New drug Nov-205 drug

[jboyhk]

It says here they were starting clinical trials is Sep 06. Anybody know anything about it? It seems to be already approved in Russia.

NOV-205, Hepatitis

NOV-205 is being developed to treat chronic hepatitis C in the U.S. NOV-205 acts as a hepatoprotective agent with immunomodulating and antiinflammatory properties. The FDA accepted Novelos' Investigational New Drug Application (IND) for NOV-205. The initial U.S.-based Phase 1b trial will evaluate NOV-205 as monotherapy for chronic hepatitis C genotype 1 patients who have failed pegylated interferon plus ribavirin therapy. The trial commenced in September 2006.

NOV-205 is approved for use in the Russian Federation under the trade name Molixan

[Hepatitis Researcher]

It sounded like it was internal in Russia.

[Hepatitis Researcher]

It seems to be a candidate on the antibrotic drug list. But currently, considering the need to inject and the difficulty to get one might think of replenishing the intracellular glutathione levels with NAC, that works without question very well in that effect.
Notwithstanding the above , there might be more to this double glutathione than just the glutathione effect. But since it worked against HBV and HCV - probably by decreasing hepatic injury- it is not very likely to encompass a direct inhibitory effect upon the HCV machinery, but rather an indirect effect - if any- against HCV VL by enhancing immune functions.

[jboyhk]

So what you are saying is that it may be a candidate to replace interferon in combo treatment also?

[Hepatitis Researcher]

If it indeed has an immunomodulatory effect - that remains to be seen- I would doubt it would be of such a strength that it could replace inteferon.

[crsrph]

sounds interesting here are a couple more sites to look at
  
www.tiopoietine.info/Molixengl.htm

Risultati del molixan nella terapia dell'epatite cronica attiva
  this should come up hit translate (unless you read russian ) the text should appear in english the graphs dont seem to transulate
  this chemical seems to be composed of 3 amino acids non essential and ribofuranozil hypoxanthine the amino acids are needed for cytokine formation regulation (modulate immune response)some xanthine drugs seem to inhibit or decrease liver fibrosis ( caffine,pentoxifylline (trental)
the ribofuranozil who knows maybe some structural similarities to riba . will have to watch this trial  

[Tater-ToT]

So You'd "THINK"... But it certainly doesn't appear that way... but hey.. maybe we're not supossed to THINK...

My old Dr Quack, Quack use to get insulted when I'd read something in here & bring it to his attention, or question him on certain things... He took it as a personal assault on his authority, then tell me that we get information quicker on the net than THEY do because it takes them awhile to get the newsletters with studies & read up on them!!! LoL...

I suppose that could be true, but seems to me IF they were truley interrested they would be consistantly on "TOP" of the latest & greatest! I don't get it....

This particular bit of info totally BLINDSIDED me... like it was suddenly pulled out of a hat! Had No Clue!

Well, you're right... leaves lots of questions... but I guess it just gives us something else to look forward to, & watch for.....more competition has got to be a good thing... Right!!!
;)