HSV-1 Test

[cog1st]

I have had cold sores my entire life, I am now 45.  2 years ago I was hit with a severe nuerological case of Lyme Disease.  

I was tested for viruses..many came back positive. HHV6, EBV, HSV-1.  I have seen two doctors, they disagree that the IgG is past infection. One said it cannot be active unless the IgM is positive. Is this true?

I was put on Valtrex, EBV titers dropped (as of last test) but one of my doctor's is extremely focused on my HSV-1 test that is IgG positive (extremely high) and the IgM is also high.

I have wondered and cannot find, what are SYSTEMIC HSV-1 symptoms?  Valtrex is not lowering this titer oddly enough, while the other's are dropping.  

The doctor focused in on the HSV-1 keep saying I am shedding, I have no idea what that means, except that is is obviously active since the IgM is positive.  I think he believes many of my symptoms of pain, neuropathy are not from Lyme Disease but from a systemic herpes infection, made very active we believe by a cortisone shot.

1) IgG - does it mean active or past infection if positive?
2) What are the chances of this being a systemic infection with HSV-1 and what would the symptoms be?
3) With Valtrex not working on the HSV1, what would be the next medication to use?

Any other advice would be appreciated.


This discussion is related to Systemic symptoms with no sores - what is the likelihood of HSV2?.