Aa
What is sort term/long term interfon?
Trying to digest all the great info from HR and others. I am a bit confused on the interferon topic. HR mentioned long term/short term interferon. Maybe this is common knowledge, but I haven't heard that term before. Also, I relapsed on both Pegasus and Pegintron, does that mean the virus may be resistant to both? If so, what alternative peg is available? Still not sure what "concensus" peg is either, but I used to know. My ammonia is elevated and having trouble thinking clearly. Thanks.
hahahaha. now there is an idea i can use in the icu! where can i get one? a subdued patient is a good patient ;)
Just trying to add some humor as I'm sure you understand. In actuality, I think the kid was trying to get thrown out as some sort of publicity stunt, and the taser was just a bonus. You know, I've had a few bouts of paroxysmal afib. I wonder if I should try jump starting myself with one of those tasers instead of making the trip to the ER :)
-- Jim
-- Jim
MEDICAL PROFESSIONAL
Thanks for the uplifting sory, Its comforting to think that reality and our perception of it - the truth- is something calm, stable and untouchable by angry, arrogant or temporarily powerful people.
On the other hand, the number of beheaded messengers truthfully reporting the lost battle to the king is substantial.
Had almost exactly the same experience in engineering school ( that I finished before studying medicine) During the final, written exam , lasting a full agonizing week, a diesel motor had to be calculated/designed starting from thermodynamics via numerous corrective factors to the final shop drawings.
Several students had the same task, but being triple careful I found that the original curriculum to be followed contained a very substantial error. Stopped the thing, asked what to do now -and what about the others...This was offcial, government supervised stuff, so the prof got almost teary eyed, so I was "allowed" to proceed according to reality, the others to produce a bull motor.
On the other hand, the number of beheaded messengers truthfully reporting the lost battle to the king is substantial.
Had almost exactly the same experience in engineering school ( that I finished before studying medicine) During the final, written exam , lasting a full agonizing week, a diesel motor had to be calculated/designed starting from thermodynamics via numerous corrective factors to the final shop drawings.
Several students had the same task, but being triple careful I found that the original curriculum to be followed contained a very substantial error. Stopped the thing, asked what to do now -and what about the others...This was offcial, government supervised stuff, so the prof got almost teary eyed, so I was "allowed" to proceed according to reality, the others to produce a bull motor.
MEDICAL PROFESSIONAL
Thanks for the movie. I get the feeling this gentleman acted under the impression the constitution will protect him....
No, I would never wrestle with policemen, I would rather ask them, if they or their relatives had liver or heart problems, so we can together focus on the enemy within...
No, I would never wrestle with policemen, I would rather ask them, if they or their relatives had liver or heart problems, so we can together focus on the enemy within...
The conclusion of 1 study on this stated,
"Both peginterferon alfa-2a [Pegasys] / ribavirin and peginterferon alfa-2b [PegIntron] / ribavirin regimens were similar in efficacy and safety in chronic HCV genotype 3 patients."
Well, that may be so, but although I relapsed on both, the pegasys did a much better job of knocking down my VL and i am going with it next tx.
"Both peginterferon alfa-2a [Pegasys] / ribavirin and peginterferon alfa-2b [PegIntron] / ribavirin regimens were similar in efficacy and safety in chronic HCV genotype 3 patients."
Well, that may be so, but although I relapsed on both, the pegasys did a much better job of knocking down my VL and i am going with it next tx.
You know I'm not the smartest even though I try. Reading this...it would make me wonder why we all didn't do pegasys, with such a higher percentage rate but from what we've all surmised PegIntron was stronger? Now i'm very confused.
Intron A (unbound Interferon2b) 12 hours = short term Interferon
Pegintron ( Non branched chain Polyethylenglycol bound Interferon2b) :% of maximum plsma level still present after 1 week : 9%
Pegasys ( branched chain Polyethylenglycol bound Interferon 2a) 40% plasma level after one week.
Intron A (unbound Interferon2b) 12 hours = short term Interferon
Pegintron ( Non branched chain Polyethylenglycol bound Interferon2b) :% of maximum plsma level still present after 1 week : 9%
Pegasys ( branched chain Polyethylenglycol bound Interferon 2a) 40% plasma level after one week.
