Hi Dr,
It is great appreciated for your response. I was read about PSA test fPSA and cPSA. My friend had PSA test for past few years since age of 49, PSA range 1.3-1.4. This year, PSA jump to 9.6, then repeat after 5 week, PSA come back 3.8, at the same time did free PSA, but fPSA is very low, end up %fPSA/PSA about 11%, and this may need biopsy. But as I mentioned, PSA shows so much difference in such a short time. What is his means and if PSA and fPSA really correct or accurate? If those test results can be trusted to determine the biopsy? I read about tests, and all point to that cPSA is better than PSA, to calculate % to determine if biopsy is really needed. Specailly if PSA is under 4. %fPSA/PSA is not correct, only %fPSA/cPSA can tell. Is this right?
BUT the big issue here is in our state, no Lab provide cPSA test, only PSA and fPSA. Where I can obtain information that any Lab national wide can provide cPSA test and how local Dr's office can withdraw blood and send out for cPSA test?
Also, a lots other prostate infection or inflammation will lead to higher PSA value, which test or exam will be recommended to rule out other disease?
Your response and help are really appreciated.
Thank you in advance for your time and advice!
A variation in PSA can be due to several factors, the testing lab, contamination, degradation of the sample, whether or not you had a DRE (digital rectal examination) prior to a blood draw.
A repeat PSA, followed by a DRE should be done by your urologist. A biopsy may need to be performed as well.