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HSV2 Results
Male heterosexual that had unprotected sex four and a half months ago. At 8 weeks after unprotected sex developed rash all over inner thighs from training for a marathon at the beach, which I developed two small pimple looking spots on the base of my penis. This went away after 4 or 5 days. Went to the doctor and had a full std screen. Doctor thought the spots looked like a bacterial infection so she said to be sure get herpeselect test down hsv 2 IgG. This test came back at .08 after nine and a half weeks. Everything came back negative. Went back at 19 weeks to do the test again because I wanted to make sure even though she assured me everything was fine and it was a waste of money. Still I persisted and took the test for hsv 1 and hsv 2 using herpeselect. Hsv1 IgG came back at .91 and hsv 2 came back at 1.69. She said she has never seen this happen before and was not sure why the test changed. So I did research because I lost confidence in her and came to this website. Is this another case of a false positive or should I accept that the test is what it is. I went to a doctor and got the biokit assay test and he ordered it to the doctors office. From reading previous posts that seems what I should do.
1.) He ordered the lab to store my blood by freezing it or maybe refrigerating it until the biokit test came in on monday. I went to the doctors this thursday. Is that the proper method?
2.) How often are false positives?
3.) If the biokit test comes back negative after 20 weeks(roughly four and a half months) is that a definitive answer or do I need more testing.
1.) He ordered the lab to store my blood by freezing it or maybe refrigerating it until the biokit test came in on monday. I went to the doctors this thursday. Is that the proper method?
2.) How often are false positives?
3.) If the biokit test comes back negative after 20 weeks(roughly four and a half months) is that a definitive answer or do I need more testing.
MEDICAL PROFESSIONAL
Testingn stored blood if fine. It will not change the validity of the result. EWH
MEDICAL PROFESSIONAL
Before I address your question, let me congratulate you. You have a thorough doctor and you are approaching things in just the right fashion. there is an outside chance that you are seroconverting to HSV but I doubt it. I suspect your test result is false positive. You will know however next week following the Biokit. If it is positive, you have HSV-2, if not, you have a false positive result and can move on without any need for further testing. While there are a (very) small proportion of people who seroconvert later, given the unusual location of your lesions and your history to date, you can be sure using the results you'll get at this time. Please let us know what the Biokit shows. EWH
MEDICAL PROFESSIONAL
It was a false positve. you do not need a Biokit if you have a western blot result coming. You can see other discussions of false positves by searching on this topic on this site. It has been discussed many times. EWH
MEDICAL PROFESSIONAL
I predict that you do not have HSV-1 or HSV-2 and that this will be confirmed by your Western blot, the results of which will be either negative or equivocable which, when taken in the context of your other results, is the same as negative. EWH
I'm not sure you saw question number one on handling stored blood? I want to be sure it is properly done and I can move on if not I will go back when the test is there and give blood again. I gave a sample of my blood thursday which was stored is that the proper method for testing this monday. 4 days would have gone by. I think they said they are going to freeze it
MEDICAL PROFESSIONAL
There are many discussions of false positve and indeterminant Western blots on this site. I will provide a brief explanation of this VERY complex subject. For futher information you should search the site, get your doctor to more fully explain it or call the lab.
You have false positive tests because your antibodies cross react with one or several of the antigens which are tested for in assays like the HerpeSelect. These cross reacting antibodies are not directed at HSV but just "happen" to cross react with herpes antigens. They may be antibodies to a related virus like the herpes zoster (chicken pox) virus or something else. When you do an ELISA assay like the HerpeSelect it does not differentiate which antigens are being reacted with, just gives a numerical value.
A western blot resolves the test antigens more completely so that the lab can see exactly which of the many antigens in the test your antibodies react with. Your test is indeterminant on a Western blot because your antibodies detect some antigens in the test but not enough to say that you have antibodies to HSV. Given your history, as I have said, this means that you have a false positve test. EWH
You have false positive tests because your antibodies cross react with one or several of the antigens which are tested for in assays like the HerpeSelect. These cross reacting antibodies are not directed at HSV but just "happen" to cross react with herpes antigens. They may be antibodies to a related virus like the herpes zoster (chicken pox) virus or something else. When you do an ELISA assay like the HerpeSelect it does not differentiate which antigens are being reacted with, just gives a numerical value.
A western blot resolves the test antigens more completely so that the lab can see exactly which of the many antigens in the test your antibodies react with. Your test is indeterminant on a Western blot because your antibodies detect some antigens in the test but not enough to say that you have antibodies to HSV. Given your history, as I have said, this means that you have a false positve test. EWH
If you could just explain the indeterminate I would feel much better. I'm sorry this will be my last response.
I have spent a lot of money doing these test but what I don't have is an explanation of why they are indeterminate and what is going on. I am not stupid and I'm sure I could understand what is going on if you could entertain me. My doctor just called and she has all of my results and has said she has never seen anything like this before and she specializes in this field. I am at a loss. One month they are positive the next negative, and the icing on top at the end is indeterminate.
They did the testing for 1 and 2, why would they both be indeterminate? Or did the doctor not understand the results?
MEDICAL PROFESSIONAL
No it really is not realistically possible. If you look at the reply I gave you some time ago, this is just the response I predicted. The lab does not have the benifit of the additonal information I had. You do not have herpes. time for you to put this behind you and move on. EWH
my western blot results came back indeterminate. My doctor suggested taking the test in another month making it six and a half months. I'm confused, I guess the possibility of seroconverting is still possible after this long
can you tell me where you ordered your biokit from??
thank you
thank you
MEDICAL PROFESSIONAL
You are getting caught up in "what ifs" Straign to some of your questions:
first "what if" post
1. Five months is sufficient for over 95% of tests. No one really knows how long it will take for the remainig 5% and, in your case it is probably immaterial.
