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Neurology (Expert Forum)
Treatment of Depression with Nardil (MAO) and Tegretol
This forum is for questions and support regarding neurology issues such as: Alzheimer's Disease, ALS, Autism, Brain Cancer, Cerebral Palsy, Chronic Pain, Epilepsy, Fibromyalgia, Headaches, MS, Neuralgia, Neuropathy, Parkinson's Disease, RSD, Sleep Disorders, Stroke, Traumatic Brain Injury.
Doctor's Answer
by CCF Neuro[P] MD, RPS, Dec 15, 1999 12:00AM
Dear Candy:
The vast majority of side effects from Nardil are from the interactions with foods and other medications. Tegratol is not one of the direct interfering medications and food. It takes several weeks for Nardil to have it's psychiatric effects. The biological action of Nardil is to irreversibly bind to the MAO enzyme located outside the mitochondrial membrane. Most medications are metabolized by the liver but I am not sure if there is activiation of the cytochrome P450 system (I don't think so and the Pharmacology texts seem to not mention it). To be on the safe side, I would monitor the tegratol level once you reach your target Nardil dose. Of course, if you have a breakthrough seizure I would monitor the level at that point.
Be sure you are aware of the interacting medications and I hope you do not eat alot of cheddar cheeze.
Sincerely,
CCF Neuro MD
The vast majority of side effects from Nardil are from the interactions with foods and other medications. Tegratol is not one of the direct interfering medications and food. It takes several weeks for Nardil to have it's psychiatric effects. The biological action of Nardil is to irreversibly bind to the MAO enzyme located outside the mitochondrial membrane. Most medications are metabolized by the liver but I am not sure if there is activiation of the cytochrome P450 system (I don't think so and the Pharmacology texts seem to not mention it). To be on the safe side, I would monitor the tegratol level once you reach your target Nardil dose. Of course, if you have a breakthrough seizure I would monitor the level at that point.
Be sure you are aware of the interacting medications and I hope you do not eat alot of cheddar cheeze.
Sincerely,
CCF Neuro MD
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Thankyou, Tessa