High Sgpt

[danial99]

I underwent a treatment of interferon for Hepatitis C for six months and it became negative.Recently I had another PCR test which says that C virus is non reactive but my SGPT is constantly high between 57 and 70.What can be the cause and what should I do.I also feel weak and nausea

[danial99]

Thank you very much for the reply sir

[can-do-man]

Forum-M.D.-DT

Apr 09, 2002



Thank you for visiting the family practice forum.

Liver Function Testing (LFTs) is a blood test used to evaluate various functions of the liver, as metabolism, storage, filtration, and excertion. Certain conditions, medication or alcohol may affect the "function"of the liver and will be demonstrated as abnormalities in certain parameters measured with this test. Some common parameters included with LFTs include alkaline phosphatase(AP), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), and Gammaglutamyl Aminotransferase (GGT). Gallbladder disease commonly causes elevations in AP, however may cause elevations in other LFTs as well. Conditions commonly associated with abnormalities of LFTs include gallbladder disease, hepatitis, fatty liver, cirrhosis, infectious mononucleosis and alcoholism. Certain medications may cause liver inflammation, and therefore, while patients are on these medications the doctor will intermittently order LFTs to determine if these medications are adversely affecting the liver. Some of the medications which may cause inflammation of the liver include 1)cholesterol lowering agents 2) antibiotics or antifungal agents 3) anti-hypertensive medication 4)siezure medication 5) Acetominophen (Tylenol) 6) Anti-inflammatory agents (Motrin).

You are on no medication and I highly doubt that one glass of wine is going to lead to liver problems in and of itself. My two thoughts are this. 1) You need to have a blood test to see if you have any evidence of hepatitis.(a, B, or C) 2) If the blood test for hepatitis is negative, you need to consider the possibility of a "common bile duct stone". While stones in the gallbladder can cause inflammation, so too can stones in the main duct through which bile emptys from the liver. (the common bile duct). There is a test called an "ERCP" which is done by a gastroenterologist, which will help determine if there is the presence of a stone in the common bile duct.

If you are unhappy with the answers you are getting from your regular doctor, it may be time to ask for a referral to a gastroenterologist.

I hope this proves helpful!

Dean M. Tomasello, M.D.


http://www.medhelp.org/posts/Family---Internal-Medicine/Elevated-SGOT-and-SGPT-levels/show/227438