Hi
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Generally a high ANA titre, high ESR indicates an autoimmune disease (SLE, Sjögren's syndrome, rheumatoid arthritis, autoimmune hepatitis, scleroderma, polymyositis, autoimmune hemolytic anemia, dermatomyositis). Depending on the pattern of ANA staining, other antibody tests will have to be done. If CPK is high, ask your doctor for a CPK isoenzyme test. CPK-1 or CPK-BB is elevated in brain or lung pathology. CPK-MB or CPK-2 in heart pathology and CPK-3 or CPK-MM is elevated if skeletal muscles are the cause.
I think you should discuss these possibilities with your doctor. It is difficult to comment beyond this without examining. A comprehensive investigation is required keeping all the points in mind. Take care!
Chiari Malformation or Fibromyalgia?
Some sort of autoimmune disease. Polymyositis would be a possibility also, particularly in view of the raised CK. If this has been draggin on for weeks or months, with good days and bad days thrown in, that strongly suggests an autoimmune process