I had lab work back in March and everything was normal except my cholesterol levels. I changed my diet and started walking more. I lost 20lbs, but then started having some right upper abdomen pain and nausea along with extreme fatigue. I was seen in the ER and noted on the CT scan that my liver was abnormal. I had more labs drawn and my ALT/SGPT was high at a 99, my alkaline phosphatase was high at a 130, my AST/SGOT was high at a 181, my platelet volume was high at a 11.5, and my bilirubin level was high at a 1.30. I had a follow up visit with my PCP and she said that this is all due to me being over weight. I am overweight, but I am not huge by any means and all this tested normal when I was at my heaviest. Why would the levels jump significantly after I lose weight and should I be concerned?