Hi, I'm glad I found this site. I am 49, and had a full hysterectomy at the age of 34. I was put on replacement right away. At 41 I got a blood clot in my brain. That stopped all hrt. Six months later I stumbled on an article about bio identical hormones. I found a doctor who prescribed them, and over the last eight years I have struggled with on going symptoms while using the bio cream (supposedly there are no clotting factors with cream). So, I gave up taking it in October of 2012. Well, over the last three months I have gotten worse and worse. I thought I had some serious illness. I have had horrible fatigue, severe irritability, my mood is all over the place, and this is just a few of my symptoms. So, today I came across an article on menopause and the symptoms that go along. Duh!!!! I am having symptoms of not having hormones in me. It just never occurred to me that this would happen, I figured just hot flashes would be there. Hot flashes have been apart of my life since I stopped the estratest HR. The bio cream never really helped with with hot flashes. So anyway after all this, I want to know if at my age is it even ok to start the bio hormones again, or should I just stay the course and stay off of them? I have looked thru the internet and I can't find information specific enough for my situation. Thank you so much for any information given.