I know that everyone is different, but I was just put on Limbrel 500mg. twice a day for osteoarthritis. I have taken Celebrex for years, and about 5 months ago, it really stopped doing much. I wondered if any of you take or have taken Limbrel. How long does it take for full effect and can you take Motrin or Tylenol with it. My doc says that I can take the Motrin in between the Celebrex wearing off and the Limbrel taking hold. I just hope that this is the answer to some of my pain. It is beginning to get in the way of my daily living and I am scared that if this gets worse, how will I function? I am 58 years old and have just started to babysit my first grandchild in Sept. As I write this, tears are welling up to think that I may have to give up watching her because of the pain. Please let me know any info on this med. Thanks, Linda