Hello
I am so grateful for your patience and knowledge and thank you for all your amazing input. i am new here and learning to use all the sites, janis included. i will be passing all this information along to my husband and doctors. i am trying very hard myself to be one step ahead and knowledgable of the lingo. this is a detailed disease but i am getting it now thanks to all you wonderful people who are willing to help others.
i will try to slow down on the postings - lol
have a wonderful day
leslie
Hi Leslie,
Stage and grade are determined by biopsy. There are several scales in use currently; the most widely used in industrialized nations now is probably the ‘Metavir’ grading system. The degree of fibrosis, or scarring is measured on a scale of 0 through 4; with stage 4 signaling cirrhosis. This staging system tells us how much scarring has already occurred.
There is also a similar measurement that quantifies the current activity of inflammation; scored A0 through A3, I believe.
So, for instance, my last biopsy showed grade 3 activity, stage 3-4; significant fibrosis/scarring.
This is how the progression of disease is measured, rather than using viral load measurements to judge how far the disease has gotten.
See also:
http://janis7hepc.com/home9.htm
For more info on grade and stage of liver disease.
Best to you and your husband—
Bill