Aa
A
A
Close
Avatar universal
Steatohepatitis
My wife (48 yrs old, white, 5'4", 190 lbs, non-drinker, non-smoker, no drug use) recently had a liver biopsy with the following results. Could you please tell me lay-men's terms what this means and what my wife has to look forward to; prognosis and treatment.  Thank you very much.

Sections reveal three disrupted needle biopsy core fragments of distorted, chronically inflamed hepatic tissue. Moderate fatty change is noted thoughout. Most portal triads are expanded by mixed chronic inflammatory cells and scattered neutrophils, the latter associated with proliferating bile ducts. Small number of eosinophils are also included in the infiltrate. Trichrome stain reveals moderate to severe portal fibrosis with focal portal-central and portal-portal bridging (stage 3 in a recently proposed four part staging scheme for steatohepatitis). Inflammatory infiltrates spill into the lobules where they are associated with occasional necrotic hepatocytes and ballooning degeneration of hepatocytes. The overall appearances are those of active steatohepatitis. They suggest a differential diagnosis including nonalcoholic steatohepatitis, alcoholic hepatitis,k and ascending cholangitis.

Microscopic Diagnosis:  Steatohepatitis with moderate to severe portal fibrosis.
Cancel
3 Answers
Page 1 of 1
Avatar universal
I'm not a doctor, but it sounds like your wife has nonalcoholic steatohepatitis (NASH), the most common form of nonalcoholic fatty liver disease.  It is an inflammation of the liver due to the accumulation of fat. NASH may lead to cirrhosis
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Avatar universal
Hre is a link that might help. You must register at www.medscape.com to view but it is free to do so and the information is well worth it.

<A HREF="http://www.medscape.com/viewarticle/497001?src=mp/">FATTY LIVER</A>
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Avatar universal
The following site really helped me when I first started this journey.  Sorry I don't know how to make a link.  You'll just have to copy and paste.

http://www.rnceus.com/course_frame.asp?exam_id=19&directory=lf

God Bless,

Pattie
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Your Answer
Avatar universal
Answer
Do you know how to answer? Tap here to leave your answer...
Answer
Answer
Post Answer
A
A
Explore More In Our Hep C Learning Center
image description
What Is Hepatitis C?
Learn about this treatable virus.
image description
Diagnosing Hepatitis C
Getting tested for this viral infection.
image description
Just Diagnosed? Here’s What’s Next
3 key steps to getting on treatment.
image description
Understanding Hepatitis C Treatment
4 steps to getting on therapy.
image description
Your Guide to Hep C Treatments
What you need to know about Hep C drugs.
image description
Managing Side Effects of Treatment
How the drugs might affect you.
image description
Making Hep C Treatment a Success
These tips may up your chances of a cure.
Recent Activity
406584 tn?1399591666
Blank
10356 commented on stilltrying1965's status
Jan 19
317787 tn?1473362051
Blank
Dee1956 MEEGY 219 DAYS!! Comment
Jan 17
406584 tn?1399591666
Blank
10356 commented on WalkTall's status
Jan 15
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
317787 tn?1473362051
Blank
DC
163305 tn?1333672171
Blank
Rural Mural, CA
446474 tn?1446351282
Blank
San Francisco, CA
Avatar universal
Blank
1747881 tn?1358189534
Blank
Greeley, CO
2059648 tn?1439770265
Blank
Hepatitis C Community Resources