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Why doesn't percocet work for me?
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Why doesn't percocet work for me?

I was prescribed percocet10/650 mg for pain management after my recent foot surgery and also used it for when I had my ACL reconstructed.

I am not real knowledgeable about pain medication but am under the impression that this is a fairly powerful prescription.

I took it for both surgeries and have to say that it never touched the pain - in fact this time around - only the 1st 2 or 3 times I took it I felt a bit groggy and could feel the sedation effect.    I hallucinated once or twice when I took it for the knee surgery........

I am about 5' 5" and weigh about 150lbs - is there something in my system that doesn't allow the Percocet to do what it is supposed to do?  Or is there a secret that perhaps i don't know about......I also was prescribed 600mg of Motrin but unfortunately had a slight allergic reaction to that and was told to stop it.   I am extremely allergic to naprosyn and had major hives, facial swelling, and breathing difficulties last time I took that....

can you enlighten me on pain medications - I have a future surgery coming up on my knee and wanted to research or get a better understanding of what is available for me to help with postop pain.......many thanks....bugs64
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82861_tn?1333457511
I'm rather surprised to hear your doc started you out on percocet.  Most docs start with vicodin (5 mg hydrocodone) or vicodin ES (7.5 mg hydrocodone).  Have you ever tried vicodin?  In my years of adventures with pain, I have to say the vicodin works the best for me - but that's just me.  Percocet/percodan and morphine only puts my brain in the ozone and doesn't touch the pain.  Everyone reacts differently to the various opiate drugs.

Also, the word "painkiller" is really a misnomer.  There is not a magic pill out there that will reduce your pain to level zero.  The way opiates work is to fool your brain enough to where you really don't care about the pain or notice it any more.  What a shame you have such trouble with NSAIDS like motrin on naproxyn.  I've had 2 shoulder surgeries and 2 major neck surgeries, and those two drugs really helped me more than the narcotics.  However, there are a gazillion more NSAIDS out there to choose from, so maybe you could ask your doc about trying something else?
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Avatar_n_tn
thank you for your reply - i am definetly going to speak to my surgeon about this -

what's frustrating with the Naprosyn is that I used to take it for regular flare ups of the knee and then out of the blue one day I had this MAJOR allergic reaction.....of course, I didn't even consider it a reaction to the prescritpion because I just took one the night before and was fine.....I blamed it on everything from my fabric softner to body lotion.....valuable lesson to everyone out there especially on this particular forum in which prescription drugs are being discussed.......never take lightly a reaction to a prescription like I did - ignorance and playing "tough girl" could have cost me my life........Take care ...
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82861_tn?1333457511
Since you tend to react badly to various meds, you may want to research any new ones for side effects to watch out for in the future.  A really good web site for drug information is www. rxlist.com.  Just plug in the name of the medication, and you'll get pretty much everything known about it, including how it was studied, how many people were involved in the study, how many people reported what side effects, contraindications, overdosage information, etc.  It's been a very handy tool for me over the years.
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Avatar_n_tn
You may lack or have reduced amount of the liver enzymes required to create the active metabolites.  They are acually more potent painkillers than the oxycodone itself.  I was in the same situation as you after surgery when the percs didnt cut it.  They Dr. and nurse staff didnt believe me until I got really upset.  Well, they gave me some Dilaudid 4mg and let me tell you, pain be gone!   It is NOT a long-term med, but when you need to knock out the pain, nothing touches that stuff.  

I have heard of good results with the Fentanyl patch for longer term relief, but be VERY careful with this stuff and never take any other opiate or drink alcohol while its stuck to you.  People stop breathing.
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Avatar_n_tn
I really dont think that its a good idea to make the jump from 10mgs Oxy to Fentanyl.  I would imagine you would have to show that you are MUCH more opiate tolerant before doing that.  

Fentanyl can bring on respiratory depression *as so many others can* and there we're not even talking about the withdrawals.  Its not a short term medication and with pro-longed exposure you will enter into physical dependancy *not addiction (unless you have those problems), but depend.*.  When thats on the table you want to be very careful of what you are taking, how bad the withdrawals will be and how bad do they get. Some withdrawals can get bad enough to cause seizures or cardiac arrest in some individuals.  Be careful.

