Hashimotos or Graves?

[hopeful2006]

I posted a similar question but wondered--my TSI is high 799 when normal is <150.  But a few months back this test was conducted..a microsomal AB BLD which was 107.8 with normal being <5.  Are these the same tests with different names or are they different.  Do I understand correctly that TSI tests for Graves?  Would that be what I have?  By the way TSH is currently 0.010....my symptoms are hypo and hyper.  What is the microsomal?  My last endocrin who conducted that one told me I had Hashimotos  and that is was a matter of time before I went Hypo...so far since then my numbers are going more toward Hyper?  I am sooooo confused because my whole family is Hypo.

[hopeful2006]

Hi,
Not confusing at all--Actually very helpful.  I am very grateful for everyone's comments.  The past year has been crazy and quite confusing.  Finding a doctor to explain all this has been very difficult.  This is the most information that I have been able to gather and I have gone through 2 different endocrins and even tried to ask my PC doctor.  I have never been on any meds nor have I had the radioactive uptake.  I think my mom had Hashis--always low, but she made a comment that years back she had more Graves symptoms and wonders if she too had graves then hashi.  I wonder why take anything right now if in fact I am on my way to Hashis--well at least I have the Antibodies so probably on my way.  
Thanks again! I will keep posted--my appt with endocrin is in a few weeks.

[TXGrama]

It is possible to have both increased TSI and TPO antibodies.  These are two different tests.  TSI stands for thyroid stimulating immunoglobuins - are antibodies that attach to TSH receptors on thyroid follicular cells.  John Hopkins University has good explanation.  See the website below.

http://www.hopkinsmedicine.org/endocrine/graves/Answer.asp?QuestionID=22

TPO antibodies - thyroid peroxidase is an enzyme found in the thyroid gland & is important in production of thryoid hormone.  TPO antibodies attack this enzyme, which usually results in decreased function of thyroid hormones.  It is usually positive in Hashimotos, but can be present in Graves, too.

As is stated before TSI is associated with Graves, but I've had both since be diagnosed with Hashimotos.  It is not uncommon.  My doctor years ago felt at some point I probably had Graves.  Strictly Hashi for last 10 yrs+.

Your TSH appears low (which would mean hyperthyroidism or Graves), but you don't state if you've been medication such as Synthroid or Levoxyl, etc.  If you have been on medication, then the low TSH wouldn't be necessarily an indication of Graves - it could just be due to treatment for hypothyroidism or Hashi's.

Hope this isn't too confusing and helps you understand the tests a little better.

[Smilerdeb]

bumping this up for others to post ............

[Smilerdeb]

Its my understanding that microsomal AB BLD is Hashi's antibodies and TSI is Graves.
It looks like you may have both which isnt unheard of.

Microsomal AB BLD is known as: thyroid microsomal antibody

But let others post here too just to be sure.