Aa
What are the implications?
Mitochondrial disease
IVF involving THREE PERSONS
Embryos that contain genetic material (DNA) from one man and two women were created recently by scientists at the University of Newcastle.
The research published in the journal Nature has the ability to help mothers suffering from rare genetic disorders to have healthy children.
The new method focuses on mitochondria, small particles within cells that act as batteries which provide energy to the cell. Mitochondria contain their own genetic material, which is separate from the nuclear genetic material containing sperm and egg.
The goal of scientists is to prevent the genetic material of damaged mitochondria to be transferred to the next generation of the mother.
About 200 children a year are born with mutations in mitochondrial DNA. In most cases it is only a mild illness, sometimes without any symptoms. However, about one in 6,500 children is born with mitochondrial disease, which can cause serious and possibly fatal disorders such as muscle weakness, blindness and heart failure.
Scientists have developed a technique that enables them to replace the defective mitochondria in the course of IVF.
The nuclei of the sperm of the father and the mother's egg (which contain the genetic material of the parents) are removed from the sperm and the egg, leaving the defective mitochondria.
Then the kernels are placed into an egg from the donor from which the nucleus has been removed, but kept them (the normal) mitochondria.
What emerges is an embryo that contains the genes of parents plus normal mitochondria and the genetic material from the egg of the donor.
It's like changing the battery in the computer but do not alter the hard disk. A baby born with this method is that mitochondria function normally come from donor eggs, but in all other respects is unchanged genetic material from the father and mother.
The mitochondrial genetic material from the donor to be transferred to the fetus is minimal, only 37 genes compared with at least 23.000 genes transferred to the fetus from each of their biological parents.
**********I found this doing research online. This is an IVF clinic in Greece called emBIO Medical Center. I think one day they will use this to recharge our "older eggs" battery cells. What do you all think? Pretty interesting -- right! I knew in theory this could be done.
IVF involving THREE PERSONS
Embryos that contain genetic material (DNA) from one man and two women were created recently by scientists at the University of Newcastle.
The research published in the journal Nature has the ability to help mothers suffering from rare genetic disorders to have healthy children.
The new method focuses on mitochondria, small particles within cells that act as batteries which provide energy to the cell. Mitochondria contain their own genetic material, which is separate from the nuclear genetic material containing sperm and egg.
The goal of scientists is to prevent the genetic material of damaged mitochondria to be transferred to the next generation of the mother.
About 200 children a year are born with mutations in mitochondrial DNA. In most cases it is only a mild illness, sometimes without any symptoms. However, about one in 6,500 children is born with mitochondrial disease, which can cause serious and possibly fatal disorders such as muscle weakness, blindness and heart failure.
Scientists have developed a technique that enables them to replace the defective mitochondria in the course of IVF.
The nuclei of the sperm of the father and the mother's egg (which contain the genetic material of the parents) are removed from the sperm and the egg, leaving the defective mitochondria.
Then the kernels are placed into an egg from the donor from which the nucleus has been removed, but kept them (the normal) mitochondria.
What emerges is an embryo that contains the genes of parents plus normal mitochondria and the genetic material from the egg of the donor.
It's like changing the battery in the computer but do not alter the hard disk. A baby born with this method is that mitochondria function normally come from donor eggs, but in all other respects is unchanged genetic material from the father and mother.
The mitochondrial genetic material from the donor to be transferred to the fetus is minimal, only 37 genes compared with at least 23.000 genes transferred to the fetus from each of their biological parents.
**********I found this doing research online. This is an IVF clinic in Greece called emBIO Medical Center. I think one day they will use this to recharge our "older eggs" battery cells. What do you all think? Pretty interesting -- right! I knew in theory this could be done.
Prague is beautiful! If I had the money and my ovaries could be stimulated (my FSH is very high) I'd go! Just make sure you check out the place thoroughly and their lab and stuff. But sounds like a great deal!
This article is fantastic news!
I've been doing some more research and clearly we are not that close... It is all theoretical still, but extremely interesting, right!? It looks like Israel may lead the way on this one, so let's keep an eye on this!
I don't see what "ethical" problems anyone should have with this, after all, it's not much different then DE procedure in that regard!
So I'm in my tww and going nuts, that's why I've been up to this research hehe, but I also came across ivf in Czech republic for 2500 including icis and assisted hatching! Have either one of you (or anyone) looked into this? It looks Luke they use the same standards as Europe and have really great outcomes. I am seriously considering taking a ivf vacation! The total cost will be around 5-6K and that includes three weeks vacation in or near Prague.. What do you guys think?
Even if it fails, they freeze any embies for a year and worst case scenario, you get a nice vacay!
I don't see what "ethical" problems anyone should have with this, after all, it's not much different then DE procedure in that regard!
So I'm in my tww and going nuts, that's why I've been up to this research hehe, but I also came across ivf in Czech republic for 2500 including icis and assisted hatching! Have either one of you (or anyone) looked into this? It looks Luke they use the same standards as Europe and have really great outcomes. I am seriously considering taking a ivf vacation! The total cost will be around 5-6K and that includes three weeks vacation in or near Prague.. What do you guys think?
Even if it fails, they freeze any embies for a year and worst case scenario, you get a nice vacay!
This is so amazing! A close friend of mine always tells me that it's just a matter of time before they can take the genetic material from the mother's egg and transplant it into a "healthy" egg of a donor. I think he's right; I just wish we could do it NOW.
Wow! Wow! Wow! That is utterly incredible! That sure would be nice wouldn't it? It'll probably end up costing us a fortune, because we still have to do all the same steps as IVF plus do that transplanting of the DNA to the donor egg, which will probably be another $5,000.00 or something like that. But hey, I bet in the end, it won't cost any more than actually using a donor egg like it's currently done. Thanks for posting! I'm going to have to go and check that out some more! That is just amazing!
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