Thank you for reading. I could really use some insight and advice. My husband has seen a hematologist, immunologist, and gastroenterologist. I think we have more questions than answers. This started back in November 2016 when he went to the hospital for chest pain. It turned out to be his gallbladder and his heart was in good health. However, when the gastroenterologist ran a CBC a few times, he noticed that my husband has mild low platelets (now 96k).
The hematologist has been monitoring him since, but requires no treatment. All other blood work came back normal except for IgE which was high (116). We went to go see an immunologist and she re-ran anti-M2 antibody and ANA with reflex. The M2 antibody tested positive in November 2016, but has been negative in March and now July, 2017.
However, now he is ANA-Direct positive. Note: in November 2016 this was negative. The only specific ANA-related antibodies to test high was RNP (>8 when the normal range is 0.0-0.9). However, Matt has no symptoms of Mixed Connective Tissue Disorder or even ITP (thank God). No rash, no joint pain, no unusual fatigue, no petechiae, no bleeding.
The doctor that ordered the test is out of town. What do we do? Does he have to go see a rheumatologist? Could the ANA and RNP go back to negative like the M2 antibody did? Do these results really mean anything without symptoms?