single stranded DNA antibodies and IgG antibodies are predominately involved in the secondary antibody response, which occurs approximately one month following antigen recognition, thus the presence of specific IgG generally corresponds to maturation of the antibody response.
ssDNA is a single-strand DNA antibody (as opposed to the double-strand DNA antibody) and is yet another lupus test. It's one of the several that are used to confirm a lupus diagnosis. A negative test doesn't rule out lupus, but a positive result generally confirms it.
I'm not a doctor, but my guess is that with abnormal ssDNA and ANA tests, you're looking at a lupus diagnosis.
The patterns of the ANA mean something.
The speckled pattern can indicate SLE (lupus) and scleroderma.
The homogeneous pattern can indicate SLE (in high titers), rhematoid arthritis (in low titers)
I was dx with Fibromyalgia Syndrome in 1990. I was dx with IBS in the early 1980s. I have had 3 positive ana's for lupus. Each time, the doctors called it a false positive. I just got my blood work back once again, and this time the ana is positive for Nucleola pattern. The other 3 times it was speckled. I have a rash on my left hip for a year now. I have stomach pain coming and going. I havent had a decent bowel movement in a week. I do not know where else to turn. Please help me.
OK, the speckled pattern is most common and the least specific of the ANA patterns. It is seen in systemic lupuc, mixerd connective tissue disease, scleroderma, sjogren's syndrome. Further testing would include 1. anti-Smith 2. anti-RNP 3. Sci-70 kD kinetochore (anti-topoisomerase 1 4. anti-La (anti-SSB)
The nucleolar pattern is seen in scleroderma and cest syndrome. Further testing would be 1. Sci-70 2. PM-1
It is not uncommon for fibromalgia to occur along other major illnesses.
It doesn't sound like you have lupus. At least you have not listed the symptoms that goes along with that. Drs. not only look at the lab, they also look at symptoms.
I hope this helps you out.
what is a normal range for ssdna igg antibody test