Aa
A
A
Close
Blank
Avatar universal
Next-Generation (Boceprevir)
from Schering Plough

As part of its long-term commitment to hepatitis C therapy, Schering-Plough also is developing SCH 900518 ("518"), a next-generation HCV protease inhibitor. A Phase IIa study with 518, known as the NEXT-1 study, is currently ongoing. The company said that 518 has been shown to be 10 times more potent in-vitro than other protease inhibitors currently in Phase III development and has the potential for once daily dosing. 518 also has shown decreased emergence of resistance in vitro. Given its pharmacokinetic (PK) profile, the company anticipates that 518 may be active against some HCV strains that are resistant to other protease inhibitors. Phase I proof of concept studies with 518 in treatment-naive patients and those who failed prior treatment, both as monotherapy and in combination with peginterferon (without ribavirin), demonstrated enhanced antiviral activity, with up to 4 log10 and 5 log10 decreases in circulating HCV, respectively.

Full results of the boceprevir HCV SPRINT-1 study and early phase clinical results with SCH 900518 are being submitted for presentation at a future medical meeting.


http://www.natap.org/2008/HCV/121608_01.htm
Cancel
2 Answers
2 Answers
Page 1 of 1
694630 tn?1227714275
Will that be possible if we would like to order or buy potential drug which is undergoing at trial such as Boceprevir, Telaprevir  etc...
Understand me if my questions are too odd ...
Aung
Comment
Cancel
694630 tn?1227714275
Comment
Comment
Submit Comment
233616 tn?1312790796
cool, this will be one to really watch closely won't it.

mb
Comment
Cancel
233616 tn?1312790796
Comment
Comment
Submit Comment
Your Answer
Avatar universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Submit Answer
A
A
Recent Activity
3060903 tn?1398568723
Blank
Nighthawk61 commented on mishymoshymarcy's status
8 hrs ago
3060903 tn?1398568723
Blank
Nighthawk61 I DO NOT KNOW THE WORD FEAR... Comment
20 hrs ago
408795 tn?1324939275
Blank
fretboard uploaded new photos
May 04
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
683231 tn?1438659664
Blank
Auburn, WA
317787 tn?1460223707
Blank
DC
163305 tn?1333672171
Blank
Rural Mural, CA
446474 tn?1446351282
Blank
San Francisco, CA
Avatar universal
Blank
1815939 tn?1377995399
Blank
Hepatitis C Community Resources
RSS Expert Activity
233488 tn?1310696703
Blank
Marathon Running Done Over Many Yea...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
233488 tn?1310696703
Blank
New Article on Multifocal IOL vs &q...
May 21 by John C Hagan III, MD, FACS, FAAOBlank
748543 tn?1443740527
Blank
TMJ/TMJ The Connection Between Teet...
01/15 by Hamidreza Nassery , DMD, FICOI, FAGD, FICCMOBlank
Top Hepatitis Answerers
683231 tn?1438659664
Blank
Auburn, WA
317787 tn?1460223707
Blank
DC
163305 tn?1333672171
Blank
Rural Mural, CA
446474 tn?1446351282
Blank
San Francisco, CA
Avatar universal
Blank
1815939 tn?1377995399
Blank