Aa
spontaneous clearance
I believe that in 15 to 20% of HCV contaminated people there will be a spontaneous clearing of the virus. Has anyone ever researched why these people will clear while others won't.
ya if anyone could clear on their own, its keith richards .... i sincerely hope he considers donating his body to science when and if... ... he should donate some of his blood for studies right now if you ask me
good genes help also, both his mother and father lived well into their 80/90's and i believe his father was a life long hard drinker and smoker... there is hope for me yet sounds like my family LOL
good genes help also, both his mother and father lived well into their 80/90's and i believe his father was a life long hard drinker and smoker... there is hope for me yet sounds like my family LOL
it all has to do with your immune system... ask keith richards... lol"
I never thought about it but even regardless to all the drugs he's had his blood changed so many times I wonder how many strains of hep he's had?!!!!! Good point PJ! ;)
I never thought about it but even regardless to all the drugs he's had his blood changed so many times I wonder how many strains of hep he's had?!!!!! Good point PJ! ;)
Hum, it makes me wonder if those of us who historically have low baseline VLs could have been infected prior and never known it or something like that. Interesting to me as I admit to having several different times in my life I could have gotten this disease (decades, not dates) that are so far apart.
Protection but not guarantee is the important thing I guess to remember.
Protection but not guarantee is the important thing I guess to remember.
Spontaneous Control of Primary Hepatitis C Virus Infection and Immunity against Persistent Reinfection.
Osburn WO, Fisher BE, Dowd KA, Urban G, Liu L, Ray SC, Thomas DL, Cox AL.
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
BACKGROUND & AIMS:: We followed persons with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:: Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C viremia for at least 60 days were monitored monthly. Reinfection was defined as the detection of a new hepatitis C virus infection. Protection was assessed based on the magnitude and duration of viremia following reinfection and generation of T-cell and neutralizing antibody (nAb) responses RESULTS:: Reinfection occurred in 11 IDUs (50%) who previously spontaneously controlled primary HCV infection. Although viral clearance occurs in approximately 25% of patients with primary infections, spontaneous viral clearance was observed in 83% of reinfected patients. The duration and maximum level of viremia during subsequent episodes of reinfection were significantly decreased, compared with those of the primary infection in the same subjects. In contrast to chronic infection, reinfection was associated with a significant increase in the breadth of T-cell responses. During acute infection, nAbs against heterologous viral pseudoparticles were detected in 60% of reinfected subjects; cross-reactive nAbs are rarely detected in patients who progress to chronic infection. CONCLUSIONS:: HCV reinfection is associated with a reduction in the magnitude and duration of viremia (compared with the initial infection), broadened cellular immune responses, and the generation of cross-reactive humoral responses. These findings are consistent with the development of adaptive immunity that is not sterilizing but protects against chronic disease.
http://tinyurl.com/yc98mee
Mike
Osburn WO, Fisher BE, Dowd KA, Urban G, Liu L, Ray SC, Thomas DL, Cox AL.
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
BACKGROUND & AIMS:: We followed persons with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:: Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C viremia for at least 60 days were monitored monthly. Reinfection was defined as the detection of a new hepatitis C virus infection. Protection was assessed based on the magnitude and duration of viremia following reinfection and generation of T-cell and neutralizing antibody (nAb) responses RESULTS:: Reinfection occurred in 11 IDUs (50%) who previously spontaneously controlled primary HCV infection. Although viral clearance occurs in approximately 25% of patients with primary infections, spontaneous viral clearance was observed in 83% of reinfected patients. The duration and maximum level of viremia during subsequent episodes of reinfection were significantly decreased, compared with those of the primary infection in the same subjects. In contrast to chronic infection, reinfection was associated with a significant increase in the breadth of T-cell responses. During acute infection, nAbs against heterologous viral pseudoparticles were detected in 60% of reinfected subjects; cross-reactive nAbs are rarely detected in patients who progress to chronic infection. CONCLUSIONS:: HCV reinfection is associated with a reduction in the magnitude and duration of viremia (compared with the initial infection), broadened cellular immune responses, and the generation of cross-reactive humoral responses. These findings are consistent with the development of adaptive immunity that is not sterilizing but protects against chronic disease.
http://tinyurl.com/yc98mee
Mike
In Hollywood it's very easy to isolate the substance from those who are immune or clear viruses spontaneously. Then just as easy to create a vaccine in a garage to cure the masses. If only it were that easy in non 555 areas. :o(
Actually in a retrospective study the researchers looked at 26 different studies and found between 25-40% of patients cleared hepatitis C spontaneously. Spontaneous clearance was more common in females than males and in people who did get their hep C from a transfusion.
I suspect that it will be correlated in the future with the genetics of the infected. That study was just published by Duke University scientists August 17th and it will be a while before all of the ramifications will surface.
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