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Ovarian Carcinosarcoma
My Wife was Dx with Ovarian Carcinosarcoma stage 3c in Mar of 2006 which had also invaid her Colon.She also had Secondery Prymary Brest Cancer. After 8.5 hr Surgey to remove Tuomer (size of 20week pregnace she was placed on Caisplatin for 6 rounds every 3 week.
Now here is the Question, Form all I har read about this Cancer she should not be still clear. I don't mean to look a geft Horse in the Mouth . But is there a Posabilty that she could have been miss Dx. Her ca 125 is <5 and was never over 35.
She is being treated at the Ingrem Cancer Center Vanderbilt Unv. Med. Center in Nachville Tn.
Now here is the Question, Form all I har read about this Cancer she should not be still clear. I don't mean to look a geft Horse in the Mouth . But is there a Posabilty that she could have been miss Dx. Her ca 125 is <5 and was never over 35.
She is being treated at the Ingrem Cancer Center Vanderbilt Unv. Med. Center in Nachville Tn.
Thank you for your response of Jan 15th. As I am not a "Medic" it is quite difficult to understand the article you posted re;my friend with SCCD as the survival rates quoted were associated with SCCE. Please could you clarify the survival rates of women with SCCD.
Many thanks, Elaine.
Many thanks, Elaine.
MEDICAL PROFESSIONAL
Dear Elaine,
The survival rates of women is described in the article that I previously pasted.
The bigger issue is whether you as a friend should suggest medical management. You are being put in a tough position. As a non-medical friend, you could try to steer your friend to a doctor that she trusts and can work with.
best wishes
The survival rates of women is described in the article that I previously pasted.
The bigger issue is whether you as a friend should suggest medical management. You are being put in a tough position. As a non-medical friend, you could try to steer your friend to a doctor that she trusts and can work with.
best wishes
Thank you so much for such a quick response. My friend is 42 years of age a single parent with a very young child.. She has been told about chemo surgery and then chemo after surgery however she feels going through such drastic measures unless there is good cause to think this would be of major benefit would destroy any quality of life she may have. As she sees me as a mentor being older than she how am I meant to answer her.
I am fully aware such treatment can in itself take such an affect on her quality of life yet on the other hand would it be wrong not to give the above a try.
If she does nothing what sort of timescale does she have as I need to try and help her do what is best for her child.
Respectfully yours,
Elaine.
I am fully aware such treatment can in itself take such an affect on her quality of life yet on the other hand would it be wrong not to give the above a try.
If she does nothing what sort of timescale does she have as I need to try and help her do what is best for her child.
Respectfully yours,
Elaine.
MEDICAL PROFESSIONAL
Dear Elaine,
Squamous cell carcinoma arising in a dermoid is rare.
squamous means skin.
A dermoid is a benign tumor of the egg cell in the ovary. It is the most common type of tumor of the ovary. It is usually benign. In a benign dermoid, there are tissues from the many cell types that make up the human body. For instance, it is common to see hair, skin, fat, bone, thyroid tissue, cartilage, brain tissue and so forth. rarely, one of those tissues has a malignant transformation.
Most commonly, the thyroid tissue can be malignant. But sometimes other components can such as the skin.
Stage III means that the cancer has spread off the ovary to either involve the upper abdomen or the lymph nodes. Unfortunately, the prognosis is not very good if there has been spread. the standard treatment is to surgically remove what can be removed and then give chemotherapy. I have pasted an article below on the topic.
I hope your friend does well. It would be best if she could be seen by a specialist in gyn cancers
best wishes
Primary Squamous Cell Carcinoma of the Ovary: Report of 37 Cases.
Original Article
American Journal of Surgical Pathology. 20(7):823-833, July 1996.
Pins, Michael R. M.D.; Young, Robert H. M.D.; Daly, William J. B.A.; Scully, Robert E. M.D.
Abstract:
A total of 37 cases of ovarian primary squamous cell carcinoma (SCC)-19 associated with a dermoid cyst (SCCD), seven associated with endometriosis (SCCE), and 11 pure (SCCP)-are described. The last 18 cases belong within the new World Health Organization category of SCC in the surface epithelial-stromal category. The 19 patients with SCCD were 21-75 (mean, 52) years old; three of the carcinomas were in situ and seven, six, and three tumors were stages I, II, and III, respectively. The tumors and associated dermoid cysts were 6-35 cm in greatest dimension, usually forming mural nodules with intracavitary protrusion and focal necrosis and hemorrhage; two, seven, and seven tumors were grades 1, 2, and 3, respectively. SCCD was focally associated with a columnar epithelial cyst lining in 13 cases, suggesting an origin therein. One patient with stage I, grade 1 SCCD also had squamous cell carcinoma in situ (CIS) of the cervix. The seven patients with SCCE were 29-70 (mean, 49) years old, and one, three, one, and two tumors were stages I, II, III, and IV, respectively; all of the tumors were grade 3. One was associated with squamous cell carcinoma in situ of the cervix. The 11 patients with SCCP were 27-73 (mean, 56) years old, and one, four, five, and one tumors were stages I, II, III, and IV, respectively. The tumors were 6-26 cm in greatest diameter, usually solid with focal necrosis; one and 10 tumors were grades 2 and 3, respectively. Three patients with SCCP also had cervical squamous cell carcinoma in situ. The patients with SCCE had a poorer overall survival than those with SCCD. Five of the six patients with SCCE for whom adequate follow-up information was available died of their disease (mean survival, 5 months); also, in all five cases of SCCE reported in the literature, the patients died of their disease (mean survival, 4 months). The stage of the tumor and its grade correlated best with overall survival for all three types of SCC.