Percs of the 10mg variety are definately not weak, but there are certainly stronger things out there.  I cycle between Oxycontin 40mgs x 2 per day + Oxy Ir 10mgs x 5 and Hydrocodone/ibu 15/100 *compound*.  I/my doctor would rather have me cycle between those sistermeds than up my OxyContin up to 80mgs.   I have noticed that Hydrocodone seems to last longer in my system than pure Oxy IR for what ever reason (everyone is different and our bodies handle thins differently).  You may find that Hydrocodone works better for you, but I would imagine that you would need a compound of the 15-20mg variety if the 10mg Oxy dont cut it.  The other thing is that if this is long term pain then a 20mg Oxycontin might be an idea.  How ever if this is NOT long term I would avoid the OC.  

At last, trying to find alternatives that are non narcotic are always best, or even ones that could help you along with the rest.  Being pro active and trying the healthy alternatives is always best before stepping up onto something in the opiate family.  Pls remember also that any narcotic meds can/will cause your intestines to slow down so make sure you drink plenty of water, walk as much as possible and at times you may need to take a stool softener.
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Avatar_n_tn
Opiates are essentially a natural pain killer i.e. morphine and codiene, other ops are synthetic to some degree but derived from a natural substance. NASIDs like Naproxen are of little or no use for pain, you are better off icing the affected area.
NASIDs are dangerous to your stomach and other orgins especially over the long term, opiates will never cause you any problems aside from constipation which is easily dealt with.
In summary avoid anything other than ops, Drs will tell you otherwise because they are afraid of the DEA coming down on them, which is nonsence.Follow my threads and you will learn the propoer way to take these natural wonder drugs and forget the addiction issue unless your doctor threatens to cut you off.
I love ops and will take them until the day I die, pain or no pain!!
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Avatar_n_tn
have a question. I was taking oxycontin and oxycodone...I got off that **** cause I didn't like the stigma related to taking pain medications of that caliber... So, my doc put me on Ultram and all that did was make me dizzy, no warm fuzzy feeling...nothing. So, then my doc put me on Vicoden 10mg and still nothing no warm fuzzy feeling... What is going on? Can ultram make your receptors all messed up? I was off all narcotics a week before starting the ultram, which I did by tapering myself... Any hints...
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Avatar_n_tn
I have been in pain managment for several years and have been prescribed all the various opiate medications starting with 5mg of hydrocodone and now 20mg of oxycontin 4x daily as well as valium to be used as a muscle relaxor.

I now have the tolerance to pain meds of a bull and nothing seems to work ,however when I take the pain meds I often take motrin along with it .

One day I ran out of Motrin and took some Naproxin along with my regular meds as I had done so many times before.

Well not a half hour had passed and I started getting itchy arond my ankles and before I got home a 15 min drive my neck and scalp started itching as well.

By the time I got home it was so bad I ripped off my clothes and was covered with hives and welts from head to toe and most of my skin had turned beet red. I itched so bad I had to use a hair brush to scrath with and did that ( while on the phone with my pharmacist to find out what to do and if any contra indications with mmy meds  )until I started to bleed it was so bad.

The pharmacist said to take 2 benadryl right away and if it did not help go directly to the closet E-ROOM. I got lucky and in less than an hour I wds back to normal except for all the deep bleeding scatches .

That was very scary and unexpected as I had taken naproxn many times before and it tore my stomach up so stopped taking it and only took motrin mixed with my medications.

So I guess it just takes that one time to finally have an alergic (allergic) reation to any medication .

