My friend was diagnosed about 15 yrs ago with hep c from a blood transfusion he received at a military facilty as he was serving his 24 years in Special Forces. He is Type 1 A and both times received interferon 2A and ribovarin; and neither time responded positively to it.
His MELD is a 9; and I have noticed the red dots on his skin; as well as him having an enlarged spleen; feverish flu like symptoms immediately if he is around people with colds. His plalets are down to 85; a drop from 124 back in Oct 2009.
My question is - are there any clinical trials or new medications that are coming out over the next 2 years to help his symptoms. He no longer drinks and eats a healthy diet. His doc wants to try the txt again - is this advisable or can you recommend a clinical trial phase 3 or 4 that may benefit him knowing his genotype.
there are many small molecules that are in the pipeline for HCV that will be coming to clinical trial. Most are protease inhibitors--we are hoing that 1 or 2 of them may be FDA-approved by this time next year. There are no panceas--all new meds will be used with interferon-based therapy. consensus interferon is another possibility. as you have cirrhosis do not forget to have regular screening for HCC. i think its reasonable to consider re-Rx.
Thank you for your information and getting back to me so quickly. As I reviewed your profile, you indicate that you are interested in herbal treatments and nutrition management for liver disease. I am interested in knowing your recommendations as my friend takes quite a bit of vitamins and some supplements for liver cleansing and support. His diet is lite, minimal meat and has lost about 17 lbs since the beginning of the year.
Also, I want to confirm that you do recommend consideration of txt again for treating HCV.
Have you heard about the new drug that Bristol Myers-Squibb is working on - not a protease inhibitor but focused on a protein blocking the virus from spreading? News came out on the 17th of April
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