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163305 tn?1333668571

PCR Positive Abnormal

What does it mean if a viral load test results are positive abnormal?
I know the positive part but what's the abnormal mean?
26 Responses
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163305 tn?1333668571
Thank you so much for your expertise and sharing it with us.
I take your recommendations seriously.
Its wonderful to have someone as knowledgeable as you are, who is willing to take the time to help us out.   Thanks again.              OH
Helpful - 0
Avatar universal
MEDICAL PROFESSIONAL
Re lactulose ; Its daily dose can be reduced to a level where it does not send you to the reading room at improper frequency. Its main function is not to get the bowels working, but to preferentially foster/feed/accelerate growth    of bening, nonpathogenic colonic bacteria, so that the bad ones are heavily outnumbered/antibiotically restrained: "Eubiosis".

Its use in the emergency situation of clinically apparent hepatic encephalopathy is different - you want to clean out the ammonia/+other toxic chemicals producing bacteria as quick as possible to detoxify your brain. In this situation often enemas with up to 200mls are given. A life saving treatment, achieved with a ridiculously cheap and totally harmless substance.
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Avatar universal
MEDICAL PROFESSIONAL
The PPC was not included, because I wanted to keep it to a bare minimum and also OH probably has read all the PPC aspects already. With the NAC there is literally certainty, that it will raise Glutathione levels, extra and inctracellularly. These types of statements you find at numerous websites for numerous things ( on ourpose I did not call them "products"). Its called claims, and in many cases the basis is a well working keyboard.

If you have personal control and have aquired direct hard data regarding the glutathione levels as actually measured with independent assays in independent laboratories( quite difficult to do !)

after supplementation of NAC at proper levels

both in serum as well as in circulating lymohocytes,

and the results are clean and strong

and they fit with the experimental work as published by university/NIH research in peer reviewed journals

and the papers describe the methodology/results  in proper fine detail

and you have enough understanding  of the assays/methods used  to judge them of being proper to the question on hand,

then you can start to draw firm conclusions about expected changes in biological reality in a human patient that can actually be achieved.


Re fishoil : What matters is the content in EPA and DHA only. DHA is slightly more important than EPA. About 800mg total of each/day (in divided doses) is probably close to optimum.. The less remainder oil, the less of any  undesirable contamination you will have.

There are a few labs that can actually measure your ratio of omega 6/3  fatty acids after supplementation as well as the Arachidonic acid to EPA ratio.
Helpful - 0
163322 tn?1458676408
OH:  TOILET ALERT!!  I have to remember that.  Hi, I just checked in---your sense of humor is going strong.  :-)

Luv ya, Maui

Goof: RE: fish oil/cod liver oil:  A friend called my attention to possible high levels of mercury found in fish... you may want to check it out.  I use flax seed oil myself.
Helpful - 0
163305 tn?1333668571
HR: There is a reason not to take lactulose all the time. My bowels work just fine w/o the stuff.
With it, I'm on toilet alert.

I ordered glutamine powder on-line last night. Thanks for the suggestion.
I take a mulitple vitamin w/o iron daily and my own flavinoids from organic orange and lemon peels, heated and mixed with honey.
I buy organic tumeric and cap it up myself. I like to do that because I can use veggie caps which I'd guess are easier for my liver to deal with.
NAC? I think I read about it. I'll do a search and read some more.

Spontaneous bacterial peritonitis ?  I'm an artist and gardener. The only latin I know is pigment colors or plants. However, I can figure out the instant bacteria part.

Maybe my biggest problem or asset is I can't help but still think of myself as healthy. I really don't want to focus my life on illness.

OL: thanks for the kind thoughts. I'll email you soon.
Helpful - 0
92903 tn?1309904711
I noted with interest that PPC was not included in your post. Also, do you have a preference of Fish Oil over Cod Liver Oil? Can the added Vit A in COL be a burden to an ailing liver?

Thanks, as always,
Helpful - 0
Avatar universal
Dear One,
You have been in my heart.  I see you gracefully, gratefully and graciously dealing with whatever has been dealt to you.  Your heart and humor, your intellegence and world view will help you make the right decisions.  Good advice from HR re supplements.  I agree about the endoscopy.  Not a difficult proceedure and you will know much more about your condition.  Banding can really help.  Some docs also suggest perscription meds to lower the hypertinson.  

How is your body feeling since ending treatment?  

I am still on TX going for 72 weeks. last shot Jan 11.  Been on and off 270 peg.  Now just maintaining on SOC.  I have been back to work  since summer.   Currently have a bad cold and wanting to sleep sleep sleep.  

I am so glad for the afternoon we shared.  I see you shinning brightly.

Love, Oceanliver
Helpful - 0
Avatar universal
MEDICAL PROFESSIONAL
We all have "leaky "guts. The question is how leaky and what liver waits behind the "leaks" .
Inulin is very important to add.  Thre is no reason not to take the lactulose all the time. It is not a last resort medicine, it is a great prebiotic.

It is important to understand the different types of intestinal flora and how you can influence the prevalence of the nonpathogenic kind..

Glutamine powder is not expensive. It is well researched, that it specifically helps maintain intestinal epithelial health/integrity.

Do you know what spontaneous bacterial peritonitis is?

NAC plus equal amounts of Vit C are also missing from your formula. How much curcumin is in your tumeric?

