I bet you guys are sick of me asking questions about Procrit and anemia, but here goes: husband Geno 3, week 16/24. 4 & 12wk PCR UND. Beginning hgb was 13.3. After 5 weeks of tx hgb was 7.4. Riba was stopped for 3 weeks. During that time he was started on weekly Procrit of 40,000IU. When his hgb got back up to 11.6 he was started back on his full 1000mg Riba dose. Since that time his hgb has dropped about 1/2 point per week. It leveled off at 9.0 for the last 2-3 weeks. His doc wanted him to double up on the Procrit, doing two shots per week of 40,000IU. Husband resisted this at first because he's sick of injecting himself (he's just sick of the whole thing, period). He asked about a one pill Riba reduction instead. Doc said one pill wouldn't make a difference and if they were to reduce it should be to 600mg/day. Bottom line is, I think they butted heads (I wasn't there, 1st appt I missed) and the doc told him to "do whatever he wanted" and walked out of the room. This is just par for the course with this doc. Every time we go in he never knows what the Riba dose is or anything else. He has the chart right there in front of him and he wrote the Rx...shouldn't he know that??!! Anyway, after talking it through husband and I decided he would go ahead with the double dose of Procrit and a one pill Riba reduction. This week he did Procrit on Mon/Thurs and reduced the Riba beginning Tuesday. Yesterday's lab work shows his hgb at 8.0. My question is, will the increase in Procrit still take 2-3 weeks to work even though he's already been taking it for two months?