I am a 37 year old female on Methadone Maintence for about 4 1/2 years. I have been having issues lately with my dose being stable. The doctor at my program suggested I have my thyroid tested for underactivity due to symptoms such as weight gain, eyebrow loss, sluggishness, numbness in my hands, swollen feet, legs and hands plus family history. There is also a family history of early menopause and my hormone levels show I am in that range. I have not been on birth control for 8 years and have never gotten pregnant so that was an issue also. My thyroid tested fine but my blood sugar level wasn't. My primary care Dr. started me on 500mg Metformin once daily for this and possibly PCOS. I've been on it for about 3 weeks now. My question is basically will any of this affect my methadone dose at all? I am having a lot of withdrawal symptoms before I get dosed. My stomach hurts, nose runs, jitteryness, and the hibby-jibbys, can't sit still, cold sweats. These go away when I take my dose of 90 mg methadose but throughout the day when I'm working I get horrible hot flashes with a runny nose and jitteryness and crawling skin that feels close to withdrawal symptoms. I'm trying to do research on all these issues and have follow up appointments with both doctors within the next month but it's driving me crazy and really getting up in my head. I will not relapse after 4 years being clean but the withdrawal symptoms are too much. I know it's not all in my head and I don't want to have to take the methadone so seriously. But I feel like I can't function normally until I get medicated. Thank you for your time and help. Katherine