Re the endoscopy/banding : If you dont need it, he will not do it. If you do need it: Bleeding from esophageal varices is one of the scariest and deadliest complications of cirrhotic portal hypertension.
Helpful - 0
163305 tn?1333668571
Thanks for the informative reply.
I haven't been taking lactulose for months.

I eat very little meat. I don't have a leaky gut, as far as I know! I eat small meals, focusing on high complex carbs, fresh organic veggies, fruit and some yogurt. If I get canker sores, I take acidopholus.

I'm taking omega 3 fish oil, milk thistle, ALA, gotu kola, SAM-E, tumeric and bromelain.

Do you think I should still take Glutamine? I'll do most anything to help aid my liver.

The endoscopy doesn't scare me, the banding idea does. It hurts my throat thinking about it.
I know, I'm silly and should get over it.
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Avatar universal
MEDICAL PROFESSIONAL
Yes, unfortunately you do fit the defintion of decomp cirrhosis. I would add Inulin to the daily lactulose ( another prebiotic ( branched Fructooligosacharide chain that has been well researched and found slightly superior to FOS)). Cheap - you get it at Trader Joes. Furthermore a heaping teaspoon of Glutamine a day is advisable for intestinal epithelium integrity and will lessen the leaky gut syndrome that contributes to the intestinal toxicity burden of the poor remaining liver. Do you have a probiotic in place? Many small meals, well distributed over the day, with a decent but not excessive amount of lean protein mixed with mainly veggies and some fruits are necessary to not overburden the liver with excessive nutrient influx at any point in time.

Do you have any liver protective supplements in regular use?

Do the endoscopy with your properly advising hepatologist - what is the problem? It is an easy procedure and it will confirm if the "weaning off propranolol" was a good idea.
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163305 tn?1333668571
Lets see,how do I know?  There was the ascites which is why I first saw a doctor about my 'condition.' I looked pregnant but was still swimming daily and climbing up mountains, doing pilates, etc.
I was diagnosed with HCV and cirrhosis ( Sept. 2005, in Bangkok) I got rid of the ascites with diuretics and maintain a low salt diet. The ultrasound showed scarring. I've been on propanlol thoguh weaned myself off of it. My heptoligist really wants to do an endoscopy.
   I had encephalopathy but got rid of that with lactulose.

I'm careful about what I eat, am taking supplements and feel I'm doing well, all things considered.
Last time my MELD score was 12. My heptologist would like to get me on a transplant list but I don't have insurance and I'm squeamish about invasive techniques.
Got any ideas?
Helpful - 0
276730 tn?1327962946
Damn.Im soooo sorry to hear this. I feel your heart.
Take care of yourself. There will be another option for you.
Warm Peaceful Thoughts
Charm
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Avatar universal
MEDICAL PROFESSIONAL
Orphaned..
" I know I have decompensated cirrhosis "

How do you know that?
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Avatar universal
So sorry to hear this, OH. My heart goes out to you.
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163305 tn?1333668571
I just got an e-mail from my doc. He confirmed: The "abnormal" is due to the fact that "normally" this test will be "negative" if you do not have measurable virus in the bloodstream. It doesn't mean anything more than that.

He too suggested another test to be sure, this time a PCR not just a TMA.
He also mentioned a study that I may be able to get into but I can't think about that right now.

I'm not discouraged just annoyed. I know I have decompensated cirrhosis which complicates treatment.

Thanks to everyone here. I honestly couldn't have kept any degree of sanity during tx if it weren't for all of you.                             OH
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Avatar universal
Dear OH,  

I'm so - so so ... sorry.  Please don't get discouraged!

... I love your pastel and your view ... you are very artistic.

All the best, always
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173930 tn?1196338398
Sorry to hear that is positive....but please take anothe test..thats what I would do
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Avatar universal
Damn, will you get another follow up test just to make sure. I am so sorry to hear. This is not looking good at all as a whole, the list just keeps getting longer. Take care!

jasper
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Avatar universal
Normal range = Undetected

Abnormal range= Detected aka "positive"
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163305 tn?1333668571
Sure, I know its positive, disappointing but not unexpected. I'm just still wondering about the abnormal but maybe mremeet is right. However  my other reports never said either normal or abnormal.   Thanks all. Goodnight Gracie.
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Avatar universal
Just keep breathing, okay?   Can't help but think of your most beautiful poem you sent me.   Earthquake alright.  S'pose somehow you knew didn't you?  Just read it again and yup, you knew.  
Sleep sweet Orphanedhawk.  It's just another battle.  And you know battle, don't you.  
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92903 tn?1309904711
Concur with meet - postitive result - and the lab gives a helpful Abnormal for them that need the help. Assume this is was yours OH. I am very sorry.
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Avatar universal
I'm pretty sure a positive HCV RNA test is called "abnormal" simply to indicate that it's abnormal for a healthy person to test positive. If you were negative for HCV RNA, the test would come back "normal" indicating that everything's ok. I suspect "abnormal" is just a quick way to tell a doctor (who may not be a GI or hepatologist) that something's not right, and the thing that's not right is the presence of the HCV virus.
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163305 tn?1333668571
The report says specimens that are detected are reported as"Positive". Specimens in which no HCV RnA is detected are reported"Not Detected."  
So, the question is why Positive Abnormal?

Wyn: I will let you guys know once I find out.
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