elevated bilirubin,ALT and AST

[rani007]

I'm wiring this for my husband who is aged 28.He is a social drinker and no smoking habits.His last 3 months blood test shows elevated values for bilirubin,ALT and AST. All other test are normal.The last lab test values are following
Bilirubin Total- 1.6 mg/dl (Normal 0.3-1 mg/dl)
Bilirubin Direct- 0.3 mg/dl (Normal 0.1-0.31 mg/dl)
AST(SGOT)- 56 u/ml (Normal 5-55 u/ml)
ALT(SGPT)- 100 u/ml (Normal 5-35 u/ml)

Alkelie phosphate- 120u/l(Normal 100-250 u/l)
Albumin - 4.0 g/dl (Normal 3.5-5.5 g/dl)
Globulin - 2.8 g/dl (Normal 1.9-2.5 g/dl)
2 hr PP/RBS- 81 mg/dl (Normal <140mg/dl)
Ceruloplasmin- 38.0 mg/dl (Normal 15-60 mg/dl)
Ferritin- 106.6 ng/ml (Normal 22- 322 ng/ml)
Gamma GT - 33 (Normal 11-50M, 7-32 F IU/L)
creatinine - 0.84 mg/ dl ( Normal 0.6- 1.5 mg/ dl)
Prothrombin time - (a)Test- 13.9, (b)Control- 13.6,(c)INR-1.02 (Normal 11-14)
Haemoglobin- 16.0 gm/% (Normal 13-17)
ESR - 3 mm/hour (Normal 3-15)

HBsAg-ELISA = negative
HCV-ELISA = negative
ANA-ELISA= negative

Also his ultrasound scan report says mild splenomegaly with spleen size 13.1 cm.
Liver-  normal size Liver. small foci of calcium noted in the Right lobe anteriorly(old healed, no HBRD)
He also has a previous history of malaria, and typhoid in the year 2007.

we consulted a gasteroendrologist and he prescribed to take  URSOCOL 300mg for 1 month.He mentioned about biopsy after 1 month,if there is no change in values. Is there anything serious to him? is it due to fatty liver or anything else? nowadays He is worried very much? Please give us some midical advise? Thanks in advance

[Dr. Kokil Mathur]

Hi
Welcome to the MedHelp forum!
Actually all values including AST can be considered normal. ALT is at a higher end. Causes of liver transaminase (AST and ALT) elevations include viral hepatitis, alcohol use, medication use, steatosis or steatohepatitis, and cirrhosis. Steatosis and cirrhosis are ruled out by the ultrasound. Other common health conditions, such as diabetes, heart disease, pancreatitis, hemolytic anemia and thyroid disease, can also cause liver transaminase elevations. Most liver diseases are characterized by greater ALT elevations than AST elevations except cirrohsis and alcohol abuse. ALT also rises in bile duct obstruction due to stone. Since spleen is mildly enlarged please follow up with a hematologist to rule out hemolytic anemia.
Hope this helps. Take care!

[Peanuts2]

Has he been tested for Spirochetes?  (Lyme Disease)