Squamous cell carcinoma arising in a dermoid is rare.
squamous means skin.
A dermoid is a benign tumor of the egg cell in the ovary. It is the most common type of tumor of the ovary. It is usually benign. In a benign dermoid, there are tissues from the many cell types that make up the human body. For instance, it is common to see hair, skin, fat, bone, thyroid tissue, cartilage, brain tissue and so forth. rarely, one of those tissues has a malignant transformation.
Most commonly, the thyroid tissue can be malignant. But sometimes other components can such as the skin.
Stage III means that the cancer has spread off the ovary to either involve the upper abdomen or the lymph nodes. Unfortunately, the prognosis is not very good if there has been spread. the standard treatment is to surgically remove what can be removed and then give chemotherapy. I have pasted an article below on the topic.
I hope your friend does well. It would be best if she could be seen by a specialist in gyn cancers
best wishes
Primary Squamous Cell Carcinoma of the Ovary: Report of 37 Cases.
Original Article
American Journal of Surgical Pathology. 20(7):823-833, July 1996.
Pins, Michael R. M.D.; Young, Robert H. M.D.; Daly, William J. B.A.; Scully, Robert E. M.D.
Abstract:
A total of 37 cases of ovarian primary squamous cell carcinoma (SCC)-19 associated with a dermoid cyst (SCCD), seven associated with endometriosis (SCCE), and 11 pure (SCCP)-are described. The last 18 cases belong within the new World Health Organization category of SCC in the surface epithelial-stromal category. The 19 patients with SCCD were 21-75 (mean, 52) years old; three of the carcinomas were in situ and seven, six, and three tumors were stages I, II, and III, respectively. The tumors and associated dermoid cysts were 6-35 cm in greatest dimension, usually forming mural nodules with intracavitary protrusion and focal necrosis and hemorrhage; two, seven, and seven tumors were grades 1, 2, and 3, respectively. SCCD was focally associated with a columnar epithelial cyst lining in 13 cases, suggesting an origin therein. One patient with stage I, grade 1 SCCD also had squamous cell carcinoma in situ (CIS) of the cervix. The seven patients with SCCE were 29-70 (mean, 49) years old, and one, three, one, and two tumors were stages I, II, III, and IV, respectively; all of the tumors were grade 3. One was associated with squamous cell carcinoma in situ of the cervix. The 11 patients with SCCP were 27-73 (mean, 56) years old, and one, four, five, and one tumors were stages I, II, III, and IV, respectively. The tumors were 6-26 cm in greatest diameter, usually solid with focal necrosis; one and 10 tumors were grades 2 and 3, respectively. Three patients with SCCP also had cervical squamous cell carcinoma in situ. The patients with SCCE had a poorer overall survival than those with SCCD. Five of the six patients with SCCE for whom adequate follow-up information was available died of their disease (mean survival, 5 months); also, in all five cases of SCCE reported in the literature, the patients died of their disease (mean survival, 4 months). The stage of the tumor and its grade correlated best with overall survival for all three types of SCC.
A related discussion, UPDATE PLEASE was started.
MEDICAL PROFESSIONAL
Dear Elaine
I have pasted the relevant sentence from that abstract here:
Five of the six patients with SCCE for whom adequate follow-up information was available died of their disease (mean survival, 5 months); also, in all five cases of SCCE reported in the literature, the patients died of their disease (mean survival, 4 months).
basically what it says is that everyone died in 4 to 5 months except for one person. I am so sorry. this is grim
take care
I have pasted the relevant sentence from that abstract here:
Five of the six patients with SCCE for whom adequate follow-up information was available died of their disease (mean survival, 5 months); also, in all five cases of SCCE reported in the literature, the patients died of their disease (mean survival, 4 months).
basically what it says is that everyone died in 4 to 5 months except for one person. I am so sorry. this is grim
take care
I have found the emails of rabbit696 very relevant and helpful. Would the email of Jan 5th signed Elaine be addressed soon as I very much would find the reply of great benifit. I
Thank you so much,
london56
Thank you so much,
london56
I have found the emails of rabbit696 very relevant and helpful. Would the email of Jan 5th signed Elaine be addressed soon as I very much would find the reply of great benifit. I
Thank you so much,
london56
Thank you so much,
london56
I have a close friend who has been diagnosed Squamous Cell Carcinoma in Dermod Cyst.
However it seems this is very rare and the hospital here in England have said it is something they havent come across before.
Could you be goot enough to enlighten us if you can. She has been told it is at stage 111.
Thanking you in advance,
Elaine.
However it seems this is very rare and the hospital here in England have said it is something they havent come across before.
Could you be goot enough to enlighten us if you can. She has been told it is at stage 111.
Thanking you in advance,
Elaine.
MEDICAL PROFESSIONAL
hi there,
I agree with bgal. some tumors do not make the CA 125 protein. Your wife is cared for at a very good center. I would trust their assessment
best wishes
I agree with bgal. some tumors do not make the CA 125 protein. Your wife is cared for at a very good center. I would trust their assessment
best wishes
While it is always possible that your wife was misdiagnosed, I would not base my thinking on the CA125 numbers. The reason doctors DO NOT use the CA125 test to determine Ovarian Cancer is that it is not necessarily a reliable measure. Frequently women will present with a false-positive response which may indicate there IS the presence of cancer when, in fact, there is not. The reverse is likely also. I do not understand what you mean by "still clear". Do you mean that all the cancer has been removed or killed by the chemo? Do you mean that following her surgery she is now all "clear" and has no more cancer?
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