I want to thank all of you for the information on this forum. I am now on my 3rd week of the triple therapy. The pegasys injections do cause me to run a fever and ache etx. After about the first week i broke out in the horrible rash everyone warns about, but my GI was able to control it almost immediately. Other than that, so far so good. Just the run of the mill nausea etx that seems to be pretty common in everyone's posts. The only suggestion i have for anyone is to most definately speak with your GI about everything. My initial appointment was with my GI's Nurse Practitioner and she was of no use. She could not answer any questions and referred me to the internet and home nurse to answer all my questions. Once i was able to get an appt w. the actual GI everything changed. He was shocked to know how his NP was treating his patients etx. I have the hydroxyzine for the rash but the lotion he rx,d was the best it is triamcinolon .1%. Also for over the counter nausea, the pharmacist gave me what they call "coca cola" syrup (dextrose/levulose) mixture. It works very well. Again, thanks for all the good information here and I wish all here good luck. I go on the 14th for labs and the 17th for the first batch of results. I am hoping for the best. Thanks again to all.