So I know how you felt and know it can happen to anyone .  
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Avatar_n_tn
i doubled my dosage of oxycoden as previously suggested, but that still doesnt help. I am 17 years old and 5'5 and 160 pounds and the perscription says take one or two of the 5mg pills every 6 hours also i take iy with 600 mg of ibuprofen. I still dont get sleep at night bc of the pain and i dont want to take more than the bottle says... so im just wondering i ate a big meal before so could that affect anything or i just got over a cold, i have no idea what would be the matter and am just askin for advise bc i cant get any other narcotics like above
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535089_tn?1400677119
Hi Timmy;
I have not heard it mentioned here that you really need to go back to your Surgeon or PCP and tell them what is going on with your pain.
Yes, there are other meds out there which are much stronger but you may not need a stronger med, just one that is right for you.
Jaybay had some great advise, While the oxycodone is stronger than Vicodin (Hydrocodone) in some respect, Vicodin might work better or you. It might adjust to your metabolism more effectivly.
There are also other NSAIDS available that work differently and better than IB. You might want to ask your Surgeon about Relafen (Nabumetone). It has a different compound than your ordinary Naprox or IB. and works very well for me and my inflammation. The other NSAIDS do not work for me.
Take care and good luck,
Mollyrae
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535089_tn?1400677119
You,ve posted on an old post. Please start a new thread....Ask a new question....You will get some good results. I answered your post but others might not. I did not look at the original date on the post.
I think it's too early in the morning for me yet LOL.
Anyway, start a new thread...(a new post)
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Avatar_n_tn
I am sitting in a bed right now due to acl reconstruction. I am on day3 it's 4 in the morning... and I just took two percocet and 1 toridol...or something like that. My mom is a nurse so I just do what she says.... I always find myself asking her..."I am not going to die am I" and she always says n o...and here I am today...so she is pretty trustworthy... the first day all I took was percocet and it didn't do anything. I stayed for 23 hour pbservation and was writhing in pain. They did that studpi 1-10 pain scale thing. and I found my self gritting my teeth and saying 7 a lot. When I got home, My mom finally gave me what she had for her knee surgery. (Toridol) and I took one with the percocet and pain was gone. I still haven;t gotten loopy yet, which is dissapoointing because my friends wanted a repeat of when I took the pills for my wisdom teeth being taken out. I was very loopy. But anyways, I just took my pills, because i woke up in soo much pain, I fell asleep and forgot my meds... so I am jsut waiting on them to work. My advice talk to your doc about the toridol and percocet combo.... it works for me...and I am not loop at all, but I do get a little tiny bit lighthead when I walk to the bathroom.
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535089_tn?1400677119
Fuzzykitten:

This is an old post and the poster is not around anymore. I would suggest starting a new thread........
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Avatar_n_tn
There is new information describing genetic pain receptor variations which may explain this phenomenon.  I have your exact same problem with the same medication regimen.  It may be related to variations in COMT or OPRM-1.  It seems silly that one opoid can be effective and another not.  In my hospital & oncology experience, I found that people like you and I will respond to dilaudid for some reason that cannot be explained.  Demerol (meperidine) which is only available as and injectable seems to do well in the younger population.  Without boring you with pharmacology, I would say that you are not the only person out there who reports this problem.. It is very easy for practitioners to start assuming drug seeking behaviors, so that is why you may get some resistance for asking for dilaudid when you need pain medication.  Remember Dilaudid is still in the same family of analgesics you are having a problem with.  So, you may find that this medication may not work either. It has a high addictive potential than medications that are combined with acetaminophen like Vicodin and Tylenol #3.
As for fentanyl, variants in the P-glycoprotein gene (ABCB1) conferring decreased transporter function have been associated with increased respiratory depressive effects of fentanyl. This is why people have difficulty with this medication.
Finally, there is also information that describes NSAIDs like ibuprofen, naproxen, etc. work best for men.  And that Kappa-opoid analgesics work best in women.  Hope all this info helps
-RxGirl
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547368_tn?1332173665
RX Girl,

This thread is well over two years old. I doubt the poster is still active. If you would like to share information with the community I suggest beginning a new thread. If you would like to contact the original poster I suggest you send them a PM. Some ppl will not even read an old thread.

Peace,
Tuck
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Avatar_n_tn
I am just wondering about this drug myself.  I have constant knee pain, and my doc gave me the cordisone shot in knee.  Did not help, gave me vicodin 500 mg... also to take aleve with this, did not help, now percocet and still in pain and my knee feels tight almost like it is swollen to bend the knee.  It hurts to drive as the pain is awful and there is nothing he can do.  Says I have arthritis in my knee.  So now what?  
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Avatar_m_tn
I have learned so much from this thread - I don't even care if the original poster is around anymore or not! I feel your pain - I was a moderator for an online support group for a long time. But sometimes, I think a thread stays around like this for a "higher purpose". Just let it go! :-)
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