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Liver Transplant (Expert Forum)
chronic hepatitis B
Answered by
Thomas D Schiano, MD - Internal Medicine, Gastroenterology, Liver Transplantation, Hepatology
The Mount Sinai Medical Center
New York - NY
Questions posted in the Liver Transplant . Forum are answered by medical professionals from The Mount Sinai Medical Center.
chronic hepatitis B
by hingmary, Sep 29, 2009 08:53PM
tag :Liver cirrhosis
I've got hepatitis B since 1985 ,any symtom to appear ,HBsAg positive, HBc IGm ,IGg positive ,others tests not at all( normal levels). I don't care about it, 2008 march i've got test blood detail as under : transaminases SGPT 39 ui/l SGOT 34 ui/l HBsAg positive ,DNA/HBV/PCR: 10.300 copies/ml . I got lamivudine 100 mg /day vitamine E 4oo ui /day, orange juice everyday 50 cc/day ,and others fruits,2 months later my blood test showed DNA/HBV/PCR negative (<200 copies ),checked regularly every 3 months untill now still negative level. SGPT 75- 90 ui/ml constantly,never down a normal range,since 2008 March untill now. HBsAg negative level ,HBsAb negative level ,others test are normal levels .Is i got recovery from Hepatitis B ? why transaminases still up level normal ? Due to i got lamivudine 100mg make transaminases up level regularly ? I fear carcinoma (HCC) eventually, i was not a drinker ,after recovery can i drink some alcoohol a little quantity about (once)15 ml whyski weekly ?, When i stop take lamivudine 100 mg ?
Thanks&Regards
Hing mary
I've got hepatitis B since 1985 ,any symtom to appear ,HBsAg positive, HBc IGm ,IGg positive ,others tests not at all( normal levels). I don't care about it, 2008 march i've got test blood detail as under : transaminases SGPT 39 ui/l SGOT 34 ui/l HBsAg positive ,DNA/HBV/PCR: 10.300 copies/ml . I got lamivudine 100 mg /day vitamine E 4oo ui /day, orange juice everyday 50 cc/day ,and others fruits,2 months later my blood test showed DNA/HBV/PCR negative (<200 copies ),checked regularly every 3 months untill now still negative level. SGPT 75- 90 ui/ml constantly,never down a normal range,since 2008 March untill now. HBsAg negative level ,HBsAb negative level ,others test are normal levels .Is i got recovery from Hepatitis B ? why transaminases still up level normal ? Due to i got lamivudine 100mg make transaminases up level regularly ? I fear carcinoma (HCC) eventually, i was not a drinker ,after recovery can i drink some alcoohol a little quantity about (once)15 ml whyski weekly ?, When i stop take lamivudine 100 mg ?
Thanks&Regards
Hing mary
Doctor's Answer
by Thomas D Schiano, MD, Sep 30, 2009 05:03PM
, Sep 30, 2009 05:03PM
once the lamivudine has been started it is difficult to discontinue it without changing it to another medication. it is possible that you have developed resistance and may need to check a viral level and if (+) be switched to another medication. Resistance is very common with lamivudine use. a CT scan or U/s should also be checked.
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I understood what you explained me about it. Should I check blood test on HBV/DNA/PCR or HBsAg (Quantity) ? If resistance of lamivudine, what name of the drug will be changed?
- If the HBsAb become Positive level, my liver working well or not?
- What drugs can't I use? (Avoid hepatotoxic) when I got diarrhea - Headache or fever.
Now should I stop take lamivudine?