for the interferon/riba FREE meds because my fiancee failed miserably on that combo of meds, and I also have past emotional issues from an abusive father and am small-framed--They (and I) know that interferon would not cure me, but probably kill me in one way or another.  The good thing is that (in the past 6 years), I have been VERY liver-friendly--NO drinking, what-so-ever, take liver herbs daily, eat very healthy, and on my last full panel bloodwork, my AST and ALT levels dropped about 50 pts each for the first time.

[QWC]

I just know, can-do-man.  I have sort of been in "isolation" since my diagnosis.  I am almost positive that my fiancee has the same multiple gt's as well.  He will get the new test next month.  The test result did also say it could of come from some kind of " cross-nucleic reaction"  (whatever that is), but I know for sure I have not been infected twice.  I am only posting all this personal info to try to find Someone else with the same diagnosis, OR,  for Bluemetal's great new research on the new meds that will cure All the genotypes.  It is not a matter of knowing that I was not infected twice--the matter is again, finding the correct cure, and also finding a person who is in the same boat, because it will require a different or perhaps longer treatment.  Please do not question the facts--that is not my purpose for posting.

[Idyllic]

Sorry I didn't see the bit about milk. Just as a heads up you are bound to come across all kinds of supplements or food ideas that claim to eradicated Hepatitis C. So far that I have seen only treatment with HCV meds works.

[Idyllic]

although they told me six years ago I was just Genotype 1, when I had my biopsy
___________________

What were the results of your biopsy?

In other words what is your stage and grade of liver disease?

Knowing just how advanced your fibrosis is usually a major factor in planing when to treat.

[QWC]

Thank You Bluemetal, I did go to the www.achillion.com, website and it does look Very promising.  Thank You for keeping up on such good info.  This is Ground-breaking!  Have you heard of the other one Daclatasvir?, and do you know if that will be a contender as well?  Of course we have to wait, but I have no problem waiting for them to iron out all the wrinkles, so that any "missed" side effects won't mysteriously pop out of no where.

[bluemetal]

Both your genotypes are most likely to be cured at the same time and I believe your hep doc will agree, due to the fact that the primary is gt1a. Heres how it works- during the various clinical trials involving these new gen antivirals such as ledisprivir, simprivir, daclatasvir, etc, all combined with that single powerhouse-sofosbrivir (Sovaldi), the scientists were all the time were focusing on the gt1a, finding the cure for THIS genotype because it was the most difficult to cure and infected about one-half of those with HCV.During the trials they enrolled all genotypes from 1 thru 4 and the subtypes as well. It was noticed early that the gt 2 thru 4's were reaching SVR early, the virus being wiped out. The anti-virals and protease inhibitors were then modified more and more, kind of "fine-tuned" to fight the gt1a's. They finally acheived this with Gileads wonder drug coming in autumn. And now I personally believe, after extensive study and research, that Achillion has created an even better drug but it wont be ready for market until sometime next year.

[can-do-man]

"I caught it from my then boyfriend, now fiancee, don't do drugs, and have not been around anyone else with hep C."

I'm curious about the part about not being around anyone else with Hep C. How would you know? Besides keep in mind all Heppers are not druggies. Doctor D who is A well known Hepatologist who used to post here had Hep C. Who would have thought?

[QWC]

I was also wondering if anyone read the thread on coconut oil and milk and if anyone thinks it really can help cure hep c?