I am 47 yrs. old and diagnosed with MS in March 2015. The only physical symptom I have is that my left leg turns weak after walking for about 20 minutes. I then need to rest for 15-20 minutes and I am able to walk again. On my first MRI, I had 9 markers/lesions. I tried Tecfidera in May and had a terrible reaction to it once I started the full dosage. My face swelled up and eyes swelled shut. I looked like I had been in a bar room brawl. So, my neurologist took me off Tecfidera and had me start Plegridy.. I took my first dose on June 13th (63mg?), 2nd dose on June 27 (95mg?) and my first full dose (125mg?) tonight. The first 2 doses I got a large red splotch at the injection site. It doesn't usually itch or swell, I can just see it. Tonight, after my injection, I have a very dry mouth and drinking lots of water and also have a slightly jittery feeling. My husband said I am running around like a crazy person. Has anyone had any of these reactions after taking their full dose injections? If so, does it change or should I expect to feel this way each time? Any input would be appreciated. Thanks.