SVR After 8 years?

[Upbeat]

Anyone know of anyone who is still clear after 8 years? I read somewhere that everyone relapses after 8 years. It sounded strange to me.

                                                         Ron

[Twinmick]

I am clear sinse 1998. Former 3 A , mono 6 mnd -relapsed and then 1 year combo.

[desrt]

There are people who are still SVR after clearing with Intron A monotherapy back in the early 90s.

[susan400]

Considering that I've never even gotten an SVR, I'd be HAPPY just to have it for 6 mon., much less for 9 yrs!    If somebody could be SVR for 5 yrs., even that would be 5 yrs of giving your liver a break, 5 yrs of moving on with your life and not having to worry about this virus.  5 yrs of putting liver cancer and liver failure on the back burner for those 5 yrs.  I think that worrying about staying SVR past 9 yrs is that someone (a low number) has relapsed after all that time, is looking at the glass as being 1/2 empty, instead of looking at the glass as being 1/2 FULL.   I could not have treated all these times if I thought that way.     Being on treatment, you feel depressed enough, without thinking of that kind of possibility.     Anyway.......

Susan

[jmjm530]

That's wrong. In fact, some recent studies showing the durability of SVR at least ten years out, some perhaps even more.

-- Jim

[nygirl7]

It sounds as brilliant to me as "all skinny people clear the virus and have SVR".

Or "go ahead and use my needle it hasn't been used since yesterday so any disease would be dead"

Or "the check is in the mail"

[mremeet]

Sorry, didn't mean to be overly sarcastic towards you. But you've been around here long enough to know that "everyone [SVR] relapses after 8 years" is not a true statement. And no, I can't think of anyone I personally know that has SVR-ed for longer than 8 years. However, I have encountered several people over the years on the net that have maintained an SVR status via both natural and drug induced clearance for 8 years or more. Plus, obviously it's well documented within the scientific community that an SVR status is extremely durable, and the long term (i.e. 8+ year) SVR population is getting larger all the time. I've never seen anything substantial that has proven or suggested an SVR status will evaporate or weaken or falter after any length of time yet measured/observed (which certainly includes a length of time greater than 8 years).

What is your source that "everyone [SVR] relapses after 8 years"? Who's claiming this is true?

[Tallahassee]

Interesting studies...

Is it possible that "relapsers" were just re-infected?
It would be nice to know if these relapsers' genotype was re-tested.
I personally think that "my" virus came from the dental office...

All the best!  Stay positive!

[orleans]

"natural" svr Hey, How 'bout a little info on that.  thanks, jm

[mikesimon]

I don't know them but here is the link:http://www.natap.org/2004/HCV/083004_06.htm

Researchers at the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland conducted a follow-up study of 10 patients with chronic hepatitis C who were treated with interferon-alpha-2b for 52 weeks (+/- 6 weeks).

The follow-up period ranged from 6 to 13 years, and liver biopsies were done 5 to 11 years after initiation of therapy.

Among the 5 patients who had an SVR, all remained HCV RNA negative, 4 had normal aminotransferase levels and 1had minimally elevated aminotransferase levels.

Another study, conducted at the Consiglio Nazionale delle Ricerche in Palermo, Italy, followed a group of sustained responders for up to 109 months after the completion of interferon therapy.

At the end of the follow-up period, 56 out of 62 sustained responders (90.3%) were serum HCV RNA negative.

1999

[jmjm530]

NY: It sounds as brilliant to me as "all skinny people clear the virus and have SVR".
-----------
You haven't heard of SVR (Skinnygirl Viral Response)? C'mon :)

But seriously, low BMI is a positive predictor of SVR but no guarantee.

-- Jim

[Upbeat]

I never stated I believed the statement I only asked about it.  I read it on one of the natural cure sites like a lloyd wright site.  The info sometimes is long in comming and I like to keep an open mind.  

                                                                                                       Ron

[returntosender]

I posted a link to a study a while back that followed SVRs for as long as 18 years.  There were very few if any relapses.  Something like 2 out of 400.   There was also little evidence of residual virus in the organs as well.  Pretty optimistic look at SVR.   Here is a link to a few studies I found, not necessarily to large one, although if I find it I will post it.  

http://www.natap.org/2003/Jan/010803_1.htm

[Jordie59]

I have a friend geno 1. SVR 9 years. Was not even able to complete full treatment due to severe depression and anemia. So far so good.

[Upbeat]

Do you personally know anyone who has been clear of the virus for more than 8 years?

                                                                                                        Ron

[mremeet]

I heard there's a leprechaun and a pot of gold at the end of every rainbow.

[GrandOak]

I haven't heard of this relapse concern.  

Personally, I'd settle for UND and everything after that would be gravy.