PARP Trials USA

I am an ovarian cancer survivor with BRCA1 gene and currently have one lymph node with ovarian cancer.  I am interested in getting into a PARP trial.  What do you know about open trials in the US right now?  Thanks.

[Ramsay14]

They are having the topotecan+bsi-201 trial at Yale in Connecticut and at Sloan Kettering in NYC.  I don't know where you live and if these locations are convenient to you.  There are a couple of other locations that are giving this particular trial now as well, but you'd have to check www.clinicaltrials.gov.

[lucymullis]

Is your lymph node measureable?  That's required of most parp trials.

Sloan doesn't have a parp trial now. There is one at NIH in Bethesda that has been put on hold due to toxicity some of the enrollees had but will most likely open back up this month or next. I went to the FORCE conference to hear about Parp.  I did learn that it is promising; however, a few women experience reversal of their parp gene, which sounds good, but it is not.  What it meant for them is that their cancer became platinum resistant. Here are the most promising ones I found.  As mentioned above, www.clinicaltrials.gov is where you can research them.  However,that database isn't always current so it's best to call.  
1. Phase I MK4827 in Patients With Advanced Solid Tumors and BRCA Mutant Ovarian Cancer. (in Florida)
2. Phase I AZD2281 and Carboplatin in Treating Patients With BRCA1/BRCA2-Associated or Hereditary Metastatic or Unresectable Ovarian Cancer. (NIH in Bethesda, Md.  they pay your flight expenses).
3. Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patients
4.3. Phase II Assessment of Efficacy of AZD2281 in Platinum Sensitive Serous Ovarian
Cancer (Fla. and NY)  

Hope this helps.  I was strongly considering it; however, even with no evidence of disease, my ca125 went from 190 to over 1100 this past month so I'm starting chemo asap.  Cancer *****.

[Ramsay14]

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