I am suffering from depression and anxiety. I recently saw my psychiatrist, and he prescribed Effexor (37.5mg a week until I get to 150mg) to treat these conditions. I have been smoking marijuana regularly (daily) for about 5 years now, and it helps me with my lower back pain that I get from an injury that left me with 4 herniated discs, on top of helping with my depression. Obviously it is not helping enough with the depression to be enough, which is why I went to see my psychiatrist. My main concern is with the interaction that taking the Effexor could have with the marijuana. I am willing to stop smoking if the interaction is bad, but that would pretty much force me to start taking 800mg Ibuprofen 3 times a day for my back pain, and I honestly don't know which one would be worse. I do not smoke cigarettes or drink alcohol AT ALL.