HR: Since forceful removal from the premises..
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Actually, I think the whole incident was caught on tape. Didn't realize you were so young though.
http://www.youtube.com/watch?v=6bVa6jn4rpE
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Actually, I think the whole incident was caught on tape. Didn't realize you were so young though.
http://www.youtube.com/watch?v=6bVa6jn4rpE
Great story about such a large number of highly educated people blindly "towing the line" for fear of looking silly! I've seen the same thing over and over in academia (when I was in academia a long time ago). And I remember even myself a little shaky in my understanding of a few things being presented in the classroom keeping my mouth shut when I would have been much better off by speaking my mind and confronting the perceived error. Human beings do not like to reveal their ignorance, or even possible ignorance, especially in front of a large cohort of their peers!
I remember a complicated homework problem one of my professors gave our class and he had been giving it to his students for years. The detailed solution to the problem was posted in the library for all to see/examine/check after the problem had been graded and returned. My solution was marked as incorrect, but I was certain it was right. After looking at the "solution" in the library and working it over and over it became clear my professor's solution was flawed because halfway through a long derivation a fairly simple math error was made (natural log (ln) related). After the math error was made, the remaining content and final result turned out totally wrong. And yet no one had bothered to simply work through the problem themselves in a careful manner and be bold enough to confront the prof about it (he was this haughty intimidating brilliant Scot who'd always write "rrrubbbish!" in blood red ink on any problems you'd get wrong). He was embarrassed I caught him on it, and that it had been "out there" for several years in its incorrect form. But he hired me as an assistant shortly thereafter, so it was a win win I think in the long run.
Also, and this may seem an odd question, but I just have to ask: At the AASLD conference, do they (1) serve alcohol? and (2) serve pate or just good ole' fried liver? Can't help but wonder, that. ;-)
I remember a complicated homework problem one of my professors gave our class and he had been giving it to his students for years. The detailed solution to the problem was posted in the library for all to see/examine/check after the problem had been graded and returned. My solution was marked as incorrect, but I was certain it was right. After looking at the "solution" in the library and working it over and over it became clear my professor's solution was flawed because halfway through a long derivation a fairly simple math error was made (natural log (ln) related). After the math error was made, the remaining content and final result turned out totally wrong. And yet no one had bothered to simply work through the problem themselves in a careful manner and be bold enough to confront the prof about it (he was this haughty intimidating brilliant Scot who'd always write "rrrubbbish!" in blood red ink on any problems you'd get wrong). He was embarrassed I caught him on it, and that it had been "out there" for several years in its incorrect form. But he hired me as an assistant shortly thereafter, so it was a win win I think in the long run.
Also, and this may seem an odd question, but I just have to ask: At the AASLD conference, do they (1) serve alcohol? and (2) serve pate or just good ole' fried liver? Can't help but wonder, that. ;-)
MEDICAL PROFESSIONAL
Yes it is -in its intense form- called induction treatment. It is PPC not PPD, but you will probably need to goto these german hepatologists that conducted the PPC trial in HCV, to receive it as part of your regimen. It seems to positively contribute to SVR - consider the trial specifics - Numbers of patients, overall quality, % SVR difference but it is old and forgotten now. And you must not expect too much from it. Since it porotects the liver, most practitioners would likely advise NOT to take it, since it might protect the hepatocytes too much from the killing effects of the immune system - the same ideas underlying the "antiSilymarin" attitude during tx. I certainly would not dare to say that the emporer is naked when 10000 fans beside me are shouting how beautiful his new clothes are...
I had a related experience at one of this years AASLDs satellite meetings : Challenges in HBV treatment: Dr. Norah T presented a patient that was clearly e-Antigen positive with a viral load probably in the multibillions and stating all the serological facts clearly in his initial labs sheet shown - as e-Antigen negative, by mistake . There is quite a difference how to handle these tow types. So the panel consisting of Drs A, P and G and D did not notice this critical difference in recognizing the patients situation. Nor did anyone in the 500docs auditorium protest in any way. I stood up and first waived my folder like when you want to stop a plane, but to no avail. In fairness, Dr. A from Boston noted that the patients VLs seemed to be somewhat inconsistent with an eAg negative patient. So they went on making first round treatment suggestions, the auditorium voted repeatedly using the voting machines (quite an eye opener, these voting results, really), the panel gave its comments as we progressed through his treatment history, that showed the e-Antigen disappearing and e-Antibody to appear - again not really bothering anyone. I made a last attempt by standing up and literally shouting " This is an eAntigen positive patient, please", which turned all the heads within a 12 foot radius towards me, but did not reach the podium and I started to get glances of warningly raised eyebrows.Since forceful removal from the premises was not what I paid for, I then gave up and retreated to sadly shaking my head. ....