2. Zoloft will have no effect on your tests. Based on your questions, is it helping your anxiety?
2nd "what if" post
The test results bounce around based on a huge number of variables including humidity and temperature. Negative is negative.
You don't have herpes. Please accept that and stop your worrying. EWH
first "what if" post
1. Five months is sufficient for over 95% of tests. No one really knows how long it will take for the remainig 5% and, in your case it is probably immaterial.
2. Zoloft will have no effect on your tests. Based on your questions, is it helping your anxiety?
2nd "what if" post
The test results bounce around based on a huge number of variables including humidity and temperature. Negative is negative.
You don't have herpes. Please accept that and stop your worrying. EWH
1.) First time IgG Hsv 2 I received a (.10) at (two months after exposure)
2.) 2nd test at four months after for hsv 2 ( 1.69) and Hsv 1 (.91)
3.) 3rd test at five months Hsv 2 (.20) and Hsv 1 (.10)
* These test all used herpeselect IgG testing.
4.) Biokit and rapid hsv 1 and 2 testing Negative at five months and a week and a half.
5.) Waiting on western Blot results.
What would explain the 1.69 result and then go to .20 for hsv 2. I have researched your threads and I have not seen a 1.59 drop in hsv 2 igg antibodies. I have seen much less. When I got my blood drawn for the 1.69 herpeslect test I had to go back and do it again because they did not store my blood properly, should I call the lab and confirm those results in case of a mix up?
2.) 2nd test at four months after for hsv 2 ( 1.69) and Hsv 1 (.91)
3.) 3rd test at five months Hsv 2 (.20) and Hsv 1 (.10)
* These test all used herpeselect IgG testing.
4.) Biokit and rapid hsv 1 and 2 testing Negative at five months and a week and a half.
5.) Waiting on western Blot results.
What would explain the 1.69 result and then go to .20 for hsv 2. I have researched your threads and I have not seen a 1.59 drop in hsv 2 igg antibodies. I have seen much less. When I got my blood drawn for the 1.69 herpeslect test I had to go back and do it again because they did not store my blood properly, should I call the lab and confirm those results in case of a mix up?
I took the Biokit test yesterday and the test was negative. Also took another rapid blood igg test which was negative for hsv 1 and hsv 2. I am receiving the Western Blot Test results next week. I have a few questions?
1.) Is five months after exposure sufficient time in determining whether antibodies have developed or do I have a slight chance of seroconverting at a later date?
2.) Last week my doctor and we talked about the problem, he put me on Zoloft to help me with my anxiety over the past few days, would that alter or effect my blood results.(I sent off the western blot before I went on this medication)
3.) Have I done everything I can to truly find out my status?
1.) Is five months after exposure sufficient time in determining whether antibodies have developed or do I have a slight chance of seroconverting at a later date?
2.) Last week my doctor and we talked about the problem, he put me on Zoloft to help me with my anxiety over the past few days, would that alter or effect my blood results.(I sent off the western blot before I went on this medication)
3.) Have I done everything I can to truly find out my status?
What would explain the 1.69 hsv 2 result? How common is this as I am nearing the end of this problem that I am having. I also have the option to go from dc to nyc to get the biokit test done. I am willing to do this to provide further testing results. However, it is expensive, but money in my opinion is not a problem if it provides clarity on the issue. Is it worth going and doing it?
I sincerely want to thank you for all of your help. As a 25 year old male we tend to think life is over when finding out these results, I feel I have become a stronger person and put a lot of things in perspective while dealing with these test. I mean more of the big picture of life and how this is not the end of my of the world.
Much thanks
I sincerely want to thank you for all of your help. As a 25 year old male we tend to think life is over when finding out these results, I feel I have become a stronger person and put a lot of things in perspective while dealing with these test. I mean more of the big picture of life and how this is not the end of my of the world.
Much thanks
So I have an update. I could never get the biokit test done it became a logistical nightmare. However, I took the herpeselect test again and sent off blood work for the western blot. I just got my test results back again for the herpeselect test. This would have been my third time taking it. I am going back from the beginning to explain my latest results.
1.) First time IgG Hsv 2 I received a (.10) at (two months after exposure)
2.) 2nd test at four months after for hsv 2 ( 1.69) and Hsv 1 (.91)
3.) 3rd test at five months Hsv 2 (.20) and Hsv 1 (.10)
* These test all used herpeselect IgG testing.
What is your professional opinion of these results? Western blot will be back in two weeks.
1.) First time IgG Hsv 2 I received a (.10) at (two months after exposure)
2.) 2nd test at four months after for hsv 2 ( 1.69) and Hsv 1 (.91)
3.) 3rd test at five months Hsv 2 (.20) and Hsv 1 (.10)
* These test all used herpeselect IgG testing.
What is your professional opinion of these results? Western blot will be back in two weeks.
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Herpes spreads by oral, vaginal and anal sex.
Herpes sores blister, then burst, scab and heal.
STIs are the most common cause of genital sores.
Millions of people are diagnosed with STDs in the U.S. each year.
STDs can't be transmitted by casual contact, like hugging or touching.
Syphilis is an STD that is transmitted by oral, genital and anal sex.
