twenty-two days

[bluemetal]

Has anyone discontinued tx on sovalldi-olysio before completing the 84 days? Im a Gt 1a  F-4 cirrhotic. Had no prior tx until now. Started the S-O combo on 7/16/14. Terminated tx 8/6/14, twenty-two days later due to rare but serious side effect. Not from the drug combo per se but probably due to some other unrecognized medical condition. (Currently being looked into). Blood work is due 8/11/14 to detrmine whether the 22 days had any impact on the virus. Must now place entire hope on isolating cause for terminating tx and wait for that miracle drug coming in Oct.

[bluemetal]

Yes, the Phase 3 ION-2 study. Funded by Gilead Sciences, completed Feb 2014. 440 subjects. It was than expanded across 53 locations throughout the U.S involving more than 10,000 patients to cover a diverse population, some receiving the S/L combo, others getting S/L/R . The clinical directors decided that among the 200 cirrhotic patients in the first arm treated 12 weeks, only 4% relapsed, therefore, the tx duration was set at 12 weeks. The Phase 2 ELECTRON trial however, led to the SYNERGY study which proved that adding a third direct-acting antiviral, either GS-9669 or GS 9145 (Gileads secret ingredient witheld from competitors) maintained a cure rate of 95-100% after 6 weeks of tx. THIS will be the tri-contents of Gileads forthcoming miracle drug in autumn. 1 pill a day for 42 -84 days (depending on individual case). All genotypes, cirrhotics included. If its not a fairy tale to boost stock than we are about to become part of medical history. The only fly in our imaginary soup is price. This drug is coming with a price tag that will literally break the proverbial back of that medicare-toting camel unless good old uncle Sam prevails in the ongoing hearing where Gileads CEO's and president are, this very moment, on a sort of trial themselves to answere for their outragous pricing.  Finally, in the words of one ofmy favorite Dickens characters..."God bless us everyone".

[Dee1956]

I am really sorry to hear about your experience.  It is awful to have a side effect was not reported during the trials.  I  am really sorry.

I did Incivek when it was first approved, I had problems that my doctor was not aware of since the drug had not been out very long.

Take Care
Dee

[candyce1953]

http://files.easl.eu/easl-recommendations-on-treatment-of-hepatitis-C.pdf

EASL conference re treatment and treatment recommendations all new nn inter we've rom treatments

[bluemetal]

Two hours ago, following my zillionth medical visit, I was in my time machine (purple Pontiac Sunfire 2.2 liter) doing 60mph on a two-lane blacktop along a rural trafficless back mountain road listening to Alice-In-Chains singing a rock blues ballad called Would...    "Know me broken by my master, Teach thee on child of love hereafter. Into the flood again, same old trip it was back then. So I made a big mistake, try to see it my way...Am I wrong? Have I run too far to get home? If I would, could you?"... Its a song directed toward people who pass judgements. Also the soundtrack to the movie Singles. Its relevance to this post: ours is a stigmatized disease associated with drugs, sex, uncleanliness even though many of us contracted it through blood transfusion or accidentally. Ive moved well beyond the judgemental persecution stage and am free. Whether Im cured or not is of little consequnce, Ive accepted it either way and as such have liscense to live life to the fullest NOW. Like flying around curves on rural back roads at death-defying speeds. I feel somuch better after my hiway fix.        On a more boring note: my labs on the HCV RNA viral load after that 22-day S+O trip will be ready friday. Ill post for those interested.

[bluemetal]

Finally, a touch of Realism. The bottom line: hope for the best but expect the worse. Ive got another medical appointment in 1 hour so Ill get back online later. In fact theyve lined up so many appointments for me that Im starting to feel like a lab rat. At least my med team is concerned (or perhaps 'curious' as all scientists) My recent blood test results should be back by friday. Ill post then. In the meantime I suggest everyone research as much as possible Gileads forthcoming miracle cure.. that single once-a-day pill that alledgidly has a 100% cure rate in all genotypes. Balance hope with despair and keep it REAL.

[candyce1953]

I just cured after 43 years on Sovaldi olysio, started May 8, SVR last week 24 weeks ago (12 of treatment) I was 1 b though

(I have read 1a cirrhotic have cured on 24 weeks of Sovaldi Oylsio )
Or

Gilead Sovaldi and Bristol Meyers Daclastasir  
That is the one with highest percentage cure

Read the EASL CONFERENCE treatment suggestion
Good luck
Xoxo