I had a related experience at one of this years AASLDs satellite meetings : Challenges in HBV treatment: Dr. Norah T presented a patient that was clearly e-Antigen positive with a viral load probably in the multibillions and stating all the serological facts clearly in his initial labs sheet shown - as e-Antigen negative, by mistake . There is quite a difference how to handle these tow types. So the panel consisting of Drs A, P and G and D did not notice this critical difference in recognizing the patients situation. Nor did anyone in the 500docs auditorium protest in any way. I stood up and first waived my folder like when you want to stop a plane, but to no avail. In fairness, Dr. A from Boston noted that the patients VLs seemed to be somewhat inconsistent with an eAg negative patient. So they went on making first round treatment suggestions, the auditorium voted repeatedly using the voting machines (quite an eye opener, these voting results, really), the panel gave its comments as we progressed through his treatment history, that showed the e-Antigen disappearing and e-Antibody to appear - again not really bothering anyone. I made a last attempt by standing up and literally shouting " This is an eAntigen positive patient, please", which turned all the heads within a 12 foot radius towards me, but did not reach the podium and I started to get glances of warningly raised eyebrows.Since forceful removal from the premises was not what I paid for, I then gave up and retreated to sadly shaking my head. ....
Ah, I see. so when you said to treat short term and long term, you meant tx with Intron A and perhaps Pegasus as a part of a simulstart? Along with an Antiviral and PPD possibly?
MEDICAL PROFESSIONAL
One injection of the following drugs will last - have a plasma level- in the following fashion:
Intron A (unbound Interferon2b) 12 hours = short term Interferon
Pegintron ( Non branched chain Polyethylenglycol bound Interferon2b) :% of maximum plsma level still present after 1 week : 9%
Pegasys ( branched chain Polyethylenglycol bound Interferon 2a) 40% plasma level after one week.
Note that the Interferon effects last long beyond the existence of a measurable IFN level itself : It initiates a cascade of immunostimulatory events that ripples right from your innate to your adaptive immune system. But it is better to have IFN itself also present all the times : Some effects of the IFN fade of quickly. Several hundred gene product expression intensities are altered in the liver after IFN engages its various receptors. Noone knows or understands all the detailed pathways.
Intron A (unbound Interferon2b) 12 hours = short term Interferon
Pegintron ( Non branched chain Polyethylenglycol bound Interferon2b) :% of maximum plsma level still present after 1 week : 9%
Pegasys ( branched chain Polyethylenglycol bound Interferon 2a) 40% plasma level after one week.
Note that the Interferon effects last long beyond the existence of a measurable IFN level itself : It initiates a cascade of immunostimulatory events that ripples right from your innate to your adaptive immune system. But it is better to have IFN itself also present all the times : Some effects of the IFN fade of quickly. Several hundred gene product expression intensities are altered in the liver after IFN engages its various receptors. Noone knows or understands all the detailed pathways.
Yes indeed. Sometimes I just feel like shouting "OK, OK, JUST TELL ME WHAT TO DO!!!" LOL
I know what you mean, sometimes I read what HR and Jim and Meet are all writing back and forth and I try to figure out if it's even ENGLISH cause it is so far over my head. After all this time I still need a map or keycode or some decoder ring to even attempt what they are all saying!
Thanks Deb, It is a start. So much incredible info from HR and I am trying to get a handle on it. A little foggy lately.
I just don't know the answer but I think at first there was regular interferon and then they came up with Peg-interferon which is the long time version. Consensus interferon is Infergen which is not a peg-interferon but a daily shot.
I hope that helped I thought one of the brainiacs would answer you...but I tried!
I hope that helped I thought one of the brainiacs would answer you...but I tried!
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