Aa
New Rash Helper
Well lots of folks know that post treatment I was left with autoimmune skin problems on my leg and hands. Had major 'ribarash' (from the interferon of course) during treatment. The derm prescribed me Fluticozane which seemed to be the only thing to stop the itching.
Yesterday in a fit of scratching I realized I was almost out of it. I didn't want to pay $25 copay and then the copay for the meds so while I was in CVS I decided to try something that was on the shelf.
I swear so far it seems to work as well as the presciption. Cortizone-10 Eczema and Itchy, Dry Skin Med. Orange bottle with white and blue lettering.
Just thought it might help somebody else. Yes surprise I didn't reach for the Gold Bond like always but this one seems to work on the eczema (which I heard on tv is really what the rash is) very very well with the itch and the rash seems to be abating.
For ten bucks it is worth trying.
Yesterday in a fit of scratching I realized I was almost out of it. I didn't want to pay $25 copay and then the copay for the meds so while I was in CVS I decided to try something that was on the shelf.
I swear so far it seems to work as well as the presciption. Cortizone-10 Eczema and Itchy, Dry Skin Med. Orange bottle with white and blue lettering.
Just thought it might help somebody else. Yes surprise I didn't reach for the Gold Bond like always but this one seems to work on the eczema (which I heard on tv is really what the rash is) very very well with the itch and the rash seems to be abating.
For ten bucks it is worth trying.
I am currently on Tx and have a ton of rashes. My family doctor prescribed triamcinolone acetonide cream 0.1%. I brought it to my last doctors appt, and my hep doc "okay'd" it. It's basically a steroid cream. From what I've read so far, even though my doctor gave me the green light, should I stop using the cream?
Back to the Gold Bond for them then!!!!!!!! :)
Damn this stuff is really helping me I wish others on treatment could use it too it's fabulous on the eczema! Day 2 and no itching that is like some miracle!
Damn this stuff is really helping me I wish others on treatment could use it too it's fabulous on the eczema! Day 2 and no itching that is like some miracle!
You already treated and cleared but for someone who still has the virus, streroids are not a good thing...even in oitment because a small amount is absorbed systemically.
Co
Feb 2010
Glucocorticosteroids increase cell entry by hepatitis C virus
Sandra Ciesek, Eike Steinmann, Markus Iken, Michael Ott1, Fabian A. Helfritz, Ilka Wappler, Michael P. Manns, Heiner Wedemeyer and Thomas Pietschmann
Abstract
Background & Aims:
Corticosteroids are used as immunopressants in patients with autoimmune disorders and transplant recipients. However, these drugs worsen hepatitis C virus (HCV) recurrence after liver transplantation, suggesting that they may directly exacerbate HCV infection.
Methods:
The influence of immunosuppressive drugs on HCV replication, assembly and entry was assessed in Huh-7.5 cells and primary human hepatocytes using cell culture- and patient-derived HCV. Replication was quantified by immunofluorescence, luciferase assays, quantitative reverse transcriptase PCR, or core ELISAs. Expression of HCV entry factors was evaluated by cell sorting and immunoblot analyses.
Results:
Glucocorticosteroids slightly reduced HCV RNA-replication, but increased efficiency of HCV entry by up to 10-fold. This was independent of HCV genotype but specific to HCV, because vesicular stomatitis virus glycoprotein-dependent infection was not affected by these drugs. The increase in HCV entry was accompanied by upregulation of mRNA and protein levels of occludin and the scavenger receptor class B type I (SR-BI) - 2 host cell proteins required for HCV infection; increase of entry by glucocorticosteroids was ablated by RU-486, an inhibitor of glucocorticosteroid signaling. Glucocorticosteroids increased propagation of cell culture-derived HCV ca. 5 to 10-fold in partially differentiated human hepatoma cells, and increased infection of primary human hepatocytes by cell culture- and patient-derived HCV.
Conclusions:
Glucocorticosteroides specifically increase HCV entry by upregulating the cell entry factors occluding and SR-BI. Our data suggest that the potential effects of high dose glucocorticosteroids on HCV infection in vivo may be due to increased HCV dissemination.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WFX-4YC1K1P-2&_user=10&_coverDate=02%2F10%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=75d5afc7dd7399536465b046c8672b22
Co
Feb 2010
Glucocorticosteroids increase cell entry by hepatitis C virus
Sandra Ciesek, Eike Steinmann, Markus Iken, Michael Ott1, Fabian A. Helfritz, Ilka Wappler, Michael P. Manns, Heiner Wedemeyer and Thomas Pietschmann
Abstract
Background & Aims:
Corticosteroids are used as immunopressants in patients with autoimmune disorders and transplant recipients. However, these drugs worsen hepatitis C virus (HCV) recurrence after liver transplantation, suggesting that they may directly exacerbate HCV infection.
Methods:
The influence of immunosuppressive drugs on HCV replication, assembly and entry was assessed in Huh-7.5 cells and primary human hepatocytes using cell culture- and patient-derived HCV. Replication was quantified by immunofluorescence, luciferase assays, quantitative reverse transcriptase PCR, or core ELISAs. Expression of HCV entry factors was evaluated by cell sorting and immunoblot analyses.
Results:
Glucocorticosteroids slightly reduced HCV RNA-replication, but increased efficiency of HCV entry by up to 10-fold. This was independent of HCV genotype but specific to HCV, because vesicular stomatitis virus glycoprotein-dependent infection was not affected by these drugs. The increase in HCV entry was accompanied by upregulation of mRNA and protein levels of occludin and the scavenger receptor class B type I (SR-BI) - 2 host cell proteins required for HCV infection; increase of entry by glucocorticosteroids was ablated by RU-486, an inhibitor of glucocorticosteroid signaling. Glucocorticosteroids increased propagation of cell culture-derived HCV ca. 5 to 10-fold in partially differentiated human hepatoma cells, and increased infection of primary human hepatocytes by cell culture- and patient-derived HCV.
Conclusions:
Glucocorticosteroides specifically increase HCV entry by upregulating the cell entry factors occluding and SR-BI. Our data suggest that the potential effects of high dose glucocorticosteroids on HCV infection in vivo may be due to increased HCV dissemination.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WFX-4YC1K1P-2&_user=10&_coverDate=02%2F10%2F2010&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=75d5afc7dd7399536465b046c8672b22
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