Hepatitis C Community
paternal use of Ribavirin
About This Community:

This forum is for questions about medical issues and research aspects of Hepatitis C such as, questions about being newly diagnosed, questions about current treatments, information and participation in discussions about research studies and clinical trials related to Hepatitis. If you would like to communicate with other people who have been touched by Hepatitis, please visit our new Hepatitis Social/Living with Hepatitis forum

Font Size:
A
A
A
Background:
Blank
Blank
Blank
Blank Blank

paternal use of Ribavirin

Does anyone know of an actual case of pregnancy and the father is using Ribavirin
Ribavirin-interferon-alfa-2a during conception? Need to know the outcome. Tnx
Related Discussions
10 Comments Post a Comment
Blank
475300_tn?1312426726
Hi I can't answer your question but the doctors told me not to even let a pregnant person TOUCH the riba.

Denise
Blank
1117750_tn?1307390169
yes i do , and you dont want to know the outcome,
Blank
971268_tn?1253204399
In my husband's trial were we made to sign a consent agreeing to use 2 forms of birth control throughout the duration of the trial and for six months afterward. They are serious about this, because ribavirin causes birth defects.
Blank
1233973_tn?1267738704
******This in no way indicates that I think it is in anyway wise to try and conceive while either partner is on ribavirin. It is a profoundle BAD idea.   It is only professional experience*******


Yes and the baby is healthy and beautiful.  With regards to ribavrin and sperm, in some respects, the jury is still out.  Ribavirin can cause changes in the actual structure of the sperm.  The drug is also found in semen.  It is unsure whether or not the drug is present within the sperm cell or not.  There is a registry of paternal ribavirin pregnancies carried to term and there have been results of successful presnancies.  
Blank
Avatar_f_tn
I'd really love more help on this area. I have 4 months left of treatment (I'm a 30 yr old male) and my wife and I want to have kids soon. We will wait the 6 months to be safe, but I'd love to get some help or examples of other paternal experiences. Has anyone had a bad or good result from pregnancy?  First hand experience?
Blank
Avatar_f_tn
I just found out I am pregnant and my boyfriend only has one month left of ribovarin/pegintron treatment. I want the baby but Im am terrified. can you explain a little more to me about this? Did you get someone pregnant on treatment? I see it says the baby is healthy but it doesnt say whether it was yours and if the father was on treatment or the mother? Please help me to understand. Lindsay.
Blank
Avatar_f_tn
Please, I need to know the outcome. I just found out I'm pregnant and my boyfriend is on his last month of ribovarin/pegetron treatment.
Blank
Avatar_f_tn
Here is the information from the package insert for Ribavirin:

Warnings and Precautions
Pregnancy

Ribavirin Capsules may cause birth defects and death of the unborn child. Ribavirin therapy should not be started until a report of a negative pregnancy test has been obtained immediately prior to planned initiation of therapy. Patients should use at least two forms of contraception and have monthly pregnancy tests during treatment and during the 6-month period after treatment has been stopped. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. Ribavirin has demonstrated significant teratogenic and embryocidal effects in all animal species in which adequate studies have been conducted. These effects occurred at doses as low as one twentieth of the recommended human dose of ribavirin. Ribavirin therapy should not be started until a report of a negative pregnancy test has been obtained immediately prior to planned initiation of therapy [see BOXED WARNING, CONTRAINDICATIONS (4), USE IN SPECIFIC POPULATIONS (8.1), and PATIENT COUNSELING INFORMATION (17.2)].

USE IN SPECIFIC POPULATIONS
Pregnancy
Pregnancy Category X

[See CONTRAINDICATIONS (4), WARNINGS AND PRECAUTIONS (5.1), and NONCLINICAL TOXICOLOGY (13.1)].
Treatment and Posttreatment
Potential Risk to the Fetus

Ribavirin is known to accumulate in intracellular components from where it is cleared very slowly. It is not known whether ribavirin contained in sperm will exert a potential teratogenic effect upon fertilization of the ova. In a study in rats, it was concluded that dominant lethality was not induced by ribavirin at doses up to 200 mg/kg for 5 days (estimated human equivalent doses of 7.14 to 28.6 mg/kg, based on body surface area adjustment for a 60 kg adult; up to 1.7 times the maximum recommended human dose of ribavirin). However, because of the potential human teratogenic effects of ribavirin, male patients should be advised to take every precaution to avoid risk of pregnancy for their female partners.

Women of childbearing potential should not receive ribavirin unless they are using effective contraception (two reliable forms) during the therapy period. In addition, effective contraception should be utilized for 6 months post-therapy based on a multiple-dose half-life (t1/2) of ribavirin of 12 days.

Male patients and their female partners must practice effective contraception (two reliable forms) during treatment with ribavirin and for the 6 months post-therapy period (e.g., 15 half-lives for ribavirin clearance from the body).

A Ribavirin Pregnancy Registry has been established to monitor maternal-fetal outcomes of pregnancies in female patients and female partners of male patients exposed to ribavirin during treatment and for 6 months following cessation of treatment. Physicians and patients are encouraged to report such cases by calling 1-800-593-2214.

Ribavirin may cause Birth Defects or Death of your unborn baby. Do Not Take Ribavirin if you or your sexual partner is pregnant, or plan to become pregnant. Do Not become Pregnant within 6 months after discontinuing ribavirin therapy. You must use 2 forms of birth control when you take ribavirin and for the 6 months after treatment.

    Females must have a pregnancy test before starting ribavirin, every month while taking ribavirin, and every month for the 6 months after the last dose of ribavirin.
    If you or your female sexual partner becomes pregnant while taking ribavirin, tell your healthcare provider right away. You or your healthcare provider should contact the ribavirin pregnancy registry by calling 1-800-593-2214. The ribavirin pregnancy registry collects information about what happens to mothers and their babies if the mother takes ribavirin while she is pregnant.

Advocate1955
Blank
1747881_tn?1358189534
Blank
Avatar_m_tn
This needs to be registered and you will get info. from them also.
Best ..
Will


http://www.ribavirinpregnancyregistry.com/
Blank
Post a Comment
To
Blank
Weight Tracker
Weight Tracker
Start Tracking Now
Hepatitis C Community Resources
RSS Expert Activity
233488_tn?1310696703
Blank
New Cannabis Article from NORTH Mag...
Jul 20 by John C Hagan III, MD, FACS, FAAOBlank
242532_tn?1269553979
Blank
3 Reasons Why You are Still Binge E...
Jul 14 by Roger Gould, M.D.Blank
242532_tn?1269553979
Blank
Emotional Eating: What Your Closet ...
Jul 09 by Roger Gould, M.D.Blank
Top Hepatitis Answerers
Avatar_f_tn
Blank
dontworry_behappy1
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
Avatar_f_tn
Blank
nan535
Brooklyn, NY
446474_tn?1404424777
Blank
HectorSF
CA
1815939_tn?1377995399
Blank
pooh55811
96938_tn?1189803458
Blank
FlGuy
South, FL