Sorry, I misunderstood your point.
No herpes drug causes depression or weight gain. But if you or your doctor think it's possible, discuss stopping the drug for a few weeks and see if those problems improve. But I doubt it will make any difference.
Sorry I didn't clarify it's the medication I'm on i know it is causing the joint pain and weight gain.
Herpes doesn't cause joint pain. You'll need to work with your doctor to diagnose the cause of this symptom. Good luck.