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HIGH ANA TITER
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HIGH ANA TITER

Dear Doctor,
My daughter became quite ill with Fifth's Disease when she was 6 yrs. old.  She had joint aches, mild fever, facial rash, and general fatigue.  Bloodwork done showed positive for the parvo virus titer.  But also had  done ,with routine bloodwork, an ANA profile, which was very high, like in the 1000's.    Her illness resolved itself in a few weeks and she's been fine since.  She's now 13, and is very healthy, but since the ana was so high, my pediatrician has followed it yearly.  It can be so high, like in the 1,000's to as low as 1:320.   He is uncertain as to what this means, also, but feels someday she may develop some autoimmune type illness, such as lupus.  Could you give me your opinions, and what course of action, if any, to take?  I understand, that high ANA's are insignificant, if there are no other symptoms, but feel that this is so high, I should be doing more for her, like maybe a specialist?  If there's any signifigance to this, I am white american, but my husband is Vietnamese.  Also, does this mean she has a higher incidence of someday developing M.S.?
Thanks for any help
Christine G.
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Dear Christine:

An ANA titer can mean many things because the test is non-specific.  When cells die, the contents that are now released can be seen as foreign and antibodies made.  In 5th disease, cells die and it is not uncommon to see non-specific antibodies made, such as ANA.  In autoimmune disorders, there is also cell death and ANA antibodies can be found.  Once an antibody is made, it can stick around for many years, and if cell death is occurring (which happens all the time) antibodies can be renewed and titers elevated.  If one is questioning lupus, then fragmentation of the ANA antibody types might be useful, also clinical signs, other lab results such as complement, sedimentation rate etc can be done to verify SLE.  I would take a wait and see attitude and watch for clinical signs if you are worried.  I would not be too worried at this point.

I hope I helped you some.

Sincerely,

CCF Neuro MD
5 Comments
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Dear Doctor,
Thank you so very much for your prompt reply. The service you provide is excellent.   I have tried for YEARS  to post that question.  All the other bloodwork you mentioned, sed rate, and various other tests, all proved to be normal. Her ANA is just so temperamental!!!!   Your advice is the same as my pediatrician's, to just not worry about it.  Thank you again for the added peace of mind.
Sincerely,
Christine
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I too have not been able to log on and ask the doctor a question.   His answer here to this post was in part an answer to one of my concerns.  Thanks.
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To Becky,
If you see this, I read your Sept. 8 posting.  You mentioned some concerns?  Would you mind re posting and filling me in on what was worrying you?
Christine
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i just recently had some test done on my thyroid and some of the results are confusing and my doctor says that she doesnt have time to discuss this with me, so i was wondering if you could help explain.  my ana titer is 1:40 speckled.  i have no idea what that may mean.  she has says i am hyperthyroid and hypothyroid. how can that be?  thank you deitra
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A related discussion, ANA SCREEN POSITIVE,PATTERN SPECKLED,TITER1:80 was started.
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A related discussion, hypothyroid and high ANA was started.
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A related discussion, Is there really a way to test for Lupus was started.
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Dear Doctors,
I just currently took a few blood tests with my dr because I've been having alot of unexplained pain in my joints and muscles. My back always hurts I get killer migraines and the heel of my foot is umbareanle to walk on anymore and I'm ALWAYS tired. It's hard to keep my eyes open anymore. My blood work says my anachoice screen was positive, my ana titer was 1:80 and the pattern was speckled. My C3 serum was 135 and my C4 serum was 35 my DNA (ds) antibody was 10H   I am completley confused because my dr didn't explain any of this to me he just referred me to a rheumotologist. Please help me understand what all of this means I'm going insane trying to figure